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2,3-Difluoroaniline

2,3-Difluoroaniline structure

CAS No.: 4519-40-8

Chemical Name:: 2,3-Difluoroaniline

Synonyms: 2,3-Difluorobenzenamine;2,3-DIFLUOROANILINE;TIMTEC-BB SBB006565;2,3-Difluoroaniline>2,3- twofluoro aniline;2,3-difluorophenylamine;2,3-Difluoroaniline,98%;2,3-Difluoroaniline 98%;Benzenamine, 2,3-difluoro-;2,3-Difluoroaniline, 98% 1GR

CBNumber:: CB8453088

Molecular Formula:: C6H5F2N

Molecular Weight:: 129.11

MDL Number:: MFCD00010298

MOL File:: 4519-40-8.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 03:18:37

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2,3-Difluoroaniline Properties

Boiling point	68-69 °C
Density	1.274 g/mL at 25 °C (lit.)
refractive index	n20/D 1.514(lit.)
Flash point	160 °F
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
pka	2.19±0.10(Predicted)
form	Liquid
Specific Gravity	1.274
color	Clear light orange
BRN	2716500
InChI	InChI=1S/C6H5F2N/c7-4-2-1-3-5(9)6(4)8/h1-3H,9H2
InChIKey	YCCQGFYAVUTQFK-UHFFFAOYSA-N
SMILES	C1(N)=CC=CC(F)=C1F
CAS DataBase Reference	4519-40-8(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302+H312+H332-H315-H319-H335

Precautionary statements

P261-P280-P301+P312-P302+P352+P312-P304+P340+P312-P305+P351+P338

target organs

Respiratory system

PPE

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Hazard Codes

Xn,Xi

Risk Statements

20/21/22-36/37/38

Safety Statements

26-27-28-36/37/39-36

RIDADR

2941

WGK Germany

Hazard Note

Irritant

HazardClass

6.1

PackingGroup

III

HS Code

29214200

Storage Class

10 - Combustible liquids

Hazard Classifications

Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

Limited Quantities

5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid)

Excepted Quantities

Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)

NFPA 704

	1
2		0

2,3-Difluoroaniline price More Price(57)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	265306	2,3-Difluoroaniline 98%	4519-40-8	5g	$70.7	2026-04-30	Buy
TCI Chemical	D2595	2,3-Difluoroaniline >97.0%(GC)	4519-40-8	1g	$22	2026-04-30	Buy
TCI Chemical	D2595	2,3-Difluoroaniline >97.0%(GC)	4519-40-8	5g	$72	2026-04-30	Buy
Biosynth	FD64332	2,3-Difluoroaniline	4519-40-8	100g	$389	2026-06-04	Buy
Biosynth	FD64332	2,3-Difluoroaniline	4519-40-8	250g	$780	2026-06-04	Buy

Product number	Packaging	Price	Buy
265306	5g	$70.7	Buy
D2595	1g	$22	Buy
D2595	5g	$72	Buy
FD64332	100g	$389	Buy
FD64332	250g	$780	Buy

2,3-Difluoroaniline Chemical Properties, Uses, Production

Chemical Properties

clear light orange liquid

Uses

2,3-Difluoroaniline was used in the synthesis of ethyl 2-arylamino-4-trifluoromethylpyrimidine-5-carboxylate.

Uses

intermediate for liquid crystal and drugs

Synthesis

1481-57-8

4519-40-8

The general procedure for the synthesis of 2,3-difluoroaniline from 2,3-dibromo-5,6-difluoronitrobenzene was as follows: first, 0.638 g (2.01 mmol) of 2,3-dibromo-5,6-difluoronitrobenzene was dissolved in 4 mL of methanol. Subsequently, 48.4 mg of 10% Pd/C (50% wet) catalyst and 6.2 mg (0.06 mmol) of triethylamine were added to the solution. The atmosphere in the reaction vessel was replaced with hydrogen and the reaction mixture was stirred at 50 °C for 2 h under slight hydrogen pressure. The reaction mixture was analyzed by HPLC, which showed the presence of 2.2 area% of 2,3-dibromo-5,6-difluoroaniline as a residual intermediate. The reaction was continued under the same conditions for 0.5 hours. After completion of the reaction, the catalyst was removed by filtration. The resulting liquid was quantitatively analyzed by HPLC and the yield of 2,3-difluoroaniline was measured to be 93% and the intermediate 2,3-dibromo-5,6-difluoroaniline was completely consumed.

