Amg 517
- CAS No.
- 659730-32-2
- Chemical Name:
- Amg 517
- Synonyms
- CS-691;AM -517;Amg 517;AMG-517 ，S7115;AMG517; AMG-517;AMG 517, 10 mM in DMSO;N-[4-[[6-[4-(Trifluoromethyl)phenyl]-4-pyrimidinyl]oxy]-2-benzothiazolyl]acetamide;AcetaMide, N-[4-[[6-[4-(trifluoroMethyl)phenyl]-4-pyriMidinyl]oxy]-2-benzothiazolyl]-;N-(4-((6-(4-(Trifluoromethyl)phenyl)pyrimidin-4-yl)oxy)benzo[d]thiazol-2-yl)acetamide;N-[4-[[6-[4-(Trifluoromethyl)phenyl]-4-pyrimidinyl]oxy]-2-benzothiazolyl]acetamide AMG517
- CBNumber:
- CB82516228
- Molecular Formula:
- C20H13F3N4O2S
- Molecular Weight:
- 430.4
- MDL Number:
- MFCD14584859
- MOL File:
- 659730-32-2.mol
| Product description | Number | Pack Size | Price |
| AMG 517 | 26191 | 5mg | $68 |
| AMG 517 | 26191 | 10mg | $121 |
| AMG 517 | 26191 | 25mg | $268 |
| AMG 517 | 26191 | 50mg | $469 |
| AMG517 ≥98%(HPLC) | 5995 | 50 | $810 |
| More product size | |||
| Melting point | 227℃ |
|---|---|
| Density | 1.458 |
| storage temp. | Store at -20°C |
| solubility | ≥21.5 mg/mL in DMSO; insoluble in H2O; ≥4.93 mg/mL in EtOH |
| form | solid |
| pka | 10.19±0.70(Predicted) |
| color | White to off-white |
| FDA UNII | 172V4FBZ75 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
Amg 517 price More Price(30)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 26191 | AMG 517 | 659730-32-2 | 5mg | $68 | 2024-03-01 | Buy |
| Cayman Chemical | 26191 | AMG 517 | 659730-32-2 | 10mg | $121 | 2024-03-01 | Buy |
| Cayman Chemical | 26191 | AMG 517 | 659730-32-2 | 25mg | $268 | 2024-03-01 | Buy |
| Cayman Chemical | 26191 | AMG 517 | 659730-32-2 | 50mg | $469 | 2024-03-01 | Buy |
| Tocris | 5995 | AMG517 ≥98%(HPLC) | 659730-32-2 | 50 | $810 | 2021-12-16 | Buy |
Amg 517 Chemical Properties,Uses,Production
Uses
AMG-517 is a novel TRPV1 antagonist.
Biological Activity
AMG517 is an orally active, highly potent and selective vanilloid receptor-1 (TRPV1; VR1; capsaicin receptor) antagonist th at blocks TRPV1-mediated cellular Ca2+ influx (h/r/m IC50/stimulant = 0.76 nM/1.01 nM/1.9 nM/500 nM capsaicin; 0.62 nM/0.5 nM/0.63 nM/acid (pH 5) using respective CHO transfectants; IC50 >20 μM against TRPV2/3/4, TRPA1, and TRPM8-mediated responses; <45% binding at 10 μM to 87 receptors, enzymes, and ion channels) and exhibits antihyperalgesic efficacy in vivo (capsaicin-induced flinch = ED50 = 0.33 mg/kg rats, p.o.; CFA-induced thermal hyperalgesia, MED = 0.83 mg/kg rats, p.o.).
in vivo
AMG 517 is shown to be effective in a rodent "on-target" biochemical challenge model (capsaicin-induced flinch, ED50=0.33 mg/kg p.o.) and is antihyperalgesic in a model of inflammatory pain (CFA-induced thermal hyperalgesia, MED=0.83 mg/kg, p.o.)[1].The minimally effective dose is 0.3 mg/kg for AMG 517 and the corresponding plasma concentration is 90 ng/mL. Oral administration of AMG 517 reverses established thermal hyperalgesia in a dose-dependent manner at 21 h after CFA injection. AMG 517 causes transient hyperthermia in rodents, dogs, and monkeys. AMG 517 induces hyperthermia in a steep dose-dependent manner, with 0.3, 1, and 3 mg/kg associated with 0.5, 0.6, and 1.6°C increases in body temperature, respectively. Body temperatures of rats treated with all doses of AMG 517 return to baseline within 10 to 20 h[2].
storage
Store at +4°C
Amg 517 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 965 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49975 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5743 | 58 |
| Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd | +86-86-22-87899925 +86-8618522618860 | 18522618860@163.com | China | 694 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 12045 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32434 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30229 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39032 | 58 |
