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1-N-Cbz-3-methyl piperazine

1-N-Cbz-3-methyl piperazine Structure
1-N-Cbz-3-methyl piperazine structure
CAS No.
84477-85-0
Chemical Name:
1-N-Cbz-3-methyl piperazine
Synonyms
CHEMPACIFIC 38150;1-Cbz-3-methylpiperazine;4-Cbz-2-methylpiperazine;4-N-CBZ-2-METHYL PIPERAZINE;N-1-CBZ-3-METHYL-PIPERAZINE;1-N-Cbz-3-methyl piperazine;(R)-1-CBZ-2-METHYL-PIPERAZINE;4-N-CBZ-2-Methylpiperazine-HCl;(R)-1-N-CBZ-2-METHYL-PIPERAZINE;4-BENZOXYCARBONYL-2-METHYLPIPERAZINE
CBNumber:
CB8696175
Molecular Formula:
C13H18N2O2
Molecular Weight:
234.29
MDL Number:
MFCD07367776
MOL File:
84477-85-0.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:55:51
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1-N-Cbz-3-methyl piperazine Properties

Boiling point 358.0±30.0 °C(Predicted)
Density 1.105±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
pka 8.50±0.40(Predicted)
Appearance Colorless to light yellow Liquid

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

1-N-Cbz-3-methyl piperazine price More Price(36)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Usbiological 284587 (R)-2-Methylpiperazine-1-carboxylic acid benzyl ester Asreported 84477-85-0 500mg $375 2026-06-03 Buy
Usbiological 284587 (R)-2-Methylpiperazine-1-carboxylic acid benzyl ester Asreported 84477-85-0 1g $635 2026-06-03 Buy
Usbiological 284587 (R)-2-Methylpiperazine-1-carboxylic acid benzyl ester Asreported 84477-85-0 2g $895 2026-06-03 Buy
Usbiological 284587 (R)-2-Methylpiperazine-1-carboxylic acid benzyl ester Asreported 84477-85-0 5g $1270 2026-06-03 Buy
Chem-Impex 17313 (R)-2-Methylpiperazine-1-carboxylic acid benzyl ester ≥98% 84477-85-0 250MG $89.13 2026-05-19 Buy
Product number Packaging Price Buy
284587 500mg $375 Buy
284587 1g $635 Buy
284587 2g $895 Buy
284587 5g $1270 Buy
17313 250MG $89.13 Buy

1-N-Cbz-3-methyl piperazine Chemical Properties, Uses, Production

Synthesis

2-Methylpiperazine

109-07-9

Benzyl chloroformate

501-53-1

1-N-CBZ-3-METHYL PIPERAZINE

84477-85-0

Example 1: 5.00 g (0.0499 mol) of racemic 2-methylpiperazine was added to a 100 mL four-necked flask and dissolved in 44 g of 1-butanol (0.05 wt% in water). The solution was cooled to 0°C and 8.47 g of benzyl chloroformate (0.0489 mol, 98.5% purity as determined by HPLC, equivalent to 0.98 equivalents) was added slowly dropwise over a temperature range of 0 to 8°C. After the dropwise addition, the reaction mixture was stirred at 0 to 5 °C for 2 hours. During this time, a sample was taken and analyzed by HPLC using the internal standard method (internal standard: anisole), and the yield of 1-Benzyloxycarbonyl-3-methylpiperazine was measured to be 83.9% (based on 2-methylpiperazine). Subsequently, the reaction mixture was continued to be stirred at room temperature for 12 hours and analyzed again and the yield was increased to 85.1%. Example 3: The reaction conditions were the same as in Example 1 , with the difference that the amount of benzyl chloroformate was increased to 10.1 g (0.0597 mol, 1.17 eq.). After 2 hours of reaction at 0 to 5 °C, HPLC analysis showed 93.8% yield of 1 -benzyloxycarbonyl-3-methylpiperazine (based on 2-methylpiperazine). The yield was further increased to 95.1% after continued stirring at room temperature for 12 hours.

References

[1] Patent: EP1548010, 2005, A1. Location in patent: Page/Page column 16; 17
[2] Patent: EP1548010, 2005, A1. Location in patent: Page/Page column 18
[3] Patent: EP1548010, 2005, A1. Location in patent: Page/Page column 19
[4] Synthetic Communications, 2007, vol. 37, # 20, p. 3623 - 3634
[5] Patent: EP3124482, 2017, A1. Location in patent: Paragraph 0476; 0477