References

[1] Patent: EP2940002, 2015, A1. Location in patent: Paragraph 0075

2,3-Difluoroaniline synthesis

Synthesis of 2,3-Difluoroaniline from 1,2-Dibromo-4,5-difluoro-3-nitrobenzene

2,3-Difluoroaniline Preparation Products And Raw materials

Raw materials

1,2-Dibromo-4,5-difluoro-3-nitrobenzene Triethylamine Palladium Methanol Hydrogen

Activated carbon

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Preparation Products

4-Bromo-2,3-difluoroaniline 7-Fluoro-3H-benzothiazole-2-thione 7,8-Difluoro-4-hydroxyquinoline-3-carboxylic acid ethyl ester 2-Chloro-7-fluorobenzothiazole 2,3-difluorobenzene-1-sulfonamide

2,3-Difluoroaniline Suppliers

Global Suppliers ( 364)

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Harvest Chemical Industrial Co., Ltd.	15721252604 17321035817	sales@harvest-chem.com	China	2829	64
Cool Pharm, Ltd	021-58581007 18019463053	sales@coolpharm.com	China	9999	58
Beijing Bankchem Pharmatech Co.,Ltd.	010-80236392 17600588818	bankchem@163.com	China	247	58
Henan Evonik Biotechnology Co. LTD	15672878902	hnyingchuang@163.com	China	4039	58
FUXIN QINGJISHENG SCIENCE AND TECHNOLOGY CO.,LID	15940530539 15396717197	361811402@qq.com	China	669	58
Henan Yinuokai New Materials Co., Ltd	15565215982 15565215982	15565215982@163.com	China	3783	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81

Supplier	Advantage
Shanghai Harvest Chemical Industrial Co., Ltd.	64
Cool Pharm, Ltd	58
Beijing Bankchem Pharmatech Co.,Ltd.	58
Henan Evonik Biotechnology Co. LTD	58
FUXIN QINGJISHENG SCIENCE AND TECHNOLOGY CO.,LID	58
Henan Yinuokai New Materials Co., Ltd	58
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
Alfa Aesar	84
TCI (Shanghai) Development Co., Ltd.	81

View Latest Price from 2,3-Difluoroaniline manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-02	2,3-Difluoroaniline 4519-40-8	$5.00	1KG	98%		Henan Fengda Chemical Co., Ltd
2026-05-28	2,3-Difluoroaniline 4519-40-8	$10.50	1KG	99%	10 ton	Hebei Chuanghai Biotechnology Co,.LTD
2025-04-04	2,3-Difluoroaniline 4519-40-8		1KG	98%	1ton	Henan Aochuang Chemical Co.,Ltd.

2,3-Difluoroaniline
4519-40-8
$5.00
98%
Henan Fengda Chemical Co., Ltd

2,3-Difluoroaniline
4519-40-8
$10.50
99%
Hebei Chuanghai Biotechnology Co,.LTD

2,3-Difluoroaniline
4519-40-8
98%
Henan Aochuang Chemical Co.,Ltd.

2,3-Difluoroaniline Spectrum

2,3-Difluoroaniline(4519-40-8)MS 2,3-Difluoroaniline(4519-40-8)¹HNMR 2,3-Difluoroaniline(4519-40-8)¹³CNMR 2,3-Difluoroaniline(4519-40-8)IR1 2,3-Difluoroaniline(4519-40-8)Raman

4519-40-8 (2,3-Difluoroaniline) Related Search:

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2-Bromo-4,5-difluoroaniline 3-Chloro-2,6-difluoroaniline 2,4-Difluoroaniline 2,5-Difluoroaniline 2,6-Difluoroaniline

Pentafluoronitrobenzene 4-Amino-2,3,5,6-tetrafluorobenzoic acid 4-Amino-2,3,5,6-tetrafluorobenzonitrile

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2,3-DIFLUOROANILINE 2,3-Difluorobenzenamine TIMTEC-BB SBB006565 2,3-Difluoroaniline 98% 2,3-Difluoroaniline,98% 2,3-difluorophenylamine Benzenamine, 2,3-difluoro- 2,3-Difluoroaniline, 98% 1GR 2,3- twofluoro aniline 2,3-Difluoroaniline> 2,3-Difluoroaniline ISO 9001：2015 REACH 4519-40-8 6418-38-3 C6H5F2N Building Blocks Amines C2 to C6 Organic Building Blocks Nitrogen Compounds AMINE Fluorobenzene Series Other fluorin-contained compounds Anilines, Aromatic Amines and Nitro Compounds Aniline Miscellaneous Amines C2 to C6 Nitrogen Compounds Fluorobenzene Amines and Anilines