8-HYDROXYJULOLIDINE
- CAS No.
- 41175-50-2
- Chemical Name:
- 8-HYDROXYJULOLIDINE
- Synonyms
- 2,3,6,7-TETRAHYDRO-1H,5H-PYRIDO[3,2,1-IJ]QUINOLIN-8-OL;AKOS BBS-00000819;8-HYDROXYJULOLIDINE;TIMTEC-BB SBB006615;8-HydroxyIulolidineHCl;8-Hydroxyjulolidine>8-Hydroxyjulolidine,98%;8-HYDROXYJULOLIDINE HYDROCHLORIDE;2,3,6,7-TETRAHYDRO-1H,5H-BENZO[I,J]-QUIN;1,2,3,5,6,7-Hexahydropyrido[3,2,1-ij]quin
- CBNumber:
- CB8445281
- Molecular Formula:
- C12H15NO
- Molecular Weight:
- 189.25
- MDL Number:
- MFCD00006918
- MOL File:
- 41175-50-2.mol
| Product description | Number | Pack Size | Price |
| 8-Hydroxyjulolidine 97% | 249394 | 1g | $107 |
| 8-Hydroxyjulolidine 97% | 249394 | 5g | $348.65 |
| 8-Hydroxyjulolidine >97.0%(HPLC)(T) | H0928 | 1g | $55 |
| 8-Hydroxyjulolidine >97.0%(HPLC)(T) | H0928 | 5g | $187 |
| 8-Hydroxyjulolidine | H943675 | 250mg | $145 |
| More product size | |||
| Melting point | 132-134 °C(lit.) |
|---|---|
| Boiling point | 374.4±41.0 °C(Predicted) |
| Density | 1.22±0.1 g/cm3(Predicted) |
| storage temp. | room temp |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| pka | 11.25±0.20(Predicted) |
| form | Solid |
| color | White to Pink |
| Water Solubility | Soluble in water (partly), ethanol, chloroform, methanol, and acetone. |
| BRN | 1530423 |
| InChI | InChI=1S/C12H15NO/c14-11-6-5-9-3-1-7-13-8-2-4-10(11)12(9)13/h5-6,14H,1-4,7-8H2 |
| InChIKey | FOFUWJNBAQJABO-UHFFFAOYSA-N |
| SMILES | C12=CC=C(O)C3=C1N(CCC3)CCC2 |
| CAS DataBase Reference | 41175-50-2(CAS DataBase Reference) |
| FDA UNII | SDF5635X33 |
| EPA Substance Registry System | 1H,5H-Benzo[ij]quinolizin-8-ol, 2,3,6,7-tetrahydro- (41175-50-2) |
| UNSPSC Code | 12352104 |
| NACRES | NA.47 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 22-24/25-37/39-26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 10 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 2933 99 80 | |||||||||
| NFPA 704 |
|
8-HYDROXYJULOLIDINE price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 249394 | 8-Hydroxyjulolidine 97% | 41175-50-2 | 1g | $107 | 2025-07-31 | Buy |
| Sigma-Aldrich | 249394 | 8-Hydroxyjulolidine 97% | 41175-50-2 | 5g | $348.65 | 2025-07-31 | Buy |
| TCI Chemical | H0928 | 8-Hydroxyjulolidine >97.0%(HPLC)(T) | 41175-50-2 | 1g | $55 | 2025-07-31 | Buy |
| TCI Chemical | H0928 | 8-Hydroxyjulolidine >97.0%(HPLC)(T) | 41175-50-2 | 5g | $187 | 2025-07-31 | Buy |
| TRC | H943675 | 8-Hydroxyjulolidine | 41175-50-2 | 250mg | $145 | 2021-12-16 | Buy |
8-HYDROXYJULOLIDINE Chemical Properties,Uses,Production
Chemical Properties
pink to beige or brown fine crystalline powder
Uses
8-Hydroxyjulolidine is used as an intermediate in the preparation of aminocoumarins via microwave-accelerated Pechmann reaction. It is also employed as a starting material for coumarin C-ribosides.
