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3,4-Methylenedioxy-beta-nitrostyrene

3,4-Methylenedioxy-beta-nitrostyrene Structure
3,4-Methylenedioxy-beta-nitrostyrene structure
CAS No.
1485-00-3
Chemical Name:
3,4-Methylenedioxy-beta-nitrostyrene
Synonyms
(E)-5-(2-nitrovinyl)benzo[d][1,3]dioxole;5-(2-Nitrovinyl)-1,3-benzodioxole;MDBN;NSC 170724;MNS (MDBN);5-(2-Nitrovinyl);AKOS BBS-00006781;Syk Inhibitor III;MNS, 10 mM in DMSO;TIMTEC-BB SBB007833
CBNumber:
CB8314918
Molecular Formula:
C9H7NO4
Molecular Weight:
193.16
MDL Number:
MFCD00014575
MOL File:
1485-00-3.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-27 17:00:41
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3,4-Methylenedioxy-beta-nitrostyrene Properties

Melting point 159-163 °C
Boiling point 329.36°C (rough estimate)
Density 1.4058 (rough estimate)
refractive index 1.5200 (estimate)
storage temp. Sealed in dry,2-8°C
solubility Soluble in DMSO (up to 50 mg/ml).
form Yellow to brown solid
color Yellow
Sensitive Light Sensitive
BRN 192350
Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
InChI InChI=1S/C9H7NO4/c11-10(12)4-3-7-1-2-8-9(5-7)14-6-13-8/h1-5H,6H2
InChIKey KFLWBZPSJQPRDD-UHFFFAOYSA-N
SMILES O1C2=CC=C(C=C[N+]([O-])=O)C=C2OC1
CAS DataBase Reference 1485-00-3(CAS DataBase Reference)
EWG's Food Scores 1
NIST Chemistry Reference 3,4-Methylenedioxy-«beta»-nitrostyrene(1485-00-3)
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313
Hazard Codes  Xn,Xi,T
Risk Statements  36/37/38-22-25
Safety Statements  36/37/39-26-45
RIDADR  UN 2811 6.1/PG 3
WGK Germany  WGK 3
RTECS  WL5270000
HS Code  29329990
Storage Class 11 - Combustible Solids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
NFPA 704
1
2 0

3,4-Methylenedioxy-beta-nitrostyrene price More Price(48)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich S352918 3,4-METHYLENEDIOXY-BETA-NITROSTYRENE AldrichCPR 1485-00-3 1 unit $197 2026-04-30 Buy
Sigma-Aldrich 574713 Syk Inhibitor III 1485-00-3 50mg $161 2026-04-30 Buy
Sigma-Aldrich S352918 3,4-METHYLENEDIOXY-BETA-NITROSTYRENE Aldrich 1485-00-3 250mg $179 2024-03-01 Buy
TCI Chemical M3390 MNS min. 98.0 % 1485-00-3 100MG $55 2026-04-30 Buy
TCI Chemical M3390 MNS min. 98.0 % 1485-00-3 500MG $162 2026-04-30 Buy
Product number Packaging Price Buy
S352918 1 unit $197 Buy
574713 50mg $161 Buy
S352918 250mg $179 Buy
M3390 100MG $55 Buy
M3390 500MG $162 Buy

3,4-Methylenedioxy-beta-nitrostyrene Chemical Properties, Uses, Production

Description

MDBN (1485-00-3) is an irreversible inhibitor of p97 (IC50 < 10 μM). Cell permeable.

Chemical Properties

yellow powder

Uses

MDBN is a Src and Syk kinase inhibitor that prevents phosphorylation and cytoskeletal association of GPIIb/IIIa and talin.

