1-N-Cbz-2-Methylpiperazine
- CAS No.
- 444666-46-0
- Chemical Name:
- 1-N-Cbz-2-Methylpiperazine
- Synonyms
- 1-CBZ-2-METHYLPIPERAZINE;1-N-CBZ-2-METHYL PIPERAZINE;N-1-CBZ-2-METHYL-PIPERAZINE;2-Methylpiperazine, N1-CBZ protected 96%;2-METHYL-PIPERAZINE-1-CARBOXYLIC ACID BENZYL ESTER;1-N-Cbz-2-Methylpiperazine N-1-Cbz-2-Methylpiperazine;2-Methyl-1-piperazinecarboxylic acid phenylmethyl ester;1-Piperazinecarboxylic acid, 2-methyl-, phenylmethyl ester
- CBNumber:
- CB7216486
- Molecular Formula:
- C13H18N2O2
- Molecular Weight:
- 234.29
- MDL Number:
- MFCD04115058
- MOL File:
- 444666-46-0.mol
- MSDS File:
- SDS
1-N-Cbz-2-Methylpiperazine price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR16019 | 2-Methylpiperazine, N1-CBZ protected 95% | 444666-46-0 | 1g | $245 | 2026-06-04 | Buy |
| Matrix Scientific | 208947 | 2-Methylpiperazine-1-carboxylic acid benzyl ester | 444666-46-0 | 1.00g | $250 | 2026-05-18 | Buy |
| Matrix Scientific | 208947 | 2-Methylpiperazine-1-carboxylic acid benzyl ester | 444666-46-0 | 5.00g | $1021 | 2026-05-18 | Buy |
| aablocks | AA00D8PO | Benzyl 2-methylpiperazine-1-carboxylate 98% | 444666-46-0 | 1g | $63 | 2026-05-28 | Buy |
| aablocks | AA00D8PO | Benzyl 2-methylpiperazine-1-carboxylate 98% | 444666-46-0 | 5g | $174 | 2026-05-28 | Buy |
1-N-Cbz-2-Methylpiperazine Chemical Properties, Uses, Production
Synthesis
109-07-9
501-53-1
444666-46-0
The general procedure for synthesizing 1-N-Cbz-2-methylpiperazine from 2-methylpiperazine and benzyl chloroformate is as follows: referring to Example 5, 10.02 g (0.100 mol) of racemic 2-methylpiperazine was added to a 200 mL four-necked flask equipped with a pH meter and a dropping funnel, followed by the addition of 80.2 g of 1 -butanol to solubilize it, and then the addition of 20.1 g of water (water content of 20.0 wt%). Benzyl chloroformate was slowly added dropwise under vigorous stirring. At the same time, the pH of the reaction system was maintained between 7.5 and 8.5 by dropwise addition of 48 wt% aqueous sodium hydroxide. If necessary, an ice bath was used for cooling to maintain the internal temperature at 23 to 26°C (final water content of 23.0 wt%). After completion of the dropwise addition, the reaction was continued under vigorous stirring for 2 hours. A sample of the reaction solution was analyzed and showed a 50.4% yield of 1-benzyloxycarbonyl-2-methylpiperazine.
References
[1] Patent: EP1548010, 2005, A1. Location in patent: Page/Page column 18
1-N-Cbz-2-Methylpiperazine Preparation Products And Raw materials
Raw materials
Preparation Products
1-N-Cbz-2-Methylpiperazine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ForeChem (Nantong) Technology Co.,Ltd. | 513-85982855 18921614129 | sales@xianxingpharm.com | China | 2712 | 61 |
| Sichuan Guanghan Bio-Tech Co., Ltd | +86-28-86127071 | info@sino-produce.com | China | 400 | 66 |
| Shanghai Boc Chemical Co.,Ltd | 021-34975603-808 18721111801 | sales@bocpharma.com | China | 991 | 64 |
| China DongFan Chemical Co.,LTD | 86-0571-85151182 | China | 5681 | 66 | |
| Chengdu HappySyn Pharmaceutical Technology Co., Ltd. | 85114309 18982182443 | yangli@happysyn.com | China | 2284 | 55 |
| Shanghai Carlow Chemicals Co., Ltd. | 21-33526724 18930996265 | info@carlowchem.com | China | 1996 | 58 |
| Porse Fine Chemical Co.,LTD | 20-66003216 18666003216 | info@porsefinechemical.com | China | 1963 | 62 |
| Chengdu HuaXia Chemical Reagent Co. Ltd | 400-1166-196 13458535857 | cdhxsj@163.com | China | 13323 | 58 |
| Hangzhou Milestone Pharmtech Co., Ltd. | 0571-82896630 18969958410 | sales_hz@milestonepharmtech.com | China | 4906 | 55 |
| JW & Y Pharmlab Co., Ltd. | 021-64340559 | xinyu_shi@jwypharmlab.com.cn | China | 11999 | 58 |
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