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BrettPhos Pd G4

BrettPhos Pd G4 Structure
BrettPhos Pd G4 structure
CAS No.
1599466-83-7
Chemical Name:
BrettPhos Pd G4
Synonyms
BrettPhos Palladacycle Gen. 4;BrettPhos Pd G4;BrettPhos Pd G4c;Gingerol Impurity 5;BrettPhos Pd G4 ChemBeads;dicyclohexyl[3,6-dimethoxy-2,4,6-tris(propan-2-yl)-[1,1-;Methanesulfonato(2-dicyclohexylphosphino-3,6-dimethoxy-2',4',6'-tri-i-propyl-1,1'-biphenyl)(2;Methanesulfonato(2-dicyclohexylphosphino-3,6-dimethoxy-2',4',6'-tri-i-propyl-1,1'-biphenyl)(2'-methylamino-1,1'-biphenyl-2-yl)pa;Methanesulfonato(2-dicyclohexylphosphino-3,6-dimethoxy-2',4',6'-tri-i-propyl-1,1'-biphenyl)(2'-methylamino-1,1'-biphenyl-2-yl)palladium(II);(2-dicyclohexylphosphino-3,6-dimethoxy-2',4',6'-trisopropyl-1,1'-biphenyl)(2'-methylamino-1,1'-biphenyl-2-yl)methylsulfonylacidpaladium(I-I)
CBNumber:
CB83148149
Molecular Formula:
C49H68NO5PPds
Molecular Weight:
920.53
MDL Number:
MFCD29917502
MOL File:
1599466-83-7.mol
MSDS File:
SDS
Last updated:2026-05-28 05:14:02
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BrettPhos Pd G4 Properties

storage temp. 2-8°C, protect from light, stored under nitrogen
form Powder
color off-white to beige
InChIKey ZTBOMOZSCNBFNQ-UHFFFAOYSA-L
SMILES CC(C)C1=CC(C(C)C)=CC(C(C)C)=C1C2=C(P(C3CCCCC3)C4CCCCC4)C(OC)=CC=C2OC.CNC5=C(C6=C([Pd]OS(C)(=O)=O)C=CC=C6)C=CC=C5
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H319-H315
Precautionary statements  P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362
WGK Germany  WGK 3
HS Code  2843909000
Storage Class 11 - Combustible Solids

BrettPhos Pd G4 price More Price(34)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 804355 BrettPhos Pd G4 1599466-83-7 250MG $102 2026-04-30 Buy
Sigma-Aldrich 936952 BrettPhos Pd G4 ChemBeads 1599466-83-7 1 g $148 2026-04-30 Buy
Sigma-Aldrich 804355 BrettPhos Pd G4 1599466-83-7 1G $309 2026-04-30 Buy
Sigma-Aldrich 804355 BrettPhos Pd G4 1599466-83-7 5 g $1020 2026-04-30 Buy
Sigma-Aldrich 936952 BrettPhos Pd G4 ChemBeads 1599466-83-7 1 unit $132.05 2025-07-31 Buy
Product number Packaging Price Buy
804355 250MG $102 Buy
936952 1 g $148 Buy
804355 1G $309 Buy
804355 5 g $1020 Buy
936952 1 unit $132.05 Buy

BrettPhos Pd G4 Chemical Properties, Uses, Production

Reactions

Catalyst used for the N-arylation of amines. Reactions of 1599466-83-7

Uses

  • High Throughput Experimentation in Pharmaceutical Process Chemistry: This study evaluates the efficacy of BrettPhos Pd G4 in a ring closure reaction, emphasizing its selectivity and yield, which supports its potential utility in pharmaceutical synthesis (Solazzo, 2022).
  • Synthesis and characterization of fluorescent amino acid dimethylaminoacridonylalanine: Research detailing the use of various Buchwald precatalysts including BrettPhos Pd G4. The study explores the synthesis of a fluorescent amino acid, highlighting the specific conditions where BrettPhos Pd G4 provided notable benefits over other catalysts (Jones et al., 2021).

General Description

BrettPhos Pd G4 is an N-substituted 2-aminobiphenylpalladium methanesulfonate precatalyst. It is a fourth generation (G4) Buchwald precatalyst that is similar to the third generation (G3) precatalysts except that the amino group on the biphenyl backbone is methylated. This modification helps to prevent the limitations of using the third generation precatalysts. It is air, moisture and thermally-stable and shows good solubility in common organic solvents. BrettPhos Pd G4 is highly useful in cross-coupling reactions. Some of its excellent features include lower catalyst loadings, shorter reaction time, efficient formation of the active catalytic species and accurate control of ligand: palladium ratio.

