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L-Leucinamide hydrochloride

L-Leucinamide hydrochloride structure

CAS No.: 10466-61-2

Chemical Name:: L-Leucinamide hydrochloride

Synonyms: H-Leu-NH2Cl;LEU-NH2 HCL;H-LEU-NH2 HCL;L-Leu-NH2.HCl;LEUCINE-NH2 HCL;H-L-LEU-NH2 HCL;L-Leucinamide HCl;L-LEUCINEAMIDE HCL;H-Leu-NH2·HCl ,≥99%;L-Leucinamide hydroc

CBNumber:: CB8754976

Molecular Formula:: C6H15ClN2O

Molecular Weight:: 166.65

MDL Number:: MFCD00013012

MOL File:: 10466-61-2.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 05:43:48

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L-Leucinamide hydrochloride Properties

Melting point	254256°C
alpha	9 º (c=1, H2O)
refractive index	9.8 ° (C=5, H2O)
storage temp.	Inert atmosphere,Room Temperature
Water Solubility	very faint turbidity in Water
form	Powder
color	White to off-white
optical activity	[α]25/D +10°, c = 5 in H2O
Sensitive	Hygroscopic
BRN	4237021
Major Application	peptide synthesis
InChI	1S/C6H14N2O.ClH/c1-4(2)3-5(7)6(8)9;/h4-5H,3,7H2,1-2H3,(H2,8,9);1H/t5-;/m0./s1
InChIKey	VSPSRRBIXFUMOU-JEDNCBNOSA-N
SMILES	Cl.CC(C)C[C@H](N)C(N)=O
CAS DataBase Reference	10466-61-2(CAS DataBase Reference)
UNSPSC Code	12352209
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS02,GHS05,GHS07

Signal word

Danger

Hazard statements

H225-H317-H318

Precautionary statements

P210-P280-P305+P351+P338+P310-P333+P313-P403+P235

PPE

Eyeshields, Gloves, type N95 (US)

Safety Statements

22-24/25

WGK Germany

HS Code

29241900

Storage Class

11 - Combustible Solids

NFPA 704

	1
0		1

L-Leucinamide hydrochloride price More Price(50)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	286427	L-Leucinamide hydrochloride 99%	10466-61-2	5g	$136	2026-04-30	Buy
TCI Chemical	L0094	L-Leucinamide Hydrochloride >98.0%(T)	10466-61-2	1g	$28	2026-04-30	Buy
TCI Chemical	L0094	L-Leucinamide Hydrochloride >98.0%(T)	10466-61-2	5g	$90	2026-04-30	Buy
Usbiological	281409	L-Leucine amide hydrochloride Asreported	10466-61-2	10g	$353	2026-06-03	Buy
Usbiological	281409	L-Leucine amide hydrochloride Asreported	10466-61-2	25g	$559	2026-06-03	Buy

Product number	Packaging	Price	Buy
286427	5g	$136	Buy
L0094	1g	$28	Buy
L0094	5g	$90	Buy
281409	10g	$353	Buy
281409	25g	$559	Buy

L-Leucinamide hydrochloride Chemical Properties,Uses,Production

Chemical Properties

Crystalline

Uses

L-Leucinamide Hydrochloride, is a derivative of Leucine, which is an essential amino acid, and acts as a nutrient signal to stimulate protein synthesis. L-Leucinamide Hydrochloride, is shown to be the potential elicitors of insulin secretion in rats.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

7517-19-3

10466-61-2

The general procedure for the synthesis of L-leucinamide hydrochloride from L-leucine methyl ester hydrochloride is as follows: the synthesis is an improvement on a previously published method. The raw material L-leucine methyl ester hydrochloride can be purchased from Alfa Aesar. L-Leucine methyl ester hydrochloride (1.0 g, 5.5 mmol) and methanol (10 mL) were added to a glass pressure tube, followed by a methanol solution of 7N ammonia (7.9 mL, 55 mmol). The reaction tube was sealed, heated to 50 °C and kept for 2 days. After completion of the reaction, the mixture was concentrated in vacuum. The crude product was suspended in 1,4-dioxane (10 mL) and converted to hydrochloride by addition of 1,4-dioxane solution (1.7 mL, 6.8 mmol) in 4N HCl. Mixing was facilitated by sonication. The solvent and excess HCl were removed using a rotary evaporator, 1,4-dioxane (10 mL) was added during the process to help remove excess HCl.The product was purified by recrystallization from hot isopropanol, allowing crystals to form slowly at room temperature. The recrystallized solid was placed under high vacuum to remove residual solvent. The final yield was 0.55 g (60%). The product had a melting point of 216-218 °C, a specific spin [α]D24 of +12.0° (c 0.50, methanol), and an HPLC purity (200 nm) greater than 99% and significantly lower than 0.5% of the parent leucine.1H NMR ((CD3)2SO) δ 8.29 (broad single peak, 3H), 7.96 (single peak, 1H), 7.48 (single peak, 1H), and 3.66 (multiple peaks, 1H), 1.67 (multiple peaks, 1H), 1.56 (multiple peaks, 2H), 0.92 (double peaks, J=3Hz, 3H), 0.90 (double peaks, J=3Hz, 3H).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 20, p. 5000 - 5006
[2] Journal fur Praktische Chemie - Chemiker - Zeitung, 1996, vol. 338, # 3, p. 251 - 256