1-N-Cbz-3-methyl piperazine Preparation Products And Raw materials

Raw materials

2-Methylpiperazine Benzyl chloroformate

Preparation Products

1-N-Cbz-3-methyl piperazine Suppliers

Global Suppliers ( 66)
Supplier Tel Email Country ProdList Advantage
ForeChem (Nantong) Technology Co.,Ltd. 513-85982855 18921614129 sales@xianxingpharm.com China 2712 61
Sichuan Guanghan Bio-Tech Co., Ltd +86-28-86127071 info@sino-produce.com China 400 66
Shanghai Boc Chemical Co.,Ltd 021-34975603-808 18721111801 sales@bocpharma.com China 991 64
T&W GROUP 021-61551611 13296011611 contact@trustwe.com China 9884 58
Acesys Pharmatech 18860950986 tangmanman@zenjipharma.com China 1731 55
Huainan Kedi Chemical Factory 0554-2106669 sales1@kedichem.com China 4914 55
Porse Fine Chemical Co.,LTD 20-66003216 18666003216 info@porsefinechemical.com China 1963 62
Chengdu HuaXia Chemical Reagent Co. Ltd 400-1166-196 13458535857 cdhxsj@163.com China 13323 58
Shanghai GaoDao Pharmaceutical Co., Ltd. 021-15001867143 15001867143 1095570358@qq.com China 914 55
SanoChem (Chengdu) Tech. Co., Ltd. 28-87999436 02887999436 sales@sano-chem.com China 3792 55
Supplier Advantage
ForeChem (Nantong) Technology Co.,Ltd. 61
Sichuan Guanghan Bio-Tech Co., Ltd 66
Shanghai Boc Chemical Co.,Ltd 64
T&W GROUP 58
Acesys Pharmatech 55
Huainan Kedi Chemical Factory 55
Porse Fine Chemical Co.,LTD 62
Chengdu HuaXia Chemical Reagent Co. Ltd 58
Shanghai GaoDao Pharmaceutical Co., Ltd. 55
SanoChem (Chengdu) Tech. Co., Ltd. 55

View Latest Price from 1-N-Cbz-3-methyl piperazine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1-N-CBZ-3-METHYL PIPERAZINE pictures 2026-08-20 1-N-CBZ-3-METHYL PIPERAZINE
84477-85-0
 $1.10 1g 99.00% 100 Tons Dideu Industries Group Limited

1-N-Cbz-3-methyl piperazine Spectrum

1-N-CBZ-3-METHYL PIPERAZINE(84477-85-0)1HNMR

84477-85-0 (1-N-Cbz-3-methyl piperazine) Related Search:

1-N-Cbz-3-methyl piperazine (S)-N-4-Boc-N-1-Cbz-2-piperazine carboxylic acid (R)-N-1-Boc-N-4-Cbz-2-piperazine carboxylic acid 1-N-CBZ-2-METHYL PIPERAZINE,N-1-CBZ-2-METHYL-PIPERAZINE 4-Cbz-piperazine-2-carboxylate methyl ester
(S)-N-1-Boc-N-4-Cbz-2-piperazine carboxylic acid (R)-2-Methyl-piperazine-1,4-dicarboxylic acid 4-benzyl ester 1-tert-butyl ester 1-Cbz-(R)-3-methylpiperazine 1-Cbz-(S)-3-methylpiperazine N-1-Boc-N-4-Cbz-2-piperazine carboxylic acid
2-Cbz-2,5-diazabicyclo[2.2.1]heptane (R)-Piperazine-1,3-dicarboxylic acid 1-benzyl ester tert-Butyl-4-Cbz-piperazine-2-carboxylate (R)-4-N-Cbz-piperazine-2-carboxylic acid methyl ester 4-Methyl-3-pyrrolidin-1-ylmethyl-piperazine-1-carboxylic acid benzyl ester
2-(S)-Methylpiperazine-1,4-dicarboxylic acid 4-benzyl ester 1-ter-butyl ester 4-N-Cbz-2-hydroxymethyl-piperazine 2,5-Diaza-bicyclo[2.2.2]octane-2-carboxylic acid benzyl ester

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CHEMPACIFIC 38150 (R)-1-CBZ-2-METHYL-PIPERAZINE (R)-1-N-CBZ-2-METHYL-PIPERAZINE (R)-2-METHYL-PIPERAZINE-1-CARBOXYLIC ACID BENZYL ESTER (R)-BENZYL 2-METHYLPIPERAZINE-1-CARBOXYLATE (R)-3-METHYL-PIPERAZINE-1-CARBOXYLIC ACID BENZYL ESTER HYDROCHLORIDE 4-BENZOXYCARBONYL-2-METHYLPIPERAZINE 1-Cbz-3-methylpiperazine 4-N-CBZ-2-METHYL PIPERAZINE REF DUPL: (R)-1-N-Cbz-2-methyl-piperazine 1-Piperazinecarboxylic acid, 3-methyl-, phenylmethyl ester benzyl 3-methylpiperazine-1-carboxylate 4-N-CBZ-2-Methylpiperazine-HCl N-1-CBZ-3-METHYL-PIPERAZINE 1-N-CBZ-3-METHYL PIPERAZINE ISO 9001：2015 REACH 4-Cbz-2-methylpiperazine 1-N-Cbz-3-methyl piperazine 84477-85-0