5-Amino-2-Boc-1,2,3,4-tetrahydroisoquinoline
- CAS No.
- 201150-73-4
- Chemical Name:
- 5-Amino-2-Boc-1,2,3,4-tetrahydroisoquinoline
- Synonyms
- 2(1H)-Isoquinolinecarboxylic acid, 5-amino-3,4-dihydro-, 1,1-dimethylethyl ester;CAS:201150-73-4;2-Boc-1,2,3,4-Tetrahydroisoquinolin;2-BOC-1,2,3,4-TETRAHYDROISOQUINOLIN-5-AMINE;5-Amino-2-Boc-1,2,3,4-tetrahydroisoquinoline;5-AMINO-N-T-BUTYLOXYCARBONYL-1,2,3,4-TETRAHYDROISOQUINOLINE;5-AMINO-2-TERT-BUTOXYCARBONYL-1,2,3,4-TETRAHYDROISOQUINOLINE;tert-butyl 5-amino-3,4-dihydro-1H-isoquinoline-2-carboxylate;TERT-BUTYL 5-AMINO-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE;tert-Butyl 5-amino-1,2,3,4-tetrahydroisoquinoline-2-carboxylate
- CBNumber:
- CB8446930
- Molecular Formula:
- C14H20N2O2
- Molecular Weight:
- 248.32
- MDL Number:
- MFCD02179750
- MOL File:
- 201150-73-4.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS02 |
|---|---|
| Signal word | Danger |
| Hazard statements | H225 |
| Precautionary statements | P501-P240-P210-P233-P243-P241-P242-P280-P370+P378-P303+P361+P353-P403+P235 |
| HazardClass | IRRITANT |
5-Amino-2-Boc-1,2,3,4-tetrahydroisoquinoline price More Price(53)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | FA148149 | 5-Amino-2-tert-butoxycarbonyl-1,2,3,4-tetrahydroisoquinoline | 201150-73-4 | 0.25g | $250 | 2026-06-04 | Buy |
| Biosynth | FA148149 | 5-Amino-2-tert-butoxycarbonyl-1,2,3,4-tetrahydroisoquinoline | 201150-73-4 | 0.1g | $250 | 2026-06-04 | Buy |
| Biosynth | FA148149 | 5-Amino-2-tert-butoxycarbonyl-1,2,3,4-tetrahydroisoquinoline | 201150-73-4 | 0.05g | $250 | 2026-06-04 | Buy |
| Biosynth | FA148149 | 5-Amino-2-tert-butoxycarbonyl-1,2,3,4-tetrahydroisoquinoline | 201150-73-4 | 0.5g | $259.6 | 2026-06-04 | Buy |
| Biosynth | FA148149 | 5-Amino-2-tert-butoxycarbonyl-1,2,3,4-tetrahydroisoquinoline | 201150-73-4 | 1g | $415.36 | 2026-06-04 | Buy |
5-Amino-2-Boc-1,2,3,4-tetrahydroisoquinoline Chemical Properties,Uses,Production
Synthesis
115955-90-3
24424-99-5
201150-73-4
To a 1,4-dioxane (100 mL) solution of 5-amino-1,2,3,4-tetrahydroisoquinoline (3.68 g, 24.8 mmol) was added an aqueous 3 N NaOH solution (8.27 mL, 24.8 mmol). After the reaction mixture was cooled to 0°C, a solution of 1,4-dioxane (10 mL) in di-tert-butyl dicarbonate (5.42 g, 24.8 mmol) was added slowly and dropwise. After the dropwise addition, the reaction mixture was stirred at room temperature overnight. After completion of the reaction, the mixture was poured into water and extracted with ethyl acetate (2×). The organic layers were combined and washed sequentially with saturated aqueous NaHCO3 solution, water and brine. The organic layer was dried over anhydrous Na2SO4 and concentrated under reduced pressure. The residue was purified by silica gel column chromatography to afford 5.44 g (88% yield) of tert-butyl 5-amino-3,4-dihydroisoquinoline-2(1H)-carboxylate of the target compound as a white solid.
References
[1] Patent: WO2005/37214, 2005, A2. Location in patent: Page/Page column 121-122
[2] Bioorganic and Medicinal Chemistry, 2000, vol. 8, # 8, p. 2085 - 2094
[3] Patent: WO2014/160668, 2014, A1. Location in patent: Page/Page column 357
5-Amino-2-Boc-1,2,3,4-tetrahydroisoquinoline Preparation Products And Raw materials
Raw materials
Preparation Products
5-Amino-2-Boc-1,2,3,4-tetrahydroisoquinoline Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| PharmaBlock Sciences (Nanjing),Inc. | 025-86918202 4000255188 | sales@pharmablock.com | China | 5000 | 55 |
| ITIC MEDCHEM(SUZHOU) CO.,LTD. | 0512-68323967 18015559028 | sales@iticmedchem.com | China | 528 | 61 |
| Shanghai Litong Chemical Technology Co.,Ltd. | 13598610367 0373-7129549 | 2468833170@qq.com | China | 932 | 58 |
| SuZhou ShiYa Biopharmaceuticals, Inc. | 86(512)5235 8471 17715136450 | sales@shiyabiopharm.com | China | 4167 | 58 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Nantong MYBio-pharm. Co., Ltd. | 0513-85921823 18662920231 | sales@ntminyanmedical.com | China | 4545 | 58 |
| Shanghai Worldyang Chemical Co.,Ltd. | 021-56795766 | sales@worldyachem.com | China | 9475 | 58 |
| HangZhou YuHao Chemical Technology Co., Ltd. | 0571-82693216 | info@yuhaochemical.com | China | 1999 | 58 |
| JW & Y Pharmlab Co., Ltd. | 021-64340559 | xinyu_shi@jwypharmlab.com.cn | China | 11999 | 58 |
