5-Fluoro-2-methylpyridine
- CAS No.
- 31181-53-0
- Chemical Name:
- 5-Fluoro-2-methylpyridine
- Synonyms
- 5-FLUORO-2-PICOLINE;3-FLUORO-6-PICOLINE;3-Fluoro-6-picoline 98%;5-FLUORO-2-METHYLPYRIDINE;3-FLUORO-6-METHYLPYRIDINE;2-methyl-5-fluoro-pyridine;Pyridine, 5-fluoro-2-methyl-;5-Fluoro-2-methylpyridine 98+%;5-Fluoro-2-methylpyridine, 97%;5-FLUORO-2-PICOLINE5-FLUORO-2-METHYLPYRIDINE
- CBNumber:
- CB8479536
- Molecular Formula:
- C6H6FN
- Molecular Weight:
- 111.12
- MDL Number:
- MFCD03095271
- MOL File:
- 31181-53-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 135-136 C |
|---|---|
| Density | 1.077g/ml |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| form | liquid |
| pka | 3.53±0.10(Predicted) |
| color | Clear, almost colourless |
| InChI | InChI=1S/C6H6FN/c1-5-2-3-6(7)4-8-5/h2-4H,1H3 |
| InChIKey | LXAHHHIGZXPRKQ-UHFFFAOYSA-N |
| SMILES | C1(C)=NC=C(F)C=C1 |
| CAS DataBase Reference | 31181-53-0(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H227-H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Hazard Codes | T,Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| HazardClass | IRRITANT |
| HS Code | 2933399990 |
5-Fluoro-2-methylpyridine price More Price(47)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | PC1509 | 5-Fluoro-2-methylpyridine 98% | 31181-53-0 | 1g | $37 | 2026-06-04 | Buy |
| Apolloscientific | PC1509 | 5-Fluoro-2-methylpyridine 98% | 31181-53-0 | 5g | $81 | 2026-06-04 | Buy |
| Activate Scientific | AS7195 | 5-Fluoro-2-methylpyridine 98% | 31181-53-0 | 1g | $33 | 2026-06-04 | Buy |
| Activate Scientific | AS7195 | 5-Fluoro-2-methylpyridine 98% | 31181-53-0 | 5g | $95 | 2026-06-04 | Buy |
| Activate Scientific | AS7195 | 5-Fluoro-2-methylpyridine 98% | 31181-53-0 | 25g | $371 | 2026-06-04 | Buy |
5-Fluoro-2-methylpyridine Chemical Properties, Uses, Production
Synthesis
5-Amino-2-methyl pyridine (2.8 g, 25.9 mmol) was added to a mixture of water (15 mL) and cone. HCl (7 mL) and cooled to 0°C. NaNO2 (3.5 g, 51.8 mmol) was added portion-wise with stirring over 10 min whilst keeping the reaction temperature between -5℃ and O℃. After stirring for 10 min 60 % w/w HPF6 (14 mL) was added dropwise with cooling, at which point a precipitate formed. This was filtered, washed with cold water and diethyl ether and dried. The solid was then heated slowly to 100℃; the reaction being very exothermic. After 5 min a dark red oily material formed which was then cooled to r.t. The oil was basifed with dilute sodium hydroxide to pH ~10 and extracted with dichloromethane. The combined organics were dried over sodium sulfate, filtered and evaporated in vacuo. The residue was purified by column chromatography over neutral alumina using 20 % dichloromethane-petroleum ether to yield 5-fluoro-2- methyl pyridine (1.57 g, 55%) as an oil.
References
[1] Patent: WO2008/62182, 2008, A1. Location in patent: Page/Page column 161
[2] Journal of Medicinal Chemistry, 1989, vol. 32, # 8, p. 1970 - 1977
[3] Patent: WO2003/87098, 2003, A1. Location in patent: Page/Page column 95-96
[4] Tetrahedron Letters, 2010, vol. 51, # 38, p. 5035 - 5037
[5] Patent: WO2018/15410, 2018, A1. Location in patent: Paragraph 0365-0368
5-Fluoro-2-methylpyridine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Beijing Ditai Pharmaceutical Technology Co., Ltd. | 010-13810111756 13810111756 | 1601345388@qq.com | China | 300 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Changzhou Huanling Chemical Co., Ltd. | 89803005 18206112582 | info@huanlingchem.com | China | 983 | 68 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16306 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Nan Jing Dirise Chemcial Co.,LTD | 025-52161033 15312098939 | 2432674894@qq.com | China | 585 | 64 |
View Latest Price from 5-Fluoro-2-methylpyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | 5-Fluoro-2-methylpyridine
31181-53-0
|
$1.10 | 1g | 99.00% | 100 Tons min | Dideu Industries Group Limited | |
 |
2020-01-03 | 5-Fluoro-2-methylpyridine
31181-53-0
|
$7.00 | 1KG | 99% | 100kg | Career Henan Chemical Co |
-
- 5-Fluoro-2-methylpyridine
31181-53-0
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 5-Fluoro-2-methylpyridine
31181-53-0
- $7.00
- 99%
- Career Henan Chemical Co
