2-(4-CHLOROPHENOXY)ANILINE
- CAS No.
- 2770-11-8
- Chemical Name:
- 2-(4-CHLOROPHENOXY)ANILINE
- Synonyms
- 2-Amino-4'-chlorodiphenyl Ether;Amoxapine RC 4;Amoxapine Impurity 2;2-(4-CHLOROPHENOXY)ANILINE;2-(4'-CHLOROPHENOXY)ANILINE;2-(4-chlorophenoxy)benzenamine;[2-(4-chlorophenoxy)phenyl]amine;Benzenamine, 2-(4-chlorophenoxy)-;2-Amino-4'-chlorodiphenyl Ether >2-Amino-4'-chlorodiphenyl Ether, ≥ 98.0%
- CBNumber:
- CB3739965
- Molecular Formula:
- C12H10ClNO
- Molecular Weight:
- 219.67
- MDL Number:
- MFCD00025168
- MOL File:
- 2770-11-8.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 2-Amino-4'-chlorodiphenyl Ether >98.0%(GC)(T) | A2223 | 5g | $148 |
| 2-(4-Chlorophenoxy)aniline 98% | AS48966 | 1g | $18 |
| 2-(4-Chlorophenoxy)aniline 98% | OR315743 | 1g | $21 |
| 2-(4-Chlorophenoxy)aniline 98% | OR315743 | 5g | $37 |
| 2-(4-Chlorophenoxy)aniline 98% | AS48966 | 5g | $48 |
| More product size | |||
| Boiling point | 202°C/15mmHg(lit.) |
|---|---|
| Density | 1.260±0.06 g/cm3(Predicted) |
| refractive index | 1.6180-1.6220 |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | Chloroform (Sparingly), Methanol (Slightly) |
| form | Oil |
| pka | 3.69±0.10(Predicted) |
| color | Colourless to Light Orange |
| CAS DataBase Reference | 2770-11-8(CAS DataBase Reference) |
| FDA UNII | EGP2SG2VOE |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2922290090 | |||||||||
| NFPA 704 |
|
2-(4-CHLOROPHENOXY)ANILINE price More Price(46)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | A2223 | 2-Amino-4'-chlorodiphenyl Ether >98.0%(GC)(T) | 2770-11-8 | 5g | $148 | 2026-04-30 | Buy |
| Activate Scientific | AS48966 | 2-(4-Chlorophenoxy)aniline 98% | 1g | $18 | 2026-06-04 | Buy | |
| Apolloscientific | OR315743 | 2-(4-Chlorophenoxy)aniline 98% | 2770-11-8 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR315743 | 2-(4-Chlorophenoxy)aniline 98% | 2770-11-8 | 5g | $37 | 2026-06-04 | Buy |
| Activate Scientific | AS48966 | 2-(4-Chlorophenoxy)aniline 98% | 5g | $48 | 2026-06-04 | Buy |
2-(4-CHLOROPHENOXY)ANILINE Chemical Properties,Uses,Production
Chemical Properties
pale yellow powder
Uses
Amoxapine impurity.
Synthesis
![1-[(4-Chlorophenyl)oxy]-2-nitrobenzene](/CAS/GIF/39145-47-6.gif)
39145-47-6
2770-11-8
General procedure for the synthesis of 4'-chloro-2-amino-diphenyl ether from 1-(4-chlorophenoxy)-2-nitrobenzene: A mixture of commercially available iron powder (3.18 g, 57.28 mmol) and ammonium chloride (383 mg, 7.15 mmol) in ethanol (45 mL) and water (8 mL) was refluxed. To this mixture was added 1-(4-chlorophenoxy)-2-nitrobenzene (AMR01028,2.2 g, 8.81 mmol) and the resulting mixture was stirred at reflux for 1 hour. After completion of the reaction, the solvent was removed and the residue was diluted in aqueous sodium bicarbonate (40 mL) and extracted with dichloromethane (3 x 20 mL). The organic layers were combined, dried with anhydrous magnesium sulfate, filtered and the solvent was evaporated to give 4'-chloro-2-amino-diphenyl ether (AMR01029,1.50 g, 78%) as a colorless oil, which could be used in the next step without further purification. Thin layer chromatography (TLC) Rf value was 0.53 (unfolding agent: dichloromethane).1H NMR (270MHz, CDCl3) data: δ 3.77 (2H, broad single peak, NH2), 6.71 (1H, multiple peaks), 6.83 (2H, multiple peaks), 6.89 (2H, AA'BB' system), 6.99 (1H, multiple peaks), 7.25 ( 2H, AA'BB' system).
References
[1] Patent: WO2007/3934, 2007, A2. Location in patent: Page/Page column 119
[2] Journal of the American Chemical Society, 2014, vol. 136, # 40, p. 14060 - 14067
[3] Journal of the Chemical Society, 1931, p. 529,533
[4] Journal of the Chemical Society, 1925, vol. 127, p. 2011
[5] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1976, p. 1279 - 1285
2-(4-CHLOROPHENOXY)ANILINE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30224 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18126 | 58 |
| ZHEJIANG JIUZHOU CHEM CO., LTD | +86-0576225566889 +86-13454675544 | admin@jiuzhou-chem.com；jamie@jiuzhou-chem.com；alice@jiuzhou-chem.com | China | 12272 | 58 |
| Lewoo Pharmatech(Shanghai)Co.,Ltd | +86-15800805830 | miao@lewoopharma.com.cn | China | 184 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 43333 | 58 |
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