4-chloro-6,7-dimethoxyquinoline
- CAS No.
- 35654-56-9
- Chemical Name:
- 4-chloro-6,7-dimethoxyquinoline
- Synonyms
- 4-Chloro-6,7-dimethoxyquioline;6,7-DIMETHOXY-4-CHLOROQUINOLINE;4-CHLORO-6;7-DIMETHOXYQUINOLINE;oro-6,7-dimethoxyquinoL;Cabozantinib Impurity 71;Cabozantinib Chloro Analog;4-CHLORO-6,7-DIMETHOXYQUINOLINE;4-Chloro-6,7-dimethoxy-quinolin;Quinoline, 4-chloro-6,7-dimethoxy-
- CBNumber:
- CB8725015
- Molecular Formula:
- C11H10ClNO2
- Molecular Weight:
- 223.66
- MDL Number:
- MFCD07778437
- MOL File:
- 35654-56-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 132.0 to 136.0 °C |
|---|---|
| Boiling point | 325.2±37.0 °C(Predicted) |
| Density | 1.265±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 3.95±0.30(Predicted) |
| color | Pale Brown to Light Brown |
| InChI | InChI=1S/C11H10ClNO2/c1-14-10-5-7-8(12)3-4-13-9(7)6-11(10)15-2/h3-6H,1-2H3 |
| InChIKey | WRVHQEYBCDPZEU-UHFFFAOYSA-N |
| SMILES | N1C2C(=CC(OC)=C(OC)C=2)C(Cl)=CC=1 |
| CAS DataBase Reference | 35654-56-9(CAS DataBase Reference) |
| UNSPSC Code | 12352200 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319-H315-H335 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 25 | |||||||||
| Safety Statements | 45-24/25 | |||||||||
| RIDADR | UN2811 | |||||||||
| WGK Germany | WGK 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29334900 | |||||||||
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
|||||||||
| Hazard Classifications | Acute Tox. 3 Oral | |||||||||
| NFPA 704 |
|
4-chloro-6,7-dimethoxyquinoline price More Price(49)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | CDS007782 | 4-chloro-6,7-dimethoxyquinoline AldrichCPR | 35654-56-9 | 250mg | $114 | 2026-04-30 | Buy |
| TCI Chemical | C2938 | 4-Chloro-6,7-dimethoxyquinoline >98.0%(GC) | 35654-56-9 | 5g | $69 | 2026-04-30 | Buy |
| TCI Chemical | C2938 | 4-Chloro-6,7-dimethoxyquinoline >98.0%(GC) | 35654-56-9 | 25g | $275 | 2026-04-30 | Buy |
| Usbiological | 161311 | 4-Chloro-6,7-dimethoxyquinoline Asreported | 35654-56-9 | 500mg | $403 | 2026-06-03 | Buy |
| AstaTech | 68445 | 4-CHLORO-6,7-DIMETHOXY-QUINOLINE 97% | 35654-56-9 | 1G | $10 | 2026-04-30 | Buy |
4-chloro-6,7-dimethoxyquinoline Chemical Properties, Uses, Production
Chemical Properties
Light brown powder
Uses
4-Chloro-6,7-dimethoxyquinoline, can be used as an intermediate for the synthesis of various pharmaceutical and biologically active compounds. It is used for the preparation of Tivozanib (T447205), and Cabozantinib (C051500), acting as anticancer agents.
Application
4-chloro-6,7-dimethoxy-quinoline can be rich for Buddhist nun with for Wo Zhani medicine as preparing antitumor drug card The key intermediate of thing molecule synthesis.
Synthesis
With 3,4-dimethoxyaniline is raw material, obtains aniline compound through nitrification, iron powder reducing, then with Ethyl chloroformate, in Feldalat NM condition cyclization, prepares 4-hydroxyquinoline compounds, after through three Chlorethoxyfos chloro obtains 4-chloro-6,7-dimethoxy-quinoline.
References
[1] Patent: WO2013/180949, 2013, A1. Location in patent: Paragraph 0170
[2] Heterocycles, 2016, vol. 92, # 10, p. 1882 - 1887
[3] Patent: WO2005/121125, 2005, A1. Location in patent: Page/Page column 41-42
[4] Patent: WO2008/48375, 2008, A1. Location in patent: Page/Page column 49
[5] Journal of the American Chemical Society, 1946, vol. 68, p. 1264
4-chloro-6,7-dimethoxyquinoline Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shandong Xuande Pharmaceutical Technology Co. LTD | 18866895588 | dingjiaying@shiningpharm.com | China | 184 | 55 |
| Shanghai Yuzhicheng Pharmaceutical Technology Co., Ltd. | 13361818591 | 2415195517@qq.com | China | 45 | 58 |
| shanghai huiyu | 15380804498 | hj.yang@nstbio.com | China | 293 | 58 |
| Shanghai He Huan Chemical Co., Ltd. | 021-60345187 13917602471 | lzz841106@aliyun.com | China | 483 | 58 |
| TIANJIN PHARMACN MEDICAL TECHNOLOGY CO.,LTD. | 022-60189726 18812034280 | 188120342808@163.com | China | 143 | 61 |
| Jiangxi Hechun Pharmaceutical Technology Co., Ltd. | 13033833208 | 3692193759@qq.com | China | 72 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | 021-50182298 021-50180596 | sales@boylechem.com | China | 2202 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| ChemFuture PharmaTech (Jiangsu) Ltd | 5108538618 | suger.wang@chemfuture.com | China | 832 | 65 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
View Latest Price from 4-chloro-6,7-dimethoxyquinoline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | 4-Chloro-6,7-dimethoxyquinoline
35654-56-9
|
$1.00-200.00 | 1KG | 99%, 99.5% Sublimated | Henan Fengda Chemical Co., Ltd | ||
 |
2026-08-20 | 4-CHLORO-6,7-DIMETHOXYQUINOLINE
35654-56-9
|
$1.10 | 1g | 99.00% | 100 Tons | Dideu Industries Group Limited | |
 |
2026-06-30 | 4-chloro-6,7-dimethoxyquinoline
35654-56-9
|
1kg | 98% | 1000kg | Shaanxi Dideu New Materials Co. Ltd |
-
- 4-Chloro-6,7-dimethoxyquinoline
35654-56-9
- $1.00-200.00
- 99%, 99.5% Sublimated
- Henan Fengda Chemical Co., Ltd
-
- 4-CHLORO-6,7-DIMETHOXYQUINOLINE
35654-56-9
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 4-chloro-6,7-dimethoxyquinoline
35654-56-9
- $0.00
- 98%
- Shaanxi Dideu New Materials Co. Ltd
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