Methyl pyruvate
- CAS No.
- 600-22-6
- Chemical Name:
- Methyl pyruvate
- Synonyms
- METHYL 2-OXOPROPANOATE;Propanoic acid, 2-oxo-, methyl ester;PAME;Methyl acetoformate;ksby;PYR ME;METHYL PYRUVATE;Methyl pyruyate;MethylPyruvate>Methylpyruvate,96%
- CBNumber:
- CB8405108
- Molecular Formula:
- C4H6O3
- Molecular Weight:
- 102.09
- MDL Number:
- MFCD00008754
- MOL File:
- 600-22-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | -22 °C |
|---|---|
| Boiling point | 134-137 °C (lit.) |
| Density | 1.13 g/mL at 25 °C (lit.) |
| refractive index |
n |
| FLAVIS Number | 09.626 | Methyl 2-oxopropionate |
| Flash point | 103 °F |
| storage temp. | 2-8°C |
| solubility | ethanol: soluble1.1g/10 mL, clear, colorless to almost colorless |
| form | liquid |
| color | Yellow |
| Water Solubility | Soluble in chloroform, methanol, ether, alcohol. Slightly soluble in water. |
| Merck | 14,8021 |
| BRN | 1361953 |
| InChI | 1S/C4H6O3/c1-3(5)4(6)7-2/h1-2H3 |
| InChIKey | CWKLZLBVOJRSOM-UHFFFAOYSA-N |
| SMILES | COC(=O)C(C)=O |
| LogP | -0.159 (est) |
| CAS DataBase Reference | 600-22-6(CAS DataBase Reference) |
| FDA UNII | 3KJM65G5XL |
| NIST Chemistry Reference | Propanoic acid, 2-oxo-, methyl ester(600-22-6) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS02 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H226 | |||||||||
| Precautionary statements | P261 | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | Xi,F | |||||||||
| Risk Statements | 10 | |||||||||
| Safety Statements | 23-24/25-16 | |||||||||
| RIDADR | UN 3272 3/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 10-21 | |||||||||
| HazardClass | 3 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29183000 | |||||||||
| Storage Class | 3 - Flammable liquids | |||||||||
| Hazard Classifications | Flam. Liq. 3 | |||||||||
| REACH Registrations | Active | |||||||||
| Limited Quantities | 5.0 L (1.3 gallons) (liquid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
Methyl pyruvate price More Price(43)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 371173 | Methyl pyruvate 90%, technical grade | 600-22-6 | 25g | $42.7 | 2026-04-30 | Buy |
| Sigma-Aldrich | 371173 | Methyl pyruvate 90%, technical grade | 600-22-6 | 100g | $124 | 2026-04-30 | Buy |
| TCI Chemical | P0580 | Methyl Pyruvate >97.0%(GC) | 600-22-6 | 25mL | $38 | 2026-04-30 | Buy |
| TCI Chemical | P0580 | Methyl Pyruvate >97.0%(GC) | 600-22-6 | 500mL | $186 | 2026-04-30 | Buy |
| TRC | TRC-M326980-50G | Methyl Pyruvate | 600-22-6 | 50g | $154 | 2026-06-03 | Buy |
Methyl pyruvate Chemical Properties, Uses, Production
Chemical Properties
Methyl pyruvate is a clear, light yellow, and flammable liquid.
Uses
Methyl Pyruvate acts as a potent secretagogue used in the study of stimulus-secretion coupling. Also used in the preparation of quinoxalines as dual phoosphodiesterase 2/10 (PDE2/10) inhibitors. It increases free calcium ion concentration in the cytosol of pancreatic cells. It is used in the preparation of dimethyl 2,3-dimethylenebutanedioate.
Uses
Methyl pyruvate may be used to investigate the adsorption and reactivity of methyl pyruvate on Pt{111}. It may be used in the preparation of dimethyl 2,3-dimethylenebutanedioate.
Definition
ChEBI: Methyl pyruvate is a pyruvate ester resultinf grom the formal condensation of the carboxy group of pyruvic acid with the hydroxy group of methanol. It is a pyruvate ester and a methyl ester. It derives from a pyruvic acid.
Preparation
Methyl pyruvate has been prepared from the silver salt of pyruvic acid and methyl iodide; from the free acid, by the ethanol-vapor method without a catalyst, by azeotropic removal of the water produced by the reaction of methanol in the presence of p-toluenesulfonic acid (the present method), and by refluxing with methanol in ethylene dichloride using ethanesulfonic acid as a catalyst (73% yield). Pyruvic esters have also been prepared by the catalytic dehydrogenation of lactic acid esters and by the oxidation of ethyl lactate with potassium permanganate.
DOI: 10.15227/orgsyn.024.0072
General Description
Methyl pyruvate is a pyruvic ester. Surface conditions during Pt/silica EUROPT-1 modified by cinchonidine catalyzed by enantioselective hydrogenation of methyl pyruvate to R-(+)-methyl lactate were investigated. Enantioselective hydrogenation of methyl pyruvate over finely dispersed polyvinylpyrrolidone-stabilized and the corresponding alumina-supported iridium clusters modified with cinchonidine was studied. The molecular orientation and conformation of methyl pyruvate on Ni(111) surface has been investigated in the temperature range 105-220K. Methyl pyruvate is reported to stimulate insulin secretion in vitro and in vivo.
Methyl pyruvate Preparation Products And Raw materials
Raw materials
1of3
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Lansun Biochemistry Pharmaceutical Co., Ltd. | 0714-6395977 18062294810 | 270218286@qq.com | China | 4 | 58 |
| Hangzhou Baiji Biotechnology Co., LTD | 13615701454 | 616495203@qq.com | China | 24 | 58 |
| SHANGHAI SAGACHEM CO., LTD. | 021-68404722 13816115801 | david_si@shjlchem.com | China | 228 | 58 |
| Hubei Ruitai Pharmaceutical Technology Co.,Ltd. | 15335880183 | ywcyt@126.com | China | 12 | 58 |
| HuBei ShengBaoLai Biological Technology Co., Ltd | 027-59105235 13007105135 | sbl1120@163.com | China | 96 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9407 | 55 |
View Latest Price from Methyl pyruvate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-03-20 | DISPERSE YELLOW 82
12239-58-6
|
$10.00 | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2025-06-27 | Methyl pyruvate
600-22-6
|
1KG | 99% | 500000kg | Hebei Chuanghai Biotechnology Co., Ltd | ||
 |
2025-06-20 | Methyl pyruvate
600-22-6
|
$50.00 | 1kg | 0.99 | 10000 | Hebei Yanxi Chemical Co., Ltd. |
-
- DISPERSE YELLOW 82
12239-58-6
- $10.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- Methyl pyruvate
600-22-6
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- Methyl pyruvate
600-22-6
- $50.00
- 0.99
- Hebei Yanxi Chemical Co., Ltd.
