2,3-Difluorophenylboronic acid
- CAS No.
- 121219-16-7
- Chemical Name:
- 2,3-Difluorophenylboronic acid
- Synonyms
- 2,3-Difl;RARECHEM AH PB 0166;2,3-Difluorophenylbo;Difluorophenylboronic aci;2,3-difluorobenzorbic acid;2,3-DIFLUOROPHENYLBORONIC ACID;2,3-FLUOROBENZENE BORONIC ACID;2,3-Dilfuorophenylboronic acid;2,3-DIFLUOROBENZENEBORONIC ACID;2,3-Difluorobenzeneboronicacid98%
- CBNumber:
- CB8351070
- Molecular Formula:
- C6H5BF2O2
- Molecular Weight:
- 157.91
- MDL Number:
- MFCD01863170
- MOL File:
- 121219-16-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 95 °C (dec.) (lit.) |
|---|---|
| Boiling point | 274.8±50.0 °C(Predicted) |
| Density | 1.35±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | soluble in Methanol |
| pka | 7.29±0.58(Predicted) |
| form | Crystalline Powder |
| color | White to light beige |
| BRN | 6594341 |
| InChI | InChI=1S/C6H5BF2O2/c8-5-3-1-2-4(6(5)9)7(10)11/h1-3,10-11H |
| InChIKey | SZYXKFKWFYUOGZ-UHFFFAOYSA-N |
| SMILES | B(C1=CC=CC(F)=C1F)(O)O |
| CAS DataBase Reference | 121219-16-7(CAS DataBase Reference) |
| UNSPSC Code | 12352103 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H335-H315-H319 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 | |||||||||
| PPE | Eyeshields, Gloves, type N95 (US) | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 36/37/38-22 | |||||||||
| Safety Statements | 37/39-26-36/37 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29163990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral | |||||||||
| NFPA 704 |
|
2,3-Difluorophenylboronic acid price More Price(88)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 514039 | 2,3-Difluorophenylboronic acid | 121219-16-7 | 5g | $42.2 | 2023-06-20 | Buy |
| Sigma-Aldrich | 514039 | 2,3-Difluorophenylboronic acid | 121219-16-7 | 25g | $183 | 2023-06-20 | Buy |
| TCI Chemical | D3523 | 2,3-Difluorophenylboronic Acid (contains varying amounts of Anhydride) | 121219-16-7 | 5g | $45 | 2026-04-30 | Buy |
| TCI Chemical | D3523 | 2,3-Difluorophenylboronic Acid (contains varying amounts of Anhydride) | 121219-16-7 | 25g | $135 | 2026-04-30 | Buy |
| Usbiological | 273477 | 2,3-Difluorophenylboronic acid Asreported | 121219-16-7 | 10g | $365 | 2026-06-03 | Buy |
2,3-Difluorophenylboronic acid Chemical Properties, Uses, Production
Chemical Properties
Off-white to light beige crystalline powder
Uses
suzuki reaction
Uses
2,3-Difluorophenylboronic acid is a useful reagent for the preparation of pharmaceutical and biologically active molecules.
Uses
Intermediates of Liquid Crystals
Synthesis
688-71-1
367-11-3
121219-16-7
The general procedure for the synthesis of 2,3-difluorophenylboronic acid from tri-n-propyl borate and 1,2-difluorobenzene is as follows: in a 1L three-necked flask equipped with a mechanical stirrer, nitrogen inlet and outlet, pressure-balancing dropping funnel, and a thermometer, 1,2-difluorobenzene (40 g, 0.35 mol) and anhydrous tetrahydrofuran (400 ml) were added. Nitrogen was introduced to displace the air in the reaction system and a weak flow of nitrogen was maintained throughout the reaction. The reaction mixture was cooled to -78 °C using a dry ice/acetone bath, followed by the slow dropwise addition of 2.5 mol/L hexane solution of n-butyllithium (140 ml, 0.35 mol) through a dropping funnel, controlling the reaction temperature to not exceed -70 °C. After the dropwise addition of n-butyllithium solution was completed, the reaction mixture was continued to be stirred at -78 °C for 2 hours. Subsequently, tri-n-propyl borate (66 g, 0.35 mol) was added dropwise, again keeping the reaction temperature below -70 °C. After the addition of tri-n-propyl borate, the cooling bath was withdrawn and the reaction mixture was allowed to warm up naturally to room temperature with continuous stirring. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure to give a viscous liquid residue. The residue was acidified and the resulting propanol was subsequently evaporated. The precipitated solid product was collected by filtration, washed with hexane and purified by aqueous recrystallization to give a final white crystalline 2,3-difluorophenylboronic acid 47 g in 85% of theoretical yield.
References
[1] Patent: US2013/20532, 2013, A1. Location in patent: Paragraph 0042
[2] Journal of Materials Chemistry C, 2014, vol. 2, # 5, p. 891 - 900
2,3-Difluorophenylboronic acid Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Youji Materials Co., Ltd | 13052376889 13681663468 | 2851911691@qq.com | China | 823 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shijiazhuang Sdyano Fine Chemical Co., Ltd. | 0311-89250318 13582355795 | master@sjzsdyn.com | China | 2776 | 65 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 |
View Latest Price from 2,3-Difluorophenylboronic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-25 | 2,3-Difluorophenylboronic acid
121219-16-7
|
$2.20-8.80 | 1kg | 99% | 1000kg | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | |
 |
2026-05-28 | 2,3-Difluorophenylboronic acid
121219-16-7
|
$9.00 | 1KG | 99.9 | 1 ton | Hebei Chuanghai Biotechnology Co,.LTD | |
 |
2023-09-07 | 2,3-Difluorophenylboronic acid
121219-16-7
|
$30.00 | 1kg | 99% | 1000t/year | Anhui Ruihan Technology Co., Ltd |
-
- 2,3-Difluorophenylboronic acid
121219-16-7
- $2.20-8.80
- 99%
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
-
- 2,3-Difluorophenylboronic acid
121219-16-7
- $9.00
- 99.9
- Hebei Chuanghai Biotechnology Co,.LTD
-
- 2,3-Difluorophenylboronic acid
121219-16-7
- $30.00
- 99%
- Anhui Ruihan Technology Co., Ltd
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