Biological Activity

Selective inhibitor of Src and Syk tyrosine kinases. Displays antiaggregative activity via inhibition of GPIIb/IIIa activation (IC 50 = 12.7 μ M for thrombin-induced platelet aggregation). Exhibits no effects on Ca 2+ -dependent enzymes, PKC or arachidonic acid metabolism.

in vivo

MNS (20 mg/kg, i.p.) ameliorates experimental burn wound progression in Wistar rats by inhibiting the NLRP3 inflammasome activation[7].
MNS (30 mg/kg, p.o., 5 days) alleviates DSS-induced mouse colitis by inhibiting the NLRP3 inflammasome[8].
MNS (20mg/kg, i.p., 30min before reperfusion) significantly protects the kidneys from RIR injury in rats by reducing PANoptosis through specific inhibition of NLRP3[9].

IC 50

NLRP3 inflammasome

References

[1] TSUI-FEN CHOU R J D. Quantitative cell-based protein degradation assays to identify and classify drugs that target the ubiquitin-proteasome system.[J]. The Journal of Biological Chemistry, 2011, 286 19: 16546-16554. DOI:10.1074/jbc.m110.215319

3,4-Methylenedioxy-beta-nitrostyrene Preparation Products And Raw materials

Raw materials

Preparation Products

Homopiperonylamine 3,4-Methylenedioxyphenethylamine hydrochloride

3,4-Methylenedioxy-beta-nitrostyrene Suppliers

Global Suppliers ( 168)
Supplier Tel Email Country ProdList Advantage
Shandong Shining Pharm Co.,Ltd 18866891188 18866891188 zhaojiangxia@shiningpharm.com China 203 58
Shandong Xuanshuo Pharmaceutical Technology Co. LTD 15269103900 suchangzhou@shiningpharm.com China 383 58
Suzhou Chukai PharmaTech 0512-88812066 wenlongfcb@qq.com China 470 58
Shandong Fuchuang Pharmaceutical Technology Co. , Ltd. 0531-88792816 18663705731 fcpharm2006@126.com China 317 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
VDM Biochemicals 0330-2528181 sales@vdmbio.com United States 510 64
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Supplier Advantage
Shandong Shining Pharm Co.,Ltd 58
Shandong Xuanshuo Pharmaceutical Technology Co. LTD 58
Suzhou Chukai PharmaTech 58
Shandong Fuchuang Pharmaceutical Technology Co. , Ltd. 58
J & K SCIENTIFIC LTD. 76
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Alfa Aesar 84
Energy Chemical 61
VDM Biochemicals 64
Shanghai Hanhong Scientific Co.,Ltd. 64

View Latest Price from 3,4-Methylenedioxy-beta-nitrostyrene manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
MNS pictures 2026-07-27 MNS
1485-00-3
 $43.00 98.53% 10g TargetMol Chemicals Inc.
3,4-Methylenedioxy-beta-nitrostyrene pictures 2025-06-20 3,4-Methylenedioxy-beta-nitrostyrene
1485-00-3
 $50.00 1kg 0.99 10000 Hebei Yanxi Chemical Co., Ltd.
3,4-Methylenedioxy-beta-nitrostyrene pictures 2023-06-17 3,4-Methylenedioxy-beta-nitrostyrene
1485-00-3
 $150.00 1kg 99.9% 10000MT Henan Bao Enluo International TradeCo.，LTD
  • MNS pictures
  • MNS
    1485-00-3
  • $43.00
  • 98.53%
  • TargetMol Chemicals Inc.

3,4-Methylenedioxy-beta-nitrostyrene Spectrum

3,4-Methylenedioxy-beta-nitrostyrene(1485-00-3)MS3,4-Methylenedioxy-beta-nitrostyrene(1485-00-3)1HNMR3,4-Methylenedioxy-beta-nitrostyrene(1485-00-3)IR13,4-Methylenedioxy-beta-nitrostyrene(1485-00-3)IR2

1485-00-3 (3,4-Methylenedioxy-beta-nitrostyrene) Related Search:

