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1-N-CBZ-3-METHYL PIPERAZINE

1-N-CBZ-3-METHYL PIPERAZINE Structure
1-N-CBZ-3-METHYL PIPERAZINE structure
CAS No.
84477-85-0
Chemical Name:
1-N-CBZ-3-METHYL PIPERAZINE
Synonyms
CHEMPACIFIC 38150;1-Cbz-3-methylpiperazine;4-Cbz-2-methylpiperazine;4-N-CBZ-2-METHYL PIPERAZINE;1-N-CBZ-3-METHYL PIPERAZINE;N-1-CBZ-3-METHYL-PIPERAZINE;(R)-1-CBZ-2-METHYL-PIPERAZINE;4-N-CBZ-2-Methylpiperazine-HCl;(R)-1-N-CBZ-2-METHYL-PIPERAZINE;4-BENZOXYCARBONYL-2-METHYLPIPERAZINE
CBNumber:
CB8696175
Molecular Formula:
C13H18N2O2
Molecular Weight:
234.29
MDL Number:
MFCD07367776
MOL File:
84477-85-0.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 05:07:40
Product description Number Pack Size Price
(R)-2-Methylpiperazine-1-carboxylic acid benzyl ester Asreported 284587 500mg $375
(R)-2-Methylpiperazine-1-carboxylic acid benzyl ester Asreported 284587 1g $635
(R)-2-Methylpiperazine-1-carboxylic acid benzyl ester Asreported 284587 2g $895
(R)-2-Methylpiperazine-1-carboxylic acid benzyl ester Asreported 284587 5g $1270
(R)-2-Methylpiperazine-1-carboxylic acid benzyl ester ≥98% 17313 250MG $89.13
Request For Quotation

1-N-CBZ-3-METHYL PIPERAZINE Properties

Boiling point 358.0±30.0 °C(Predicted)
Density 1.105±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
pka 8.50±0.40(Predicted)
Appearance Colorless to light yellow Liquid

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

1-N-CBZ-3-METHYL PIPERAZINE price More Price(48)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Usbiological 284587 (R)-2-Methylpiperazine-1-carboxylic acid benzyl ester Asreported 84477-85-0 500mg $375 2026-06-03 Buy
Usbiological 284587 (R)-2-Methylpiperazine-1-carboxylic acid benzyl ester Asreported 84477-85-0 1g $635 2026-06-03 Buy
Usbiological 284587 (R)-2-Methylpiperazine-1-carboxylic acid benzyl ester Asreported 84477-85-0 2g $895 2026-06-03 Buy
Usbiological 284587 (R)-2-Methylpiperazine-1-carboxylic acid benzyl ester Asreported 84477-85-0 5g $1270 2026-06-03 Buy
Chem-Impex 17313 (R)-2-Methylpiperazine-1-carboxylic acid benzyl ester ≥98% 84477-85-0 250MG $89.13 2026-05-19 Buy
Product number Packaging Price Buy
284587 500mg $375 Buy
284587 1g $635 Buy
284587 2g $895 Buy
284587 5g $1270 Buy
17313 250MG $89.13 Buy

1-N-CBZ-3-METHYL PIPERAZINE Chemical Properties,Uses,Production

Synthesis

2-Methylpiperazine

109-07-9

Benzyl chloroformate

501-53-1

1-N-CBZ-3-METHYL PIPERAZINE

84477-85-0

Example 1: 5.00 g (0.0499 mol) of racemic 2-methylpiperazine was added to a 100 mL four-necked flask and dissolved in 44 g of 1-butanol (0.05 wt% in water). The solution was cooled to 0°C and 8.47 g of benzyl chloroformate (0.0489 mol, 98.5% purity as determined by HPLC, equivalent to 0.98 equivalents) was added slowly dropwise over a temperature range of 0 to 8°C. After the dropwise addition, the reaction mixture was stirred at 0 to 5 °C for 2 hours. During this time, a sample was taken and analyzed by HPLC using the internal standard method (internal standard: anisole), and the yield of 1-Benzyloxycarbonyl-3-methylpiperazine was measured to be 83.9% (based on 2-methylpiperazine). Subsequently, the reaction mixture was continued to be stirred at room temperature for 12 hours and analyzed again and the yield was increased to 85.1%. Example 3: The reaction conditions were the same as in Example 1 , with the difference that the amount of benzyl chloroformate was increased to 10.1 g (0.0597 mol, 1.17 eq.). After 2 hours of reaction at 0 to 5 °C, HPLC analysis showed 93.8% yield of 1 -benzyloxycarbonyl-3-methylpiperazine (based on 2-methylpiperazine). The yield was further increased to 95.1% after continued stirring at room temperature for 12 hours.

