4-Amino-4'-chlorodiphenyl ether
- CAS No.
- 101-79-1
- Chemical Name:
- 4-Amino-4'-chlorodiphenyl ether
- Synonyms
- 4-(4-CHLOROPHENOXY)ANILINE;SALOR-INT L300845-1EA;Amoxapine Impurity 21;4-Chlorophenoxyaniline;p-(p-chlorophenoxy)-anilin;P-(P-CHLOROPHENOXY)ANILINE;4-(p-Chlorophenoxy)aniline;4-(4'-CHLOROPHENOXY)ANILINE;4-(4-Chlorophenoxy)benzamide;4-(4-CHLOROPHENOXY)BENZENAMINE
- CBNumber:
- CB8341082
- Molecular Formula:
- C12H10ClNO
- Molecular Weight:
- 219.67
- MDL Number:
- MFCD00043925
- MOL File:
- 101-79-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 99-103 °C |
|---|---|
| Boiling point | 205 °C / 12mmHg |
| Density | 1.1764 (rough estimate) |
| refractive index | 1.6000 (estimate) |
| storage temp. | 2-8°C |
| solubility | DMSO (Slightly), Methanol (Slightly, Heated) |
| form | powder to crystal |
| pka | 4.60±0.10(Predicted) |
| color | White to Light yellow to Light orange |
| Water Solubility | Insoluble in water. |
| InChI | 1S/C12H10ClNO/c13-9-1-5-11(6-2-9)15-12-7-3-10(14)4-8-12/h1-8H,14H2 |
| InChIKey | YTISFYMPVILQRL-UHFFFAOYSA-N |
| SMILES | Nc1ccc(Oc2ccc(Cl)cc2)cc1 |
| CAS DataBase Reference | 101-79-1(CAS DataBase Reference) |
| EPA Substance Registry System | Benzenamine, 4-(4-chlorophenoxy)- (101-79-1) |
| UNSPSC Code | 12352100 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H315-H317-H318-H335 | |||||||||
| Precautionary statements | P280-P301+P312+P330-P302+P352-P305+P351+P338+P310 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Faceshields, Gloves | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-40-43-41-37/38-22 | |||||||||
| Safety Statements | 26-36/37/39-36/37 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | BX1770000 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29222990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Dam. 1 Skin Irrit. 2 Skin Sens. 1 STOT SE 3 |
|||||||||
| NFPA 704 |
|
4-Amino-4'-chlorodiphenyl ether price More Price(47)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 695386 | 4-(4-Chlorophenoxy)aniline 97% | 101-79-1 | 5g | $88.7 | 2023-06-20 | Buy |
| Sigma-Aldrich | 695386 | 4-(4-Chlorophenoxy)aniline 97% | 101-79-1 | 25g | $215 | 2023-01-07 | Buy |
| TCI Chemical | C1069 | 4-Amino-4'-chlorodiphenyl Ether min. 98.0 % | 101-79-1 | 5G | $45 | 2026-04-30 | Buy |
| TCI Chemical | C1069 | 4-Amino-4'-chlorodiphenyl Ether >98.0%(GC)(T) | 101-79-1 | 25g | $154 | 2026-04-30 | Buy |
| Activate Scientific | AS92872 | 4-(4-Chlorophenoxy)aniline 97% | 101-79-1 | 5g | $27 | 2026-06-04 | Buy |
4-Amino-4'-chlorodiphenyl ether Chemical Properties, Uses, Production
Chemical Properties
Dark powder
Uses
It is used as an active pharmaceutical intermediate.
Synthesis
1836-74-4
101-79-1
General procedure for the synthesis of 4'-chloro-4-amino-diphenyl ether from 4'-chloro-4-nitro-diphenyl ether: general method: 1-substituted-4-nitrobenzene (9.3 mmol) and hydrazine hydrate (27.9 mmol) were dissolved in 20 mL of ethanol, and stirred for 10 min at 28-30°C. The reaction was carried out in aqueous suspension of Raney-Ni (0.02 g). An aqueous suspension of Raney-Ni (0.02 g, 4.41 mL) was added in three 10-min intervals. after 30 min, the reaction was allowed to plateau, and the temperature was raised to 50-60 °C to continue stirring for 6 h. The catalyst was removed by filtration. After completion of the reaction, the catalyst was removed by filtration. The solvent was removed by evaporation to give the target product 4'-chloro-4-amino-diphenyl ether.
References
[1] Green Chemistry, 2017, vol. 19, # 14, p. 3400 - 3407
[2] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 7, p. 1588 - 1592
[3] Journal of Medicinal Chemistry, 2013, vol. 56, # 11, p. 4811 - 4815
[4] Pharmazie, 1980, vol. 35, # 2, p. 78 - 80
4-Amino-4'-chlorodiphenyl ether Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
View Latest Price from 4-Amino-4'-chlorodiphenyl ether manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | 4-Amino-4'-chlorodiphenyl ether
101-79-1
|
$1.00 | 1KG | 98% | 1kg,5kg,100kg | Career Henan Chemical Co |
-
- 4-Amino-4'-chlorodiphenyl ether
101-79-1
- $1.00
- 98%
- Career Henan Chemical Co
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