4-Nitrostyrene trans-beta-Nitrostyrene Styrene 2,5-Dimethoxy-Beta-Nitrostyrene 1,2-Diphenylethylenediamine
(E)-2-Nitroethenylbenzene 4-Nitrobenzonitrile 1,4-Dioxane Selenium dioxide 4-Nitrobenzoyl chloride
5-(2-Nitroprop-1-enyl)-1,3-benzodioxole 3,4-Methylenedioxy-beta-nitrostyrene 1-(6-Bromo-3,4-methylenedioxyphenyl)-2-nitroethene 1-(3-Methoxy-4,5-methylenedioxyphenyl)-2-nitroethene 1-(3,4-(Methylenedioxy)-6-nitrophenyl)-2-nitroethene
1-(6-Bromo-3,4-methylenedioxyphenyl)-2-nitropropene beta-Nitroisomyristicin

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3,4-methylenedioxy-beta-nitro-styren 3,4-Methylenedioxy-omega-nitrostyrene 5-[(E)-2-Nitroethenyl]-1,3-benzodioxole 5-nitrovinyl-3-benzodioxole Benzene, 2-nitroethenyl, 3,4-methylenedioxy Ethene,-1-(3,4-methylendioxyphenyl)-2-nitro- Styrene, 3,4-methylenedioxy-beta-nitro- tyrene, 3,4-(methylenedioxy)-b-nitro- 5-[(E)-2-NITROVINYL]-1,3-BENZODIOXOLE AKOS BBS-00006781 3,4-METHYLENEDIOXYNITROSTYRENE 3,4-METHYLENEDIOXY-BETA-NITROSTYRENE 3,4-METHYLENEDIOXY-B-NITROSTYRENE 1-(3,4-METHYLENEDIOXYPHENYL) 2-NITROETHENE TIMTEC-BB SBB007833 4-Methylenedioxy-beta-nitrostyrene Syk Inhibitor III - CAS 1485-00-3 - Calbiochem 3,4-methylenedioxy-á-nitrostyrene 3,4-METHYLENDIOXY-BETA-NITROSTYRENE 3,4-METHYLENEDIOXY-SS-NITROSTYRENE 1-(2-Nitrovinyl)-3,4-methylenedioxybenzene 5-(2-Nitroethenyl)-1,3-benzodioxole -(2-Nitrovinyl)-1,3-benzodioxole -(2-Nitrovinyl)-3,4-methylenedioxybenzene ,4-(Methylenedioxy)-b-nitrostyrene ,4-Methylenedioxy-1-(2-nitrovinyl)benzene 1,3-Benzodioxole, 5-(2-nitroethenyl)- 1,3-Benzodioxole, 5-nitrovinyl- 5-(2-Nitrovinyl) Syk Inhibitor III 3,4-Methylenedioxy-beta-nitrostyrene,98% MNS (3,4-Methylenedioxy-β-nitrostyrene, MDBN) MNS (3,4-Methylenedioxy-&beta -nitrostyrene, MDBN) 5-(2-Nitrovinyl)benzo[d][1,3]dioxole MNS (3,4-Methylenedioxy-beta-nitrostyrene, MDBN) MDBN 5-(2-Nitrovinyl)benzodioxole NSC 170724 3,4-Methylenedioxy-β-nitrostyrene MNS (MDBN) MNS (NSC 170724, MDBN) thrombin,aggregation,NSC170724,Inhibitor,Src,MNS,NSC 170724,activation,inhibit,NSC-170724,Spleen tyrosine kinase,derivative,GPIIb/IIIa,beta-nitrostyrene,Syk,platelet MNS, 10 mM in DMSO MNS (3,4-Methylenedioxy-β-nitrostyrene) (E)-5-(2-nitrovinyl)benzo[d][1,3]dioxole 5-(2-Nitrovinyl)-1,3-benzodioxole 1485-00-3 Kinase/Phosphatase Biology Non-Receptor Tyrosine Kinase Inhibitors Spleen Tyrosine Kinase (Syk) Cell Biology Cell Signaling and Neuroscience BioChemical Ethanes/ethenes Inhibitors