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5'-Isobutylthio-5'-deoxyadenosine

5'-Isobutylthio-5'-deoxyadenosine Structure
5'-Isobutylthio-5'-deoxyadenosine structure
CAS No.
35899-54-8
Chemical Name:
5'-Isobutylthio-5'-deoxyadenosine
Synonyms
SIBA;SIBA, 10 mM in DMSO;5'-Isobutylthioadenosine;5'-S-Isobutylthioadenosine;5'-S-Isobutyl-5'-deoxyadenosine;5''-Deoxy-5''-S-isobutyladenosine;5'-Deoxy-5'-isobutylthioadenosine;5'-Isobutylthio-5'-deoxyadenosine;5'-Isobutylthio-5'-deoxyadenosine;5’-deoxy-5’-s-isobutylthioadenosine
CBNumber:
CB8503653
Molecular Formula:
C14H21N5O3S
Molecular Weight:
339.41
MDL Number:
MFCD00056008
MOL File:
35899-54-8.mol
MSDS File:
SDS
Last updated:2026-09-12 18:55:46
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5'-Isobutylthio-5'-deoxyadenosine Properties

Boiling point 631.2±65.0 °C(Predicted)
Density 1.63±0.1 g/cm3(Predicted)
storage temp. Keep in dark place,Inert atmosphere,2-8°C
solubility DMSO : ≥ 100 mg/mL (294.63 mM)
pka 13.13±0.70(Predicted)
form Solid
color Off-white to gray

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
WGK Germany  3

5'-Isobutylthio-5'-deoxyadenosine price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 38758 SIBA ≥98% 35899-54-8 10mg $40 2026-04-30 Buy
Cayman Chemical 38758 SIBA ≥98% 35899-54-8 50mg $139 2026-04-30 Buy
Cayman Chemical 38758 SIBA ≥98% 35899-54-8 100mg $237 2026-04-30 Buy
ChemScene CS-5062 SIBA 99.64% 35899-54-8 5mg $211 2026-06-04 Buy
ChemScene CS-5062 SIBA 99.64% 35899-54-8 10mg $276 2026-06-04 Buy
Product number Packaging Price Buy
38758 10mg $40 Buy
38758 50mg $139 Buy
38758 100mg $237 Buy
CS-5062 5mg $211 Buy
CS-5062 10mg $276 Buy

5'-Isobutylthio-5'-deoxyadenosine Chemical Properties, Uses, Production

Uses

SIBA (5'-Isobutylthioadenosine) is a transmethylation inhibitor (SAH (HY-19528) analogue), with potent anti-proliferative activity. SIBA reversibly inhibits the production of HSV-1 by blocking methylation, specifically by blocking the 5' end-capping of viral mRNA. SIBA also inhibits the growth of tumour cells in vitro and metastatic spread in vivo. SIBA can be used in cancer, HSV-1 infection and anti-malaria studies[1][2][3].

in vivo

SIBA (150 mg/kg; i.p.; twice weekly for 3 weeks) inhibits tumor growth in vivo[1].
SIBA (15 mg/kg; i.p.; thrice weekly for 4 weeks) inhibits metastatic spread of RMS-J1 cells in vivo[1].

Animal Model:C57BL/6 female mice (4-8 weeks old)[1].
Dosage:150 mg/kg
Administration:Intraperitoneal injection; twice weekly for 3 weeks.
Result:Significantly reduced the median number of lung metastases.
Animal Model:Adult syngeneic Wistar AG rats (8-week-old; subcutaneously grafted with RMS-J1 cells)[1].
Dosage:15 mg/kg
Administration:Intraperitoneal injection; thrice weekly for 4 weeks.
Result:Inhibited in vivo metastatic spread of RMS-J1 cells, and showed median numbers of lung metastatic nodules was 26.

IC 50

Plasmodium; HSV-1

References

[1] F Breillout , et al. Association of SIBA treatment and a Met-depleted diet inhibits in vitro growth and in vivo metastatic spread of experimental tumor cell lines. Clin Exp Metastasis. Jan-Feb 1988;6(1):3-16. DOI:10.1007/BF01580402
[2] B Jacquemont, et al. Inhibition of viral RNA methylation in herpes simplex virus type 1-infected cells by 5' S-isobutyl-adenosine. J Virol. 1977 Apr;22(1):160-7. DOI:10.1128/JVI.22.1.160-167.1977
[3] Lawrence F, et al. Effect of 5'-deoxy-5'-isobutylthioadenosine on putrescine uptake and polyamine biosynthesis by chick embryo fibroblasts. Biochem J. 1982 Jun 15;204(3):853-9. DOI:10.1042/bj2040853

