2,2-Dimethoxypropionic acid methyl ester
- CAS No.
- 10076-48-9
- Chemical Name:
- 2,2-Dimethoxypropionic acid methyl ester
- Synonyms
- METHYL PYRUVATE DIMETHYL ACETAL;METHYL 2,2-DIMETHOXYPROPIONATE;METHYL 2,2-DIMETHOXYPROPANOATE;Methyl2,2-Dimethoxypropionate>Dimethoxypropionicacidmethylester;2,2-Dimethoxypropionic acid methyl ester;Propanoic acid, 2,2-dimethoxy-, methyl ester;2,2-DIMETHOXYPROPIONIC ACID METHYL ESTER, 96+%
- CBNumber:
- CB0755447
- Molecular Formula:
- C6H12O4
- Molecular Weight:
- 148.16
- MDL Number:
- MFCD00048066
- MOL File:
- 10076-48-9.mol
- MSDS File:
- SDS
| Boiling point | 70 °C / 13mmHg |
|---|---|
| Density | 1.07 |
| refractive index | 1.4100-1.4120 |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| form | clear liquid |
| color | Colorless to Almost colorless |
| CAS DataBase Reference | 10076-48-9 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H227 |
| Precautionary statements | P210-P280-P370+P378-P403+P235-P501 |
| HS Code | 2918.19.9000 |
2,2-Dimethoxypropionic acid methyl ester price More Price(33)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | D2382 | Methyl 2,2-Dimethoxypropionate >96.0%(GC) | 10076-48-9 | 25g | $191 | 2026-04-30 | Buy |
| Biosynth | KAA07648 | Methyl 2,2-Dimethoxypropionate | 10076-48-9 | 10g | $251.3 | 2026-06-04 | Buy |
| Biosynth | KAA07648 | Methyl 2,2-Dimethoxypropionate | 10076-48-9 | 25g | $392.75 | 2026-06-04 | Buy |
| Biosynth | KAA07648 | Methyl 2,2-Dimethoxypropionate | 10076-48-9 | 50g | $707 | 2026-06-04 | Buy |
| Biosynth | KAA07648 | Methyl 2,2-Dimethoxypropionate | 10076-48-9 | 100g | $1257 | 2026-06-04 | Buy |
2,2-Dimethoxypropionic acid methyl ester Chemical Properties, Uses, Production
Synthesis
600-22-6
149-73-5
10076-48-9
General procedure for the synthesis of methyl 2,2-dimethoxypropionate from methyl pyruvate and trimethyl orthoformate: 100 g (979 mmol) of methyl pyruvate was mixed with 135 g (1273 mmol) of trimethyl orthoformate in 240 ml of methanol. After adding 0.96 g (9.79 mmol) of concentrated sulfuric acid, the mixture was heated to reflux for 4 hours. Subsequently, the solvent was distilled out over 2 h. The crude product was cooled to 10 °C and added to a solution of 2.4 g of potassium hydroxide in 1200 ml of water at 10 °C. After repeated extraction with ether, the organic phases were combined and dried over anhydrous sodium sulfate, filtered and concentrated. The residue was distilled under reduced pressure and the fractions with boiling points of 50-55°C (10 mbar) were collected. Finally 118 g (77% yield) of the target product was obtained.1H NMR (CDCl3) data were as follows: δ = 1.53 (s, 3H, C-CH3), 3.29 (s, 6H, CH3-OCO-CH3), 3.82 (s, 3H, COOCH3).
References
[1] Journal of the American Chemical Society, 1983, vol. 105, # 7, p. 2021 - 2029
[2] Patent: US2015/245616, 2015, A1. Location in patent: Paragraph 0189; 0190
2,2-Dimethoxypropionic acid methyl ester Preparation Products And Raw materials
Raw materials
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Preparation Products
2,2-Dimethoxypropionic acid methyl ester Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9407 | 55 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Maya High Purity Chemicals | +86 (573) 82222445 (0)18006601000 452520369 | sales@maya-r.com | China | 11693 | 57 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 13913916777 | cfzhang@aikonchem.com | China | 19902 | 55 |
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28364 | 80 |
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