L-Leucinamide hydrochloride Preparation Products And Raw materials

Raw materials

Methyl L-leucinate hydrochloride Methanol Hydrochloric acid 1,4-Dioxane Ammonia

Preparation Products

N-Cbz-D-Alanine Z-Gly-Gly-Phe-OH

L-Leucinamide hydrochloride Suppliers

Global( 235)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
INTATRADE GmbH	+49 3493/605464	sales@intatrade.de	Germany	3563	66
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Adamas Reagent, Ltd.	400-6009262 15618770481	yhx@titansci.com	China	14098	59
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
Chemsky (shanghai) International Co.,Ltd	021-50135380	shchemsky@sina.com	China	15350	60
Shandong Xiya Chemical Co., Ltd	13355009207 13355009207	3007715519@qq.com	China	18722	57

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
INTATRADE GmbH	66
Alfa Aesar	84
TCI (Shanghai) Development Co., Ltd.	81
Energy Chemical	61
Adamas Reagent, Ltd.	59
Shanghai Hanhong Scientific Co.,Ltd.	64
Chemsky (shanghai) International Co.,Ltd	60
Shandong Xiya Chemical Co., Ltd	57

View Lastest Price from L-Leucinamide hydrochloride manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-07-06	L-Leucinamide hydrochloride 10466-61-2	$100.00	1KG	99%		Career Henan Chemical Co

L-Leucinamide hydrochloride
10466-61-2
$100.00
99%
Career Henan Chemical Co

L-Leucinamide hydrochloride Spectrum

L-Leucinamide hydrochloride(10466-61-2)MS L-Leucinamide hydrochloride(10466-61-2)¹HNMR L-Leucinamide hydrochloride(10466-61-2)IR1 L-Leucinamide hydrochloride(10466-61-2)IR2 L-Leucinamide hydrochloride(10466-61-2)Raman

10466-61-2(L-Leucinamide hydrochloride)Related Search:

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L-LeucinamideHydrochlorideA.R. Pentanamide, 2-amino-4-methyl-, monohydrochloride, (2S)- (r)-2-amino-4-methylvaleramide H-LEU-NH2 HCL (S)-2-amino-4-methylvaleramide monohydrochloride L-Leucinamide HCl L-Leucinamide Hydrochloride L-Leucine amide hydrochloride≥ 99% (HPLC) L-Leucimide hydrochloride H-Leu-NH2·HCl (HPLC>98%) L-LEUCINAMIDE HYDROCHLORIDE extrapure L-Leucinamide hydrochloride, 98+% Pentanamide, 2-amino-4-methyl-, monohydrochloride, (S)- Leucinamide·hydrochloride Leucine amide hydrochloride L-Leucinamide hydrochloride,99% H-Leu-NH2·HCl ,≥99% L-Leucine amide·hydrochloride salt (H-Leu-NH2·HCl) L-Leucinamide hydroc H-Leu-NH2Cl (S)-2-aMino-4-MethylpentanaMide hydrochloride L-Leu-NH2.HCl (2S)-2-amino-4-methylpentanamide hydrochloride (2S)-2-amino-4-methyl-pentanamide hydrochloride (2S)-2-amino-4-methyl-valeramide hydrochloride L-LEUCINAMIDE HYDROCHLORIDE L-LEUCINEAMIDE HCL L-LEUCINE AMIDE HYDROCHLORIDE L-LEUCINE AMIDE MONOHYDROCHLORIDE LEU-NH2 HCL LEUCINE-NH2 HCL L-Leucinamide hydrochloride 99% H-L-LEU-NH2 HCL Pentanamide,2-amino-4-methyl-, hydrochloride (1:1), (2S)- L-LeucinamideHydrochloride> L-Leucinamide hydrochloride USP/EP/BP L-Leucinamide hydrochloride L-Leucine Amide hydrochloride, extra pure, 99% 10466-61-2 C6H14N2OHCl C6H14N2OCl C6H14N2O稨Cl CH32CHCH2CHNH2CONH2HCl Amino Acid Derivatives AMINE Leucine Specialty Synthesis Peptide Synthesis Amino Acid Derivatives Leucine Peptide Synthesis Leucine [Leu, L] Amino Acid Derivatives Amino Acids