5'-Isobutylthio-5'-deoxyadenosine Preparation Products And Raw materials

Raw materials

Preparation Products

5'-Isobutylthio-5'-deoxyadenosine Suppliers

Global Suppliers ( 43)
Supplier Tel Email Country ProdList Advantage
Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 7545 61
Shanghai Beckham Medical Technology Co., Ltd 13816613772 huahero21@sina.com China 2994 55
Guangzhou QiYun Biotechnology Co., Ltd. 020-61288194 61288195 505721671@qq.com China 3853 58
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
Musechem +1-800-259-7612 info@musechem.com United States 4648 60
Alfa Chemistry +1-5166625404; Info@alfa-chemistry.com United States 20000 58
BOC Sciences 16314854226; +8616314854226 inquiry@bocsci.com United States 19852 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
NewCan Biotech Limited +86-571-86912261 19975279805 sales@newcanbio.com China 9984 58
BOC Sciences 16314854226 inquiry@bocsci.com United States 9713 58
Supplier Advantage
Haoyuan Chemexpress Co., Ltd. 61
Shanghai Beckham Medical Technology Co., Ltd 55
Guangzhou QiYun Biotechnology Co., Ltd. 58
Shanghai YuanYe Biotechnology Co., Ltd. 60
Musechem 60
Alfa Chemistry 58
BOC Sciences 58
TargetMol Chemicals Inc. 58
NewCan Biotech Limited 58
BOC Sciences 58

View Latest Price from 5'-Isobutylthio-5'-deoxyadenosine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
SIBA pictures 2026-05-11 SIBA
35899-54-8
 $44.00-119.00 99.48% 10g TargetMol Chemicals Inc.
SIBA pictures 2026-05-11 SIBA
35899-54-8
 $44.00-119.00 99.48% 10g TargetMol Chemicals Inc.
  • SIBA pictures
  • SIBA
    35899-54-8
  • $44.00-119.00
  • 99.48%
  • TargetMol Chemicals Inc.
  • SIBA pictures
  • SIBA
    35899-54-8
  • $44.00-119.00
  • 99.48%
  • TargetMol Chemicals Inc.

5'-Isobutylthio-5'-deoxyadenosine Spectrum

5'-ISOBUTYLTHIO-5'-DEOXYADENOSINE(35899-54-8)1HNMR

35899-54-8 (5'-Isobutylthio-5'-deoxyadenosine) Related Search:

Dideoxyinosine 2'-Deoxyadenosine monohydrate Cyclic AMP Dideoxyadenosine 5'-DEOXYADENOSINE
ADP Adenosine 5'-Isobutylthio-5'-deoxyadenosine (S)-1-Mercaptoglycerol Ethyl isobutyl sulfide
iso-Butyl propyl sulfide 2-(Isobutylthio)ethanol 3-Ethylthio-1,2-propanediol,97% DL-Buthionine-[s,r]-sulfoximine 5'-Deoxy-5'-methylthioadenosine

1of3

5'-Isobutylthioadenosine 5'-ISOBUTYLTHIOADENOSINE;5'-DEOXY-5'-ISOBUTYLTHIOADENOSINE 5'-Deoxy-5'-isobutylthioadenosine 5’-deoxy-5’-s-isobutylthioadenosine 5'-S-(2-Methylpropyl)-5'-thioadenosine SIBA 5'-S-Isobutyl-5'-deoxyadenosine 5'-S-Isobutylthioadenosine Adenosine, 5'-S-(2-methylpropyl)-5'-thio- 5''-Deoxy-5''-S-isobutyladenosine 5μ-Deoxy-5μ-S-isobutylthioadenosine, 5μ-S-(2-Methylpropyl)-5μ-thioadenosine chick embryo fibroblasts,Parasite,inhibit,HEp2,3 LL,malaria,HSV,Inhibitor,SAH,HSV-1,Herpes simplex virus,cancer,RMS-J1,SIBA,Nucleoside Antimetabolite/Analog (2R,3R,4S,5S)-2-(6-Amino-9H-purin-9-yl)-5-((isobutylthio)methyl)tetrahydrofuran-3,4-diol 5'-Isobutylthio-5'-deoxyadenosine SIBA, 10 mM in DMSO 5'-Isobutylthio-5'-deoxyadenosine 35899-54-8