reaction suitability

reaction type: Buchwald-Hartwig Cross Coupling Reaction
reaction type: Heck Reaction
reaction type: Hiyama Coupling
reaction type: Negishi Coupling
reaction type: Sonogashira Coupling
reaction type: Stille Coupling
reaction type: Suzuki-Miyaura Coupling
reagent type: catalyst
reaction type: Cross Couplings

BrettPhos Pd G4 synthesis

1070663-78-3
1581285-85-9
1599466-83-7
Synthesis of BrettPhos Pd G4 from 2-(Dicyclohexylphosphino)-3,6-dimethoxy-2'-4'-6'-tri-i-propyl-1,1'-biphenyl, min. 98% BrettPhos and (2'-Methylamino-1,1'-biphenyl-2-yl)methanesulfonatopalladium(II) dimer

BrettPhos Pd G4 Preparation Products And Raw materials

Raw materials

2-(Dicyclohexylphosphino)-3,6-dimethoxy-2'-4'-6'-tri-i-propyl-1,1'-biphenyl, min. 98% BrettPhos (2'-Methylamino-1,1'-biphenyl-2-yl)methanesulfonatopalladium(II) dimer

Preparation Products

BrettPhos Pd G4 Suppliers

Global Suppliers ( 125)
Supplier Tel Email Country ProdList Advantage
Wu Han Lbpchem Chemical Co., Ltd. 02763499399 13797220777 lpbchem@163.com China 99 58
xinxiang runyu material co.,Ltd 15690792173 sales@runvmat.com China 111 58
Wuhan phosphine biologic Pharmaceutical Co., LTD 15102702255 35729423@qq.com China 247 58
Zhengzhou Kingorgchem Chemical Technology Co., Ltd.gy Co., Ltd. 0371-65511006 18625597674 info@kingorgchem.com;sales@kingorgchem.com China 806 55
xinxiang runyu material co.,Ltd 03737759608 15690792173 sales@runvmat.com China 300 58
Beijing HwrkChemical Technology Co., Ltd 89508211 18501085097 sales.bj@hwrkchemical.com China 9407 55
Accela ChemBio Co.,Ltd. 021-50795510 4000665055 marketing@accelachem.com China 10972 64
Nanjin Cynthia chemicals Technology Co.,Ltd 0550-5618439 15951861180 cynthiachem@163.com China 291 62
WuHan Taiyukaishang Chemical Co., Ltd. 027-027-87680032 18963957250 taiyuchem@163.com China 180 55
T&W GROUP 021-61551611 13296011611 contact@trustwe.com China 9884 58
Supplier Advantage
Wu Han Lbpchem Chemical Co., Ltd. 58
xinxiang runyu material co.,Ltd 58
Wuhan phosphine biologic Pharmaceutical Co., LTD 58
Zhengzhou Kingorgchem Chemical Technology Co., Ltd.gy Co., Ltd. 55
xinxiang runyu material co.,Ltd 58
Beijing HwrkChemical Technology Co., Ltd 55
Accela ChemBio Co.,Ltd. 64
Nanjin Cynthia chemicals Technology Co.,Ltd 62
WuHan Taiyukaishang Chemical Co., Ltd. 55
T&W GROUP 58

View Latest Price from BrettPhos Pd G4 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Methanesulfonato(2-dicyclohexylphosphino-3,6-dimethoxy-2',4',6'-tri-i-propyl-1,1'-biphenyl)(2'-methylamino-1,1'-biphenyl-2-yl)palladium(II) pictures 2026-08-25 Methanesulfonato(2-dicyclohexylphosphino-3,6-dimethoxy-2',4',6'-tri-i-propyl-1,1'-biphenyl)(2'-methylamino-1,1'-biphenyl-2-yl)palladium(II)
1599466-83-7
 $2.00-5.00 1kg 99% 100kg ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
BrettPhos Pd G4 pictures 2025-12-23 BrettPhos Pd G4
1599466-83-7
 1G 98% 500 XINXIANG RUNYU MATERIAL CO., LTD.
Methanesulfonato(2-dicyclohexylphosphino-3,6-dimethoxy-2',4',6'-tri-i-propyl-1,1'-biphenyl)(2'-methylamino-1,1'-biphenyl-2-yl)palladium(II) / BrettPhos Pd G4 pictures 2021-06-11 Methanesulfonato(2-dicyclohexylphosphino-3,6-dimethoxy-2',4',6'-tri-i-propyl-1,1'-biphenyl)(2'-methylamino-1,1'-biphenyl-2-yl)palladium(II) / BrettPhos Pd G4
1599466-83-7
 $10.00 1g 0.98 50kg Wuhan LPBchem Technology Co.,Ltd

BrettPhos Pd G4 Spectrum

BrettPhos Pd G4(1599466-83-7)1HNMR

1599466-83-7 (BrettPhos Pd G4) Related Search:

