N-Hydroxybenzenecarboximidoyl chloride
- CAS No.
- 698-16-8
- Chemical Name:
- N-Hydroxybenzenecarboximidoyl chloride
- Synonyms
- N-Hydroxybenzimidoyl chloride;ALPHA-CHLOROBENZALDOXIME;-Chlorobenzaldoxime;A-CHLOROBENZALDOXIME;o-Chlorobenzaldoxime;α-Chlorobenzaldoxime;Cloxacillin Impurity 8;BenzohydroximoylChloride;-Chlorobenzaldehydeoxime;α-chlorobenzaldehyde oxime
- CBNumber:
- CB8408972
- Molecular Formula:
- C7H6ClNO
- Molecular Weight:
- 155.58
- MDL Number:
- MFCD02183500
- MOL File:
- 698-16-8.mol
- MSDS File:
- SDS
| Melting point | 48-52°C |
|---|---|
| Boiling point | 275.8±23.0 °C(Predicted) |
| Density | 1.21±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| pka | 10.51±0.70(Predicted) |
| Appearance | White to light brown Solid |
| CAS DataBase Reference | 698-16-8(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P271-P261 |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36/37/39 |
| HS Code | 2928009090 |
N-Hydroxybenzenecarboximidoyl chloride price More Price(48)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | AAA69816 | a-Chlorobenzaldoxime | 698-16-8 | 5g | $437.5 | 2026-06-04 | Buy |
| Apolloscientific | OR322225 | alpha-chlorobenzaldoxime ≥95% | 698-16-8 | 250mg | $30 | 2026-06-04 | Buy |
| Apolloscientific | OR322225 | alpha-chlorobenzaldoxime ≥95% | 698-16-8 | 500mg | $35 | 2026-06-04 | Buy |
| Apolloscientific | OR322225 | alpha-chlorobenzaldoxime ≥95% | 698-16-8 | 1g | $58 | 2026-06-04 | Buy |
| Matrix Scientific | 306138 | N-Hydroxybenzimidoyl chloride | 698-16-8 | 1.00g | $82 | 2026-05-19 | Buy |
N-Hydroxybenzenecarboximidoyl chloride Chemical Properties, Uses, Production
Chemical Properties
Colorless crystals
Synthesis
932-90-1
698-16-8
1-B. Preparation of N-hydroxybenzimidoyl chloride: refer to the method of Liu, K.C. et al. (J. Org. Chem., 45: 3916-1918, 1980). N-chlorosuccinimide (26.9 g, 201 mmol) was added to a solution of (E)-benzaldehyde oxime (24.4 g, 201 mmol) in N,N-dimethylformamide (60 mL) in batches at room temperature. After each addition, the reaction mixture first turns yellow and then gradually returns to nearly colorless. Note that the reaction is exothermic and batch addition of N-chlorosuccinimide is required to ensure smooth initiation of the reaction. If necessary, the reaction temperature can be controlled with an ice bath. After addition, the reaction mixture was stirred at room temperature overnight. After completion of the reaction, dilute with 250 mL of water and extract with ether (3 x 100 mL). The organic layers were combined and washed sequentially with water (2 x 100 mL), 10% aqueous lithium chloride (2 x 100 mL) and brine (100 mL). The aqueous layer was then back-extracted with ether (100 mL), and all organic layers were combined (about 400 mL) and dried over anhydrous sodium sulfate. Concentration under reduced pressure afforded (Z)-N-hydroxybenzenecarbamoyl chloride (30.84 g, 198 mmol, 98% yield) as a fluffy light yellow solid. The product was analyzed by HPLC (column: CHROMOLITH SpeedROD 4.6×50 mm; mobile phase A: 10% MeOH, 90% H2O, 0.1% TFA; mobile phase B: 90% MeOH, 10% H2O, 0.1% TFA; run time: 4 min) with a retention time of 1.57 min. LC/MS (M+1) = 155.8. 1H NMR (500 MHz, DMSO-d6) δ 7.30-7.64 (m, 3H), 7.73-7.87 (m, 2H), 12.42 (s, 1H).
References
[1] Patent: WO2010/85581, 2010, A1. Location in patent: Page/Page column 48-49
[2] Chemische Berichte, 1894, vol. 27, p. 2198
[3] Chemische Berichte, 1902, vol. 35, p. 3115
[4] Justus Liebigs Annalen der Chemie, 1927, vol. 451, p. 166
[5] Chemische Berichte, 1914, vol. 47, p. 2943
N-Hydroxybenzenecarboximidoyl chloride Preparation Products And Raw materials
Raw materials
Preparation Products
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| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
| Zhengzhou Kingsfine Chemical Co., Ltd. | 0371-56635027 13838252817 | sales@kingsfine.com | China | 100 | 62 |
| Sci General Material & Chemical Ltd | 021-58388037;21-58388037 13472507714 | 35177634@qq.com;1589045147@qq.com | China | 795 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| ShangHai D&B Biological Science and Technology Co.Ltd | 400-008-9730,021-54359730 400-008-9730 | info@chemxyz.com | China | 3642 | 60 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66028182 17714375163 | yftan@aikonchem.com | China | 16674 | 50 |
| Shanghai Tombiopharma Chemical Co. Ltd. | 13391076197 | tombiopharma@163.com | China | 4986 | 55 |
| Zhengzhou Guancheng Laboratory equipment Sales | 0371-88888888 qq272369594;2159423853qq | 2723695949@qq.com | China | 4990 | 50 |
View Latest Price from N-Hydroxybenzenecarboximidoyl chloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | alpha-Chlorobenzaldoxime
698-16-8
|
$1.00 | 1kg | 98% | 200kg | Career Henan Chemical Co |
-
- alpha-Chlorobenzaldoxime
698-16-8
- $1.00
- 98%
- Career Henan Chemical Co
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