4-Hydroxy-6,7-dimethoxyqunioline
- CAS No.
- 13425-93-9
- Chemical Name:
- 4-Hydroxy-6,7-dimethoxyqunioline
- Synonyms
- Lactic Acid Impurity 22;6,7-DIMETHOXYQUINOLINE-4-OL;4-Quinolinol,6,7-diMethoxy-;6,7-Dimethoxy-quinolin-4-ol;Cabozantinib Hydroxy Analog;6,7-DIMETHOXYQUINOLIN-4(1H)-ONE;4-HYDROXY-6,7-DIMETHOXYQUNIOLINE;4-HYDROXY-6,7-DIMETHOXYQUINOLINE;4-hydroxy-(6,7-dimethoxyqunioine;6,7-Dimethoxy-4-hydroxyquinoline
- CBNumber:
- CB4704786
- Molecular Formula:
- C11H11NO3
- Molecular Weight:
- 205.21
- MDL Number:
- MFCD07368026
- MOL File:
- 13425-93-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 227.0 to 231.0 °C |
|---|---|
| Boiling point | 370.9±37.0 °C(Predicted) |
| Density | 1.257±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly, Sonicated) |
| form | powder to crystal |
| pka | 4.26±0.40(Predicted) |
| color | Light orange to Yellow to Green |
| InChI | InChI=1S/C11H11NO3/c1-14-10-5-7-8(6-11(10)15-2)12-4-3-9(7)13/h3-6H,1-2H3,(H,12,13) |
| InChIKey | QOGPNCUTXVZQSL-UHFFFAOYSA-N |
| SMILES | N1C2C(=CC(OC)=C(OC)C=2)C(O)=CC=1 |
| CAS DataBase Reference | 13425-93-9(CAS DataBase Reference) |
| FDA UNII | BD9X7ZL9D7 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 |
| HS Code | 2933.49.7000 |
| HazardClass | IRRITANT |
4-Hydroxy-6,7-dimethoxyqunioline price More Price(42)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | D4695 | 6,7-Dimethoxy-4-hydroxyquinoline >98.0%(HPLC)(T) | 13425-93-9 | 1g | $156 | 2026-04-30 | Buy |
| TCI Chemical | D4695 | 6,7-Dimethoxy-4-hydroxyquinoline >98.0%(HPLC)(T) | 13425-93-9 | 5g | $619 | 2026-04-30 | Buy |
| Biosynth | FH43596 | 4-Hydroxy-6,7-dimethoxyquinoline | 13425-93-9 | 0.1kg | $295 | 2026-06-04 | Buy |
| Biosynth | FH43596 | 4-Hydroxy-6,7-dimethoxyquinoline | 13425-93-9 | 0.25kg | $531 | 2026-06-04 | Buy |
| Biosynth | FH43596 | 4-Hydroxy-6,7-dimethoxyquinoline | 13425-93-9 | 0.5kg | $708 | 2026-06-04 | Buy |
4-Hydroxy-6,7-dimethoxyqunioline Chemical Properties, Uses, Production
Appearance
4-Hydroxy-6,7-dimethoxyqunioline is a slightly pale yellow to yellow solid.
Uses
4-Hydroxy-6,7-dimethoxyqunioline, also called 6,7-Dimethoxy-4-quinolinol was used in the study of synthesis of ring-substituted 4-aminoquinolines and evaluation fo their antimalarial activities.
Synthesis
13436-14-1
13425-93-9
General procedure for the synthesis of 4-hydroxy-6,7-dimethoxyquinoline-3-carboxylic acid from ethyl 4-hydroxy-6,7-dimethoxyquinoline-3-carboxylate: ethyl 4-hydroxy-6,7-dimethoxyquinoline-3-carboxylate (700 mg, 2.53 mmol) was added to potassium hydroxide (450 mg, 7.6 mmol) dissolved in 20 mL of H2O/EtOH (1:1, v /v) solution. The mixture was placed in a sealed container (XP-500 Plus container) and heated using microwaves (MARS 5 Microwave System) at 180°C, 260-280 psi pressure for 50 min. Upon completion of the reaction, the mixture was cooled to room temperature and transferred to a flask. Subsequently, the solution was acidified to pH about 6 with acetic acid (about 2 mL), saturated with sodium chloride, and extracted with tetrahydrofuran (3 x 100 mL). The organic layers were combined, washed with brine and concentrated to give 6,7-dimethoxyquinolin-4-ol in 90% yield.1H NMR (400 MHz, DMSO-d6) δ ppm: 3.81 (s, 3H), 3.84 (s, 3H), 5.93 (d, J=7.3 Hz, 1H), 7.05 (s, 1H), 7.42 (s, 1H), and 7.76 (d, J=7.3 Hz, 1H).
storage
Store at room temperature.
References
[1] Patent: WO2005/121125, 2005, A1. Location in patent: Page/Page column 41-42
[2] Journal of the American Chemical Society, 1946, vol. 68, p. 1264
4-Hydroxy-6,7-dimethoxyqunioline Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shandong Xuande Pharmaceutical Technology Co. LTD | 18866895588 | dingjiaying@shiningpharm.com | China | 184 | 55 |
| Shanghai Yuzhicheng Pharmaceutical Technology Co., Ltd. | 13361818591 | 2415195517@qq.com | China | 45 | 58 |
| Ningbo jinuo chemical co., LTD | 0574-87314919 057487319282 | info@nbinno.com | China | 7046 | 58 |
| shanghai huiyu | 15380804498 | hj.yang@nstbio.com | China | 293 | 58 |
| NINGBO INNO PHARMCHEM CO.,LTD. | 15558396803 | sales@nbinno.com | China | 135 | 58 |
| TIANJIN PHARMACN MEDICAL TECHNOLOGY CO.,LTD. | 022-60189726 18812034280 | 188120342808@163.com | China | 143 | 61 |
| ChemFuture PharmaTech (Jiangsu) Ltd | 5108538618 | suger.wang@chemfuture.com | China | 832 | 65 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
View Latest Price from 4-Hydroxy-6,7-dimethoxyqunioline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-23 | 4-Hydroxy-6,7-dimethoxyqunioline
13425-93-9
|
1kg | 99%min | 20tons | HANGZHOU HAILAN CHEMICAL CO.,LTD. | ||
 |
2026-09-02 | 4-Hydroxy-6,7-dimethoxyquinoline
13425-93-9
|
$1.00-200.00 | 1KG | 99%, 99.5% Sublimated | Henan Fengda Chemical Co., Ltd | ||
 |
2026-08-20 | 4-Hydroxy-6,7-dimethoxyqunioline
13425-93-9
|
$1.10 | 1g | 99.00% | 100 Tons | Dideu Industries Group Limited |
-
- 4-Hydroxy-6,7-dimethoxyqunioline
13425-93-9
- $0.00
- 99%min
- HANGZHOU HAILAN CHEMICAL CO.,LTD.
-
- 4-Hydroxy-6,7-dimethoxyquinoline
13425-93-9
- $1.00-200.00
- 99%, 99.5% Sublimated
- Henan Fengda Chemical Co., Ltd
-
- 4-Hydroxy-6,7-dimethoxyqunioline
13425-93-9
- $1.10
- 99.00%
- Dideu Industries Group Limited
