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ChemicalBook >> CAS DataBase List >>1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-diMethylethyl) 2-Methyl ester, (2R,4S)-rel-

1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-diMethylethyl) 2-Methyl ester, (2R,4S)-rel-

1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-diMethylethyl) 2-Methyl ester, (2R,4S)-rel- Structure
1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-diMethylethyl) 2-Methyl ester, (2R,4S)-rel- structure
CAS No.
1145663-09-7
Chemical Name:
1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-diMethylethyl) 2-Methyl ester, (2R,4S)-rel-
Synonyms
rel-Boc-Hyp-OMe;N-Boc-trans-4-hydroxy-proline methyl ester;trans-1-Boc-4-hydroxypyrolidine-2-carboxylic acidmethyl ester;Trans-1-tert-butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate;1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-diMethylethyl) 2-Methyl ester, (2R,4S)-rel-
CBNumber:
CB82597724
Molecular Formula:
C11H19NO5
Molecular Weight:
245.27
MDL Number:
MFCD08752963
MOL File:
1145663-09-7.mol
MSDS File:
SDS
Last updated:2026-05-28 05:28:15
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1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-diMethylethyl) 2-Methyl ester, (2R,4S)-rel- Properties

Boiling point 335.2±42.0 °C(Predicted)
Density 1.216±0.06 g/cm3(Predicted)
pka 14.27±0.40(Predicted)
form Solid
color White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P280-P305+P351+P338

1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-diMethylethyl) 2-Methyl ester, (2R,4S)-rel- price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
aablocks AA00HCSZ trans-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1，2-dicarboxylate ≥97% 1145663-09-7 250mg $36 2026-05-28 Buy
aablocks AA00HCSZ trans-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1，2-dicarboxylate 98% 1145663-09-7 1g $46 2026-05-28 Buy
aablocks AA00HCSZ trans-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1，2-dicarboxylate 98% 1145663-09-7 5g $122 2026-05-28 Buy
aablocks AA00HCSZ trans-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1，2-dicarboxylate 98% 1145663-09-7 25g $424 2026-05-28 Buy
aablocks AA00HCSZ trans-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1，2-dicarboxylate 98% 1145663-09-7 100g $1653 2026-05-28 Buy
Product number Packaging Price Buy
AA00HCSZ 250mg $36 Buy
AA00HCSZ 1g $46 Buy
AA00HCSZ 5g $122 Buy
AA00HCSZ 25g $424 Buy
AA00HCSZ 100g $1653 Buy

1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-diMethylethyl) 2-Methyl ester, (2R,4S)-rel- Chemical Properties,Uses,Production

Uses

rel-Boc-Hyp-OMe is the isomer of Boc-Hyp-OMe (HY-65039), and can be used as an experimental control. Boc-Hyp-OMe is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-Hyp-OMe is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2].

References

[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. DOI:10.1038/nrd.2016.268
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. DOI:10.7554/eLife.57277

1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-diMethylethyl) 2-Methyl ester, (2R,4S)-rel- Preparation Products And Raw materials

Raw materials

Preparation Products

1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-diMethylethyl) 2-Methyl ester, (2R,4S)-rel- Suppliers

Global( 11)Suppliers
Supplier Tel Email Country ProdList Advantage
TaiChem Taizhou Limited 052386810091 zcwy9518@yeah.net China 3917 58
Nextpeptide Inc +86-0571-81612335 +8613336028439 sales@nextpeptide.com China 19904 58
Hebei Chishuo Biotechnology Co., Ltd. +86 311 66567340 aimee@speedgainpharma.com CHINA 9 58
Shanghai Xinxin Pharmaceutical Technology Co., Ltd. 13671725141 hickle@yeah.net China 768 58
Shanghai Haohong Pharmaceutical Co., Ltd. 400-8210725 4008210725 malulu@leyan.com China 54996 58
Shanghai Sunway Pharmaceutical Technology Co.,Ltd. 13611835272 13611835272 mmwang@sunwaypharm.com China 44090 58
Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd. 025-66061636 19370895928 qqyang@aikonchem.com China 9995 58
ANHUI BYERSEN BIOTECH CO. LTD +8617355064950 amy@byersenchemical.com China 10000 58
Zibo Hangyu Biotechnology Development Co., Ltd +86-0533-2185556 +86-15965530500 nickzhang@hangyubiotech.com China 9930 58
Supplier Advantage
TaiChem Taizhou Limited 58
Nextpeptide Inc 58
Hebei Chishuo Biotechnology Co., Ltd. 58
Shanghai Xinxin Pharmaceutical Technology Co., Ltd. 58
Shanghai Haohong Pharmaceutical Co., Ltd. 58
Shanghai Sunway Pharmaceutical Technology Co.,Ltd. 58
Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd. 58
ANHUI BYERSEN BIOTECH CO. LTD 58
Zibo Hangyu Biotechnology Development Co., Ltd 58

1145663-09-7(1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-diMethylethyl) 2-Methyl ester, (2R,4S)-rel-)Related Search:

trans-4-Amino-1-N-Boc-3-pyrrolidinecarboxylic acid ethyl ester (3R,4R)-1-tert-butyl 3,4-diethyl pyrrolidine-1,3,4-tricarboxylate Ethyl trans-1-Boc-4-hydroxypyrrolidine-3-carboxylate N-Boc-cis-4-Hydroxy-L-proline methyl ester (2R,4R)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate
Boc-Hyp-OH

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1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-diMethylethyl) 2-Methyl ester, (2R,4S)-rel- Trans-1-tert-butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate rel-Boc-Hyp-OMe N-Boc-trans-4-hydroxy-proline methyl ester trans-1-Boc-4-hydroxypyrolidine-2-carboxylic acidmethyl ester 1145663-09-7