Methanesulfonato(triphenylphosphine)(2'-amino-1,1'-biphenyl-2-yl)palladium(II) (PPH3 PD G3) BrettPhos Pd G3 RuPhos Pd G1 Methyl t--Butyl Ether Adduct BrettPhosPalladacycle Palladacycle Gen. 3
t-BuXphos Palladacycle Gen. 4 t-BuBrettPhos Palladacycle Gen. 3 SPhos Pd G3 SPhos Pd G1, Methyl t-Butyl Ether Adduct RuPhos Pd G2
tBuXPhos Pd G1 XPhos Pd G1 RuPhos Pd G3 Bis(diphenylphosphinophenyl)ether palladium (II) dichloride Bis(di-tert-butyl(4-dimethylaminophenyl)phosphine)dichloropalladium(II)
XPhos Pd G2 SPhos Pd G2 RuPhos Palladacycle Gen. 4

1of4

Methanesulfonato(2-dicyclohexylphosphino-3,6-dimethoxy-2',4',6'-tri-i-propyl-1,1'-biphenyl)(2'-methylamino-1,1'-biphenyl-2-yl)palladium(II) Methanesulfonato(2-dicyclohexylphosphino-3,6-dimethoxy-2',4',6'-tri-i-propyl-1,1'-biphenyl)(2'-methylamino-1,1'-biphenyl-2-yl)palladium(II), min METHANESULFONATO(2-DICYCLOHEXYLPHOSPHINO-3,6-DIMETHOXY-2',4',6'-TRI-I-PROPYL-1,1'-BIPHENYL)(2'-METHYLAMINO-1,1'-BIPHENYL-2-YL)PALLADIUM(II),MIN.98%[BRETTPHOSPALLADACYCLEGEN.4] Methanesulfonato(2-dicyclohexylphosphino-3,6-dimethoxy-2',4',6'-tri-i-propyl-1,1'-biphenyl)(2'-methylamino-1,1'-biphenyl-2-yl)palladium(II),[BrettPhos Palladacycle Gen. 4] Methanesulfonato(2-dicyclohexylphosphino-3,6-dimethoxy-2',4',6'-tri-i-propyl-1,1'-biphenyl)(2'-methylamino-1,1'-biphenyl-2-yl)palladium(II) / BrettPhos Pd G4 Methanesulfonato(2-dicyclohexylphosphino-3,6-dimethoxy-2',4',6'-tri-i-propyl-1,1'-biphenyl)(2 BrettPhos Pd G4 / Methanesulfonato(2-dicyclohexylphosphino-3,6-dimethoxy-2',4',6'-tri-i-propyl-1,1'-biphenyl)(2'-methylamino-1,1'-biphenyl-2-yl)palladium(II) dicyclohexyl[3,6-dimethoxy-2,4,6-tris(propan-2-yl)-[1,1- BrettPhos Pd G4c BrettPhos Pd G4 [2'-(Methylamino)-2-biphenylyl]palladium(1+) methanesulfonate-dicyclohexyl(2',4',6'-triisopropyl-3,6-dimethoxy-2-biphenylyl)phosphine (1:1:1) Methanesulfonato(2-dicyclohexylphosphino-3,6-dimethoxy-2',4',6'-tri-i-propyl-1,1'-biphenyl)(2'-methylamino-1,1'-biphenyl-2-yl)palladium(II) (BrettPhos Pd G4) Methanesulfonato(2-dicyclohexylphosphino-3,6-dimethoxy-2',4',6'-tri-i-propyl-1,1'-biphenyl)(2'-methylamino-1,1'-biphenyl-2-yl)pa Gingerol Impurity 5 BrettPhos Pd G4 ChemBeads Methanesulfonicacid(2-dicyclohexylphosphino-3,6-methoxy-2',4',6'-triisopropyl-1,1'-biphenyl)(2'-methylamino-1,1'-biphenyl-2-yl)palladium(II),BrettPhosPdG4 BrettPhos Palladacycle Gen. 4 Methanesulfonato(2-dicyclohexylphosphino-3,6-dimethoxy-2',4',6'-tri-i-propyl-1,1'-biphenyl)(2'-methylamino-1,1'-biphenyl-2-yl)palladium(II) (2-dicyclohexylphosphino-3,6-dimethoxy-2',4',6'-trisopropyl-1,1'-biphenyl)(2'-methylamino-1,1'-biphenyl-2-yl)methylsulfonylacidpaladium(I-I) BrettPhos Palladacycle Gen. 4 1599466-83-7 1594949-89-7 C49H68NO5PPdS Buchwald Ligands&Precatalysts Buchwald Precatalysts Series Pd