Uses
8-Hydroxyjulolidine has been used in the electrochemical switching fluorescence study.
General Description
The carboxaldehyde derivative of 8-hydroxyjulolidine is useful as a chromophore in fluorescence chemosensor and chemosensors.
Synthesis
63468-83-7
41175-50-2
The general procedure for the synthesis of 1,2,3,5,6,7-hexahydropyrido[3,2,1-ij]quinolin-8-ol from 8-methoxyjulolidine was as follows: 8-methoxyjulolidine (10 g, 50 mmol) was dissolved in a mixed solution consisting of 50 mL of 47% hydriodic acid, 80 mL of concentrated hydrochloric acid and 200 mL of water. The reaction mixture was heated to reflux and the progress of the reaction was monitored by thin layer chromatography (TLC). After 15 hours of reaction, 50 mL of concentrated hydrochloric acid was added to the mixture. The total reaction time was 60 hours. Upon completion of the reaction, the solution was cooled in an ice bath and first neutralized to pH 6 with 50% sodium hydroxide solution, followed by the addition of phosphate buffer (prepared by dissolving 6.9 g NaH2PO4-H2O and 1.4 g Na2HPO4 in 100 mL of water). The product was extracted with dichloromethane and the organic phase was washed with brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure to remove the solvent. The resulting crude product was redissolved in dichloromethane and extracted repeatedly with 10% sodium hydroxide solution until the aqueous phase was colorless. Subsequently, the organic phase was acidified, dried and extracted again, and the solvent was removed as described above, resulting in the product 1,2,3,5,6,7-hexahydropyrido[3,2,1-ij]quinolin-8-ol (6.24 g) in 67% yield and with a melting point of 126-130°C. The product was extracted with sodium sulfate under reduced pressure.
References
[1] Journal of Organic Chemistry, 1987, vol. 52, # 8, p. 1465 - 1468
[2] Journal of Fluorescence, 2015, vol. 25, # 6, p. 1615 - 1628
[3] Chemical Communications, 2011, vol. 47, # 47, p. 12691 - 12693
[4] Chemistry - A European Journal, 2014, vol. 20, # 12, p. 3510 - 3519
[5] Patent: US2018/280543, 2018, A1. Location in patent: Paragraph 0041; 0098
8-HYDROXYJULOLIDINE Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Dideu Medichem Co. Ltd | +86-29-81148696 +86-17392712697 | 1022@dideu.com | China | 3996 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20183 | 58 |
| Springchem New Material Technology Co.,Limited | +86-021-62885108 +8613917661608 | info@spring-chem.com | China | 2068 | 57 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29852 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10406 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49975 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 12089 | 58 |
| Shanghai Rlavie Technology Co ltd | +86-021-67759270 +8617717059219 | sales@rlavie.com | China | 1030 | 58 |
View Lastest Price from 8-HYDROXYJULOLIDINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-09-25 | 8-Hydroxyjulolidine
41175-50-2
|
US $200.00-1.00 / KG | 1KG | 99%, 99.5% Sublimated | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2025-07-25 | 8-HYDROXYJULOLIDINE
41175-50-2
|
US $0.00-0.00 / kg | 1kg | 98% | kgs | Shaanxi Dideu New Materials Co. Ltd | |
 |
2024-08-05 | 8-HYDROXYJULOLIDINE
41175-50-2
|
US $0.10 / KG | 1KG | 98.0% | 10 | Shaanxi Dideu Medichem Co. Ltd |
-
- 8-Hydroxyjulolidine
41175-50-2
- US $200.00-1.00 / KG
- 99%, 99.5% Sublimated
- Henan Fengda Chemical Co., Ltd
-
- 8-HYDROXYJULOLIDINE
41175-50-2
- US $0.00-0.00 / kg
- 98%
- Shaanxi Dideu New Materials Co. Ltd
-
- 8-HYDROXYJULOLIDINE
41175-50-2
- US $0.10 / KG
- 98.0%
- Shaanxi Dideu Medichem Co. Ltd
