(5-Butanoate-1H-2-indolyl)(1H-2-indolyl)-methanone
- CAS No.
- 249762-74-1
- Chemical Name:
- (5-Butanoate-1H-2-indolyl)(1H-2-indolyl)-methanone
- Synonyms
- D-65476;PDGFR Tyrosine Kinase Inhibitor II;PDGF RECEPTOR TYROSINE KINASE INHIBITOR II;[2-(1H-2-INDOLYCARBONYL)-1H-5-INDOLYL]BUTANOATE;[2-(1H-2-INDOLYLCARBONYL)-1H-5-INDOLYL]BUTANOATE;(5-Butanoate-1H-2-indolyl)(1H-2-indolyl)-methanone;Butanoic acid, 2-(1H-indol-2-ylcarbonyl)-1H-indol-5-yl ester
- CBNumber:
- CB8739506
- Molecular Formula:
- C21H18N2O3
- Molecular Weight:
- 346.38
- MDL Number:
- MFCD06411445
- MOL File:
- Mol file
- MSDS File:
- SDS
(5-Butanoate-1H-2-indolyl)(1H-2-indolyl)-methanone price More Price(1)
(5-Butanoate-1H-2-indolyl)(1H-2-indolyl)-methanone Chemical Properties, Uses, Production
Uses
D-65476 is an inhibitor of type Ⅲ receptor tyrosine kinase (Flt3). In the absence of IL-3, D-65476 inhibits the proliferation of TEL-Flt3 transfected BA/F3 cells (IC50= 0.2 μM), which can be used in the study of Flt3-driven leukemia[1].
Biological Activity
Cell permeable: yes', 'Primary Target
PDGFR in swiss 3T3 cells', 'Product competes with ATP.', 'Reversible: yes', 'Target IC50: 1.1 μM inhibiting PDGFR in swiss 3T3 cells; 6.2 μ M for hPDGFβ-R-mFlt3 and 50 nM in EOL-1 cells
References
[1] Teller S, et al. Bis(1H-2-indolyl)-1-methanones as inhibitors of the hematopoietic tyrosine kinase Flt3. Leukemia. 2002;16(8):1528-1534. DOI:10.1038/sj.leu.2402630
(5-Butanoate-1H-2-indolyl)(1H-2-indolyl)-methanone Preparation Products And Raw materials
Raw materials
Preparation Products
(5-Butanoate-1H-2-indolyl)(1H-2-indolyl)-methanone Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| SynAsst Chemical. | 021-60343070 | China | 12731 | 55 | |
| TargetMol | 400-821-0310 15002144251 | xuexiang.shao@tsbiochem.com | China | 29128 | 58 |
| Supplier | Advantage |
|---|---|
| SynAsst Chemical. | 55 |
| TargetMol | 58 |
