4-Hydroxy-3,5-dimethoxycinnamic acid
- CAS No.
- 530-59-6
- Chemical Name:
- 4-Hydroxy-3,5-dimethoxycinnamic acid
- Synonyms
- SINAPIC ACID;SINAPINIC ACID;3,5-DIMETHOXY-4-HYDROXYCINNAMIC ACID;(E)-3-(4-hydroxy-3,5-diMethoxyphenyl)acrylic acid;trans-3,5-Dimethoxy-4-hydroxycinnamic acid;NSC 59261;Dimethoxy MS;Synapoic acid;Synapitic Acid;SIMPLEXOLIN(RG)
- CBNumber:
- CB8328696
- Molecular Formula:
- C11H12O5
- Molecular Weight:
- 224.21
- MDL Number:
- MFCD00004401
- MOL File:
- 530-59-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | ~202 °C |
|---|---|
| Boiling point | 285.61°C (rough estimate) |
| Density | 1.1478 (rough estimate) |
| refractive index | 1.4720 (estimate) |
| FLAVIS Number | 08.088 | 4-Hydroxy-3,5-dimethoxycinnamic acid (mixture of isomers) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | H2O: slightly soluble |
| form | powder |
| pka | 4.53±0.10(Predicted) |
| color | white |
| Odor | at 100.00%. odorless |
| Water Solubility | insoluble |
| BRN | 2130006 |
| Stability | Stable. Incompatible with strong oxidizing agents, strong bases. Combustible. |
| Cosmetics Ingredients Functions | SKIN CONDITIONING |
| InChI | 1S/C11H12O5/c1-15-8-5-7(3-4-10(12)13)6-9(16-2)11(8)14/h3-6,14H,1-2H3,(H,12,13)/b4-3+ |
| InChIKey | PCMORTLOPMLEFB-ONEGZZNKSA-N |
| SMILES | COc1cc(\C=C\C(O)=O)cc(OC)c1O |
| LogP | 0.997 (est) |
| CAS DataBase Reference | 530-59-6(CAS DataBase Reference) |
| FDA UNII | 68A28V6010 |
| NIST Chemistry Reference | Cinnamic acid, 4-hydroxy-3,5-dimethoxy-(530-59-6) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 29189900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
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| NFPA 704 |
|
4-Hydroxy-3,5-dimethoxycinnamic acid price More Price(94)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 85429 | Sinapic acid matrix substance for MALDI-MS, ≥99.0% (T) | 530-59-6 | 1g | $101 | 2026-04-30 | Buy |
| Sigma-Aldrich | 49508 | Sinapic acid matrix substance for MALDI-MS, ≥99.5%, Ultra pure | 530-59-6 | 10x10mg | $367 | 2026-04-30 | Buy |
| TCI Chemical | D1765 | 3,5-Dimethoxy-4-hydroxycinnamic Acid >98.0%(GC)(T) | 530-59-6 | 5g | $53 | 2026-04-30 | Buy |
| TCI Chemical | D1765 | 3,5-Dimethoxy-4-hydroxycinnamic Acid >98.0%(GC)(T) | 530-59-6 | 25g | $154 | 2026-04-30 | Buy |
| Cayman Chemical | 25457 | Sinapic Acid ≥98% | 530-59-6 | 1g | $36 | 2026-04-30 | Buy |
4-Hydroxy-3,5-dimethoxycinnamic acid Chemical Properties,Uses,Production
Chemical Properties
yellow-brown crystalline powder
Uses
4-Hydroxy-3,5-dimethoxycinnamic acid is a commonly used matrix in MALDI mass spectrometry. It is a useful matrix for a wide variety of peptides and proteins. It serves well as a matrix for MALDI due to its ability to absorb laser radiation and to also donate protons (H+) to the analyte of interest.
Uses
Sinapic acid was suitable as phenolic standard for HPLC analysis in determination of Sinapic acid derivatives in Canola extracts. 10 g/L of sinapinic acid with solvent was suitable as matrix for ultraviolet laser desorption mass spectrometric determination of proteins. It was also suitable to use as matrix for MALDI-TOFMS and MALDI-ion mobility-TOFMS to determine phospholipids in tissue.
Definition
ChEBI: A monohydroxycinnamic acid that is cinnamic acid in which the phenyl hydrogens at positions 3, 4, and 5 are replaced by methoxy, hydroxy, and methoxy groups, respectively.
General Description
Sinapic acid is an hydroxycinnamic acid derivative that occurs naturally in Brassicaceae species.
Biochem/physiol Actions
On removal of amino group from phenylalanine, catalysing with enzyme phenylalanine ammonia-lyase forms cinnamic acid. The precursor of hydroxycinnamates is produced after hydroxylation of benzene ring. One of the precursors produced is sinapic acid. Sinapic acid exhibits antimicrobial, antioxidant, anticancer, anti-inflammatory, and anti-anxiety activity. Sinapine (sinapoyl choline) has been acknowledged as an acetylcholinesterase inhibitor, making it therapeutically applicable in treatment of various diseases. 4-Vinylsyringol (a decarboxylation product of sinapic acid) is a potent antimutagenic and antioxidative agent, involved in suppressing the induction of inflammatory cytokines and carcinogenesis. Owing to their anti-oxidative activity, these compounds have been considered to be potentially employed in the pharmaceutical industry, cosmetics and food processing.
Purification Methods
Crystallise it from water. [Beilstein 10 H 508, 10 IV 2104.]
4-Hydroxy-3,5-dimethoxycinnamic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hangzhou J&H Chemical Co., Ltd. | 0571-87396432 | sales@jhechem.com | China | 14905 | 59 |
| Wuhan penglei Biotechnology Co., Ltd | 15871464247 17307245989 | 3471278124@qq.com | China | 4990 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
View Lastest Price from 4-Hydroxy-3,5-dimethoxycinnamic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-15 | Sinapicacid
530-59-6
|
1kg | 98% | 5000kg | Wuhan Fortuna Chemical Co.,Ltd | ||
 |
2026-06-30 | 4-Hydroxy-3,5-dimethoxycinnamic acid
530-59-6
|
1kg | 98% | 1000kg | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2023-02-24 | Sinapic acid
530-59-6
|
20mg | ≥98%(HPLC) | 10 g | Shanghai Standard Technology Co., Ltd. |
-
- Sinapicacid
530-59-6
- 98%
- Wuhan Fortuna Chemical Co.,Ltd
-
- 4-Hydroxy-3,5-dimethoxycinnamic acid
530-59-6
- $0.00
- 98%
- Shaanxi Dideu New Materials Co. Ltd
-
- Sinapic acid
530-59-6
- $0.00
- ≥98%(HPLC)
- Shanghai Standard Technology Co., Ltd.
