| Company Name: |
Energy Chemical |
| Tel: |
400-0056266 |
| Email: |
sales8178@energy-chemical.com |
| Company Name: |
LGM Pharma |
| Tel: |
1-(800)-881-8210 |
| Email: |
inquiries@lgmpharma.com |
- Desvenlafaxine
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- $73.00
-
2026-07-27
- CAS:93413-62-8
- Purity: 99.81%
- Supply Ability: 10g
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| | O-Desmethylvenlafaxine Basic information |
| | O-Desmethylvenlafaxine Chemical Properties |
| Melting point | 208-213°C | | Boiling point | 403.8±25.0 °C(Predicted) | | density | 1.115±0.06 g/cm3(Predicted) | | Fp | 9℃ | | storage temp. | 2-8°C | | solubility | insoluble in EtOH; ≥13.2 mg/mL in DMSO; ≥2.45 mg/mL in EtOH | | pka | 10.04±0.26(Predicted) | | form | Solid | | color | White to off-white | | Major Application | clinical testing | | InChI | 1S/C16H25NO2/c1-17(2)12-15(13-6-8-14(18)9-7-13)16(19)10-4-3-5-11-16/h6-9,15,18-19H,3-5,10-12H2,1-2H3 | | InChIKey | KYYIDSXMWOZKMP-UHFFFAOYSA-N | | SMILES | N(CC(C2(CCCCC2)O)c1ccc(cc1)O)(C)C | | LogP | 0.33 at 25℃ and pH6 |
| | O-Desmethylvenlafaxine Usage And Synthesis |
| Description | Desvenlafaxine is a new member of the SNRI class of antidepressants.
It is marketed as an extended release tablet for once-daily oral treatment
of MDD in adult patients. Desvenlafaxine (O-desmethylvenlafaxine) is
the major active metabolite of the previously marketed antidepressant
venlafaxine (Effexor). Similar to venlafaxine, desvenlafaxine is a more
potent inhibitor of serotonin and norepinephrine reuptake (IC50＝47 and
531 nM, respectively) than that of dopamine (62% inhibition at 100 mM)
in in vitro studies. It does not have significant in vitro affinity for other
neurotransmitter reporters such as a1-adrenergic, H1-histaminergic,
or muscarine-cholinergic receptors. Desvenlafaxine is marketed as a
racemic mixture. Specific pharmacological properties of the enantiomers
of desvenlafaxine have not been reported. | | Chemical Properties | White Solid | | Originator | Wyeth (United States) | | Uses | A metabolite of Venlafaxine, a selective serotonin noradrenaline reuptake inhibitor. Used as an antidepressant | | Uses | A metabolite of Venlafaxine (V120000), a selective serotonin noradrenaline reuptake inhibitor (SNRI). Used as an antidepressant. | | Uses | a metabolite of Venlafaxine .;Labeled Venlafaxine, intended for use as an internal standard for the quantification of Venlafaxine by GC- or LC-mass spectrometry. | | Definition | ChEBI: A tertiary amino compound that is N,N-dimethylethanamine substituted at position 1 by a 1-hydroxycyclohexyl and 4-hydroxyphenyl group. It is a metabolite of the drug venlafaxine. | | Brand name | Pristiq | | General Description | An analytical reference standard applicable for use as starting material in calibrators or controls for a variety of LC/MS or GC/MS applications such as urine drug testing, forensic analysis, or clinical toxicology. Also known as desvenlafaxine, O-desmethylvenlafaxine is an SNRI antidepressant marketed under the trade name Pristiq for the treatment of depression. O-desmethylvenlafaxine is also a major urinary metabolite of venlafaxine, an SNRI antidepressant sold as Effexor or Efexor and used to treat major depressive disorder, generalized anxiety disorder, and other anxiety disorders associated with depression. | | Synthesis | Desvenlafaxine is chemically derived from 4-benzyloxyphenylacetic acid, by first converting to the acid chloride with oxalyl chloride and then condensing with dimethylamine to produce the corresponding N,N-dimethyl amide. Deprotonation of the amide with butyllithium, followed by condensation with cyclohexanone gives a b-hydroxyamide intermediate, which is reduced with alane, and debenzylated by using palladium on carbon and 1,4-cyclohexadiene to produce desvenlafaxine. |
| | O-Desmethylvenlafaxine Preparation Products And Raw materials |
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