PSN632408
- CAS No.
- 857652-30-3
- Chemical Name:
- PSN632408
- Synonyms
- 1-Piperidinecarboxylic acid, 4-[[3-(4-pyridinyl)-1,2,4-oxadiazol-5-yl]methoxy]-, 1,1-dimethylethyl ester;PSN632408;PSN632408,PSN-632408;PSN 632408; PSN-632408; PSN 632408; PSN-632408;tert-butyl 4-((3-(pyridin-4-yl)-1,2,4-oxadiazol-5-yl)methoxy)piperidine-1-carboxylate
- CBNumber:
- CB82592279
- Molecular Formula:
- C18H24N4O4
- Molecular Weight:
- 360.41
- MDL Number:
- MFCD09297322
- MOL File:
- 857652-30-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| PSN632408 ≥98% | 10008594 | 1mg | $31 |
| PSN632408 ≥98% | 10008594 | 5mg | $129 |
| PSN632408 ≥98% | 10008594 | 10mg | $228 |
| PSN632408 ≥98% | 10008594 | 25mg | $493 |
| PSN632408 ≥98% | 10008594 | 1mg | $28 |
| More product size | |||
| Boiling point | 513.8±60.0 °C(Predicted) |
|---|---|
| Density | 1.25±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| form | crystalline solid |
| pka | 0.79±0.10(Predicted) |
| color | White to off-white |
| FDA UNII | V4434XWK2P |
PSN632408 price More Price(42)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 10008594 | PSN632408 ≥98% | 857652-30-3 | 1mg | $31 | 2026-04-30 | Buy |
| Cayman Chemical | 10008594 | PSN632408 ≥98% | 857652-30-3 | 5mg | $129 | 2026-04-30 | Buy |
| Cayman Chemical | 10008594 | PSN632408 ≥98% | 857652-30-3 | 10mg | $228 | 2026-04-30 | Buy |
| Cayman Chemical | 10008594 | PSN632408 ≥98% | 857652-30-3 | 25mg | $493 | 2026-04-30 | Buy |
| Cayman Chemical | 10008594 | PSN632408 ≥98% | 857652-30-3 | 1mg | $28 | 2024-03-01 | Buy |
PSN632408 Chemical Properties,Uses,Production
Uses
PSN632408, a selective, orally active GPR119 agonist, shows similar potency to OEA at both recombinant mouse and human GPR119 receptors (EC50=5.6 and 7.9 uM, respectively). PSN632408 can stimulate β-cell replication and improve islet graft function. PSN632408 has the potential for the research of obesity and related metabolic disorders[1][2].
Biological Activity
psn632408 is a novel, selective and small-molecule agonist of human and mouse gpr119 with ec50 values of 5.6±0.99 μm and 7.9±0.7 μm, respectively [1].psn632408 has been reported to activate human and mouse gpr119 in a yeast fluorimetric assay with ec50 of 5.6±0.99 μm and 7.9±0.7 μm, respectively. in hek-osgpr116 cells, camp level was dose-dependently increased by psn632408 with an ec50 of 1.9±0.14 μm.. in vivo, psn632408 induced food intake reduction by using a rat feeding model and acute hypophagic effects in dose-dependence [1].
in vivo
PSN632408 (100 mg/kg; p.o.; daily for 14 days) suppresses food intake in rats and reduce body weight gain and white adipose tissue deposition upon subchronic oral administration to high-fat-fed rats[1].
| Animal Model: | Diet-induced obese (DIO) rats[1] |
| Dosage: | 100 mg/kg |
| Administration: | P.o.; daily for 14 days |
| Result: | The mean daily food intake was decreased by 10% during the first week of dosing and 15% during the second week. Body weight gain was significantly attenuated from day 6 onward with some evidence of weight loss. |
References
[1] overton ha1, babbs aj, doel sm, fyfe mc, gardner ls, griffin g, jackson hc, procter mj, rasamison cm, tang-christensen m, widdowson ps, williams gm, reynet c.deorphanization of a g protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents. cell metab. 2006 mar;3(3):167-75
PSN632408 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131956 | 58 |
| Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd. | 21-57721279 18121011378 | sales@shydchem.com.cn | China | 998 | 56 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7552 | 61 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4861 | 58 |
| EnliPharma Technology Co., Ltd | 0551-66399836 18955197623 | sales@enlipharma.com | China | 1876 | 55 |
| Suzhou yacoo science co.,Ltd | -- | lingling.qi@yacoo.com.cn | China | 6295 | 60 |
| SPIRO PHARMA | eric_feng1954@126.com | China | 9248 | 55 | |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9804 | 58 |