References

[1] Patent: EP1548010, 2005, A1. Location in patent: Page/Page column 16; 17
[2] Patent: EP1548010, 2005, A1. Location in patent: Page/Page column 18
[3] Patent: EP1548010, 2005, A1. Location in patent: Page/Page column 19
[4] Synthetic Communications, 2007, vol. 37, # 20, p. 3623 - 3634
[5] Patent: EP3124482, 2017, A1. Location in patent: Paragraph 0476; 0477

1-N-CBZ-3-METHYL PIPERAZINE Preparation Products And Raw materials

Raw materials

2-Methylpiperazine Benzyl chloroformate

Preparation Products

1-N-CBZ-3-METHYL PIPERAZINE Suppliers

Global( 66)Suppliers
Supplier Tel Email Country ProdList Advantage
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49979 58
SIMAGCHEM CORP 		+86-5922680277 +86-13806087780 sale@simagchem.com China 17346 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 20582 58
Dayang Chem (Hangzhou) Co.,Ltd. 		+86-0571-88938639 +8617705817739 info@dycnchem.com China 52705 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418684 +8618949823763 sales@tnjchem.com China 25356 58
PT CHEM GROUP LIMITED 		+86-85511178; peter68@ptchemgroup.com China 35425 58
Aladdin Scientific 		tp@aladdinsci.com United States 52923 58
Suzhou ARTK Medchem Co., Ltd. 		+8618118463618 sales1@artkmedchem.com China 39021 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131957 58
Supplier Advantage
Alchem Pharmtech,Inc. 		58
CONIER CHEM AND PHARMA LIMITED 		58
SIMAGCHEM CORP 		58
Dideu Industries Group Limited 		58
Dayang Chem (Hangzhou) Co.,Ltd. 		58
Hefei TNJ Chemical Industry Co.,Ltd. 		58
PT CHEM GROUP LIMITED 		58
Aladdin Scientific 		58
Suzhou ARTK Medchem Co., Ltd. 		58
Amadis Chemical Company Limited 		58

View Lastest Price from 1-N-CBZ-3-METHYL PIPERAZINE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1-N-CBZ-3-METHYL PIPERAZINE pictures 2025-11-18 1-N-CBZ-3-METHYL PIPERAZINE
84477-85-0
 $1.10 1g 99.00% 100 Tons Dideu Industries Group Limited

1-N-CBZ-3-METHYL PIPERAZINE Spectrum

1-N-CBZ-3-METHYL PIPERAZINE(84477-85-0)1HNMR

84477-85-0(1-N-CBZ-3-METHYL PIPERAZINE)Related Search:

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4-Cbz-piperazine-2-carboxylate methyl ester N-1-BOC-N-4-CBZ-2-PIPERAZINE CARBOXYLIC ACID (R)-2-METHYL-PIPERAZINE-1,4-DICARBOXYLIC ACID 4-BENZYL ESTER 1-TERT-BUTYL ESTER 1-N-CBZ-2-METHYL PIPERAZINE,N-1-CBZ-2-METHYL-PIPERAZINE 1-CBZ-(R)-3-METHYLPIPERAZINE
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TERT-BUTYL-4-CBZ-PIPERAZINE-2-CARBOXYLATE 2,5-DIAZA-BICYCLO[2.2.2]OCTANE-2-CARBOXYLIC ACID BENZYL ESTER 4-METHYL-3-PYRROLIDIN-1-YLMETHYL-PIPERAZINE-1-CARBOXYLIC ACID BENZYL ESTER

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CHEMPACIFIC 38150 1-N-CBZ-3-METHYL PIPERAZINE (R)-1-CBZ-2-METHYL-PIPERAZINE (R)-1-N-CBZ-2-METHYL-PIPERAZINE (R)-2-METHYL-PIPERAZINE-1-CARBOXYLIC ACID BENZYL ESTER (R)-BENZYL 2-METHYLPIPERAZINE-1-CARBOXYLATE (R)-3-METHYL-PIPERAZINE-1-CARBOXYLIC ACID BENZYL ESTER HYDROCHLORIDE 4-BENZOXYCARBONYL-2-METHYLPIPERAZINE 1-Cbz-3-methylpiperazine 4-N-CBZ-2-METHYL PIPERAZINE REF DUPL: (R)-1-N-Cbz-2-methyl-piperazine 1-Piperazinecarboxylic acid, 3-methyl-, phenylmethyl ester benzyl 3-methylpiperazine-1-carboxylate 4-N-CBZ-2-Methylpiperazine-HCl N-1-CBZ-3-METHYL-PIPERAZINE 1-N-CBZ-3-METHYL PIPERAZINE ISO 9001：2015 REACH 4-Cbz-2-methylpiperazine 84477-85-0