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5-Methylsalicylamide

5-Methylsalicylamide Structure
5-Methylsalicylamide structure
CAS No.
39506-61-1
Chemical Name:
5-Methylsalicylamide
Synonyms
5-METHYLSALICYAMIDE;5-METHYL SALICYLAMIDE;5-Methyl salicylamide ,98%;8023 5-METHYL SALICYLAMIDE;2-HYDROXY-5-METHYLBENZAMIDE;Benzamide, 2-hydroxy-5-methyl-;Benzamide, 2-hydroxy-5-methyl- (9CI)
CBNumber:
CB8488002
Molecular Formula:
C8H9NO2
Molecular Weight:
151.16
MDL Number:
MFCD00017124
MOL File:
39506-61-1.mol
Last updated:2026-01-13 11:23:36
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5-Methylsalicylamide Properties

Melting point 182 °C
Boiling point 278.9±33.0 °C(Predicted)
Density 1.230±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
pka 8.67±0.18(Predicted)
color White to Off-White
CAS DataBase Reference 39506-61-1(CAS DataBase Reference)

5-Methylsalicylamide price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC TRC-M341178-500MG 5-Methylsalicylamide 39506-61-1 500mg $270 2026-06-03 Buy
TRC TRC-M341178-1G 5-Methylsalicylamide 39506-61-1 1g $402 2026-06-03 Buy
TRC TRC-M341178-100MG 5-Methylsalicylamide 39506-61-1 100mg $73 2026-06-03 Buy
Biosynth FH71075 2-Hydroxy-5-methylbenzamide 39506-61-1 0.025kg $162.25 2026-06-04 Buy
Biosynth FH71075 2-Hydroxy-5-methylbenzamide 39506-61-1 0.05kg $259.6 2026-06-04 Buy
Product number Packaging Price Buy
TRC-M341178-500MG 500mg $270 Buy
TRC-M341178-1G 1g $402 Buy
TRC-M341178-100MG 100mg $73 Buy
FH71075 0.025kg $162.25 Buy
FH71075 0.05kg $259.6 Buy

5-Methylsalicylamide Chemical Properties, Uses, Production

Synthesis

Methyl 5-methylsalicylate

22717-57-3

5-Methylsalicylamide

39506-61-1

General Steps: 1. 500 mg (3.01 mmol) of methyl 2-hydroxy-5-methylbenzoate was dissolved in 2 mL of dioxane and 2 mL of 28% aqueous ammonium hydroxide was added. The reaction mixture was heated at 80°C for 20 hours and subsequently concentrated to dryness by rotary evaporation. The resulting light brown solid was ground with ether to remove the unreacted ester to give 480 mg (2.89 mmol, 96% yield) of pure 2-hydroxy-5-methylbenzamide. 2. 26 mg (0.083 mmol) of N-[4,8-dimethoxyquinolin-2-yl]carbonyl]-4-piperidinone (prepared as described in Example 44), 12.5 mg (0.083 mmol) of 2-hydroxy-5-methylbenzamide, and 0.020 mL of morpholine were dissolved in 2 mL of methanol and the reaction was carried out at reflux for 20 hours. After completion of the reaction, the mixture was diluted with ethyl acetate, washed sequentially with water and brine, and the organic layer was dried over anhydrous sodium sulfate. After the solvent was removed by rotary evaporation, the crude product was purified by preparative thin layer chromatography (TLC) to afford 20 mg (0.045 mmol, 54% yield) of 1'-[4,8-dimethoxyquinolin-2-yl)carbonyl]-6-methylspiro[2H-1,3-benzoxazin-2,4'-piperidin]-4-(3H)-one (compound 137). Identification data of compound 137: 1H NMR (DMSO-d6): δ 2.28 (s, 3H), 3.95 (s, 3H), 4.06 (s, 3H), 6.98 (d, 1H), 7.19 (s, 1H), 7.23 (d, 1H), 7.33 (d, 1H), 7.52 (d, 1H), 7.56 (d, 1H), 7.68 (d, 1H), 8.77 (s, 1H). MS m/z: 448.1 (M + H)+, 470.0 (M + Na)+.

References

[1] Patent: US2010/9982, 2010, A1. Location in patent: Page/Page column 69-70
[2] Justus Liebigs Annalen der Chemie, 1924, vol. 439, p. 10

5-Methylsalicylamide Preparation Products And Raw materials

Raw materials

Toluene Acetyl chloride Triethylamine Tetrahydrofuran Dichloromethane
Thionyl chloride 5-Methylsalicylic acid Ammonia Methyl 5-methylsalicylate 1,4-Dioxane

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Preparation Products

5-Methylsalicylamide Suppliers

Global Suppliers ( 70)
Supplier Tel Email Country ProdList Advantage
Shanghai Synthfine Chemical Co.,Ltd 15921303235 sales@synthfine.com China 999 58
Shanghai Raise Chemical Technology Co.,Ltd 15026594951 rs@raise-chem.com China 4905 55
Quzhou Juhua Friendship Co., Ltd 0570-3066667 China 3922 58
Shanghai Na Qian Chemical Technology Co. Ltd. 13598610367 13598610367 2841375912@qq.com China 3575 52
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 025-66028182 17714375163 yftan@aikonchem.com China 16674 50
AN PharmaTech Co Ltd 86(21)68097365 sales@anpharma.net China 4875 55
Amadis Chemical Company Limited 571-89925085 sales@amadischem.com China 131885 58
Dalian lichuang Chemical Co., Ltd 0411-0411-00000000 13644282108 3500508746@qq.com China 2942 55
Zhengzhou Acme Chemical Co., Ltd. 037163312495 13303845143 1416159398@qq.com China 10151 58
Shanghai Jizhi Biochemical Technology Co. Ltd. 021-4009004166/18616739031 18616739031 3007523370@qq.com China 40000 58
Supplier Advantage
Shanghai Synthfine Chemical Co.,Ltd 58
Shanghai Raise Chemical Technology Co.,Ltd 55
Quzhou Juhua Friendship Co., Ltd 58
Shanghai Na Qian Chemical Technology Co. Ltd. 52
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 50
AN PharmaTech Co Ltd 55
Amadis Chemical Company Limited 58
Dalian lichuang Chemical Co., Ltd 55
Zhengzhou Acme Chemical Co., Ltd. 58
Shanghai Jizhi Biochemical Technology Co. Ltd. 58

5-Methylsalicylamide Spectrum

5-Methylsalicylamide(39506-61-1)1HNMR

39506-61-1 (5-Methylsalicylamide) Related Search:

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5-Acetylsalicylamide 5-[2-[[3-(1,3-benzodioxol-5-yl)-1-methylpropyl]amino]-1-hydroxyethyl]salicylamide 5-Bromoacetyl salicylamide 3-carbamyl-(3'-picolyl)-4-methoxy-1-benzamide 2-Hydroxy-5-methylbenzhydrazide
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5-METHYL SALICYLAMIDE 5-METHYLSALICYAMIDE Benzamide, 2-hydroxy-5-methyl- (9CI) 8023 5-METHYL SALICYLAMIDE 5-Methyl salicylamide ,98% 2-HYDROXY-5-METHYLBENZAMIDE Benzamide, 2-hydroxy-5-methyl- 39506-61-1 AMIDE Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts