2-(4-Chlorophenoxy)aniline
- CAS No.
- 2770-11-8
- Chemical Name:
- 2-(4-Chlorophenoxy)aniline
- Synonyms
- 2-Amino-4'-chlorodiphenyl Ether;Amoxapine RC 4;Amoxapine Impurity 2;2-(4-Chlorophenoxy)aniline;2-(4'-CHLOROPHENOXY)ANILINE;2-(4-chlorophenoxy)benzenamine;[2-(4-chlorophenoxy)phenyl]amine;Benzenamine, 2-(4-chlorophenoxy)-;2-Amino-4'-chlorodiphenyl Ether >2-Amino-4'-chlorodiphenyl Ether, ≥ 98.0%
- CBNumber:
- CB3739965
- Molecular Formula:
- C12H10ClNO
- Molecular Weight:
- 219.67
- MDL Number:
- MFCD00025168
- MOL File:
- 2770-11-8.mol
- MSDS File:
- SDS
| Boiling point | 202°C/15mmHg(lit.) |
|---|---|
| Density | 1.260±0.06 g/cm3(Predicted) |
| refractive index | 1.6180-1.6220 |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | Chloroform (Sparingly), Methanol (Slightly) |
| form | Oil |
| pka | 3.69±0.10(Predicted) |
| color | Colourless to Light Orange |
| CAS DataBase Reference | 2770-11-8(CAS DataBase Reference) |
| FDA UNII | EGP2SG2VOE |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2922290090 | |||||||||
| NFPA 704 |
|
2-(4-Chlorophenoxy)aniline price More Price(39)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | A2223 | 2-Amino-4'-chlorodiphenyl Ether >98.0%(GC)(T) | 2770-11-8 | 5g | $148 | 2026-04-30 | Buy |
| Activate Scientific | AS48966 | 2-(4-Chlorophenoxy)aniline 98% | 1g | $18 | 2026-06-04 | Buy | |
| Apolloscientific | OR315743 | 2-(4-Chlorophenoxy)aniline 98% | 2770-11-8 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR315743 | 2-(4-Chlorophenoxy)aniline 98% | 2770-11-8 | 5g | $37 | 2026-06-04 | Buy |
| Activate Scientific | AS48966 | 2-(4-Chlorophenoxy)aniline 98% | 5g | $48 | 2026-06-04 | Buy |
2-(4-Chlorophenoxy)aniline Chemical Properties, Uses, Production
Chemical Properties
pale yellow powder
Uses
Amoxapine impurity.
Synthesis
![1-[(4-Chlorophenyl)oxy]-2-nitrobenzene](/CAS/GIF/39145-47-6.gif)
39145-47-6
2770-11-8
General procedure for the synthesis of 4'-chloro-2-amino-diphenyl ether from 1-(4-chlorophenoxy)-2-nitrobenzene: A mixture of commercially available iron powder (3.18 g, 57.28 mmol) and ammonium chloride (383 mg, 7.15 mmol) in ethanol (45 mL) and water (8 mL) was refluxed. To this mixture was added 1-(4-chlorophenoxy)-2-nitrobenzene (AMR01028,2.2 g, 8.81 mmol) and the resulting mixture was stirred at reflux for 1 hour. After completion of the reaction, the solvent was removed and the residue was diluted in aqueous sodium bicarbonate (40 mL) and extracted with dichloromethane (3 x 20 mL). The organic layers were combined, dried with anhydrous magnesium sulfate, filtered and the solvent was evaporated to give 4'-chloro-2-amino-diphenyl ether (AMR01029,1.50 g, 78%) as a colorless oil, which could be used in the next step without further purification. Thin layer chromatography (TLC) Rf value was 0.53 (unfolding agent: dichloromethane).1H NMR (270MHz, CDCl3) data: δ 3.77 (2H, broad single peak, NH2), 6.71 (1H, multiple peaks), 6.83 (2H, multiple peaks), 6.89 (2H, AA'BB' system), 6.99 (1H, multiple peaks), 7.25 ( 2H, AA'BB' system).
References
[1] Patent: WO2007/3934, 2007, A2. Location in patent: Page/Page column 119
[2] Journal of the American Chemical Society, 2014, vol. 136, # 40, p. 14060 - 14067
[3] Journal of the Chemical Society, 1931, p. 529,533
[4] Journal of the Chemical Society, 1925, vol. 127, p. 2011
[5] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1976, p. 1279 - 1285
2-(4-Chlorophenoxy)aniline Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15350 | 60 |
| Chengdu Forest Science and Technology Development Co., Ltd. | 18030648795 18030648795 | sales@cdforestchem.com | China | 1998 | 58 |
| Wuhan TCASChem Technology Co., Ltd. | 027-86697669 13986148687 | sales@tcaschem.com | China | 4000 | 55 |
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28364 | 80 |
| TCI Europe | 320-37350700 | sales@tcieurope.eu | Europe | 23654 | 75 |
| TCI AMERICA | 800-4238616 | sales@tciamerica.com | Americas | 23636 | 75 |
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