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Methyl L-leucinate hydrochloride

Methyl L-leucinate hydrochloride structure

CAS No.: 7517-19-3

Chemical Name:: Methyl L-leucinate hydrochloride

Synonyms: H-Leu-OMe;L-LEUCINE METHYL ESTER HYDROCHLORIDE;H-LEU-OME·HCL;(S)-Methyl 2-aMino-4-Methylpentanoate hydrochloride;H-LEU-OME HCL;L-Leu-OMe.HCL;L-LEUCINE METHYL ESTER HCL;LEUCINE METHYL ESTER HYDROCHLORIDE;Methyl (2S)-2-aMino-4-Methylpentanoate hydrochloride;TYRO-002

CBNumber:: CB9160343

Molecular Formula:: C7H16ClNO2

Molecular Weight:: 181.66

MDL Number:: MFCD00012494

MOL File:: 7517-19-3.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 04:37:50

Product description	Number	Pack Size	Price
L-Leucine methyl ester hydrochloride 98%	L1002	10G	$44.2
L-Leucine methyl ester hydrochloride 98%	L1002	25G	$94.6
L-Leucine Methyl Ester Hydrochloride >98.0%(T)	L0155	25g	$65
L-Leucine Methyl Ester Hydrochloride	453355	25g	$403
L-Leucine Methyl Ester Hydrochloride	453355	100g	$785
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Methyl L-leucinate hydrochloride Properties

Melting point	151-153 °C(lit.)
alpha	20 º (c=4.5, MeOH)
refractive index	13 ° (C=2, H2O)
storage temp.	Inert atmosphere,2-8°C
solubility	H₂O: 50 mg/mL, clear, colorless
form	Crystals or Crystalline Powder
color	White
optical activity	[α]22/D +13°, c = 2 in H2O
Water Solubility	soluble
Sensitive	Hygroscopic
BRN	3595133
Major Application	peptide synthesis
InChI	InChI=1/C7H15NO2.ClH/c1-5(2)4-6(8)7(9)10-3;/h5-6H,4,8H2,1-3H3;1H/t6-;/s3
InChIKey	DODCBMODXGJOKD-UZHXKHNSNA-N
SMILES	[C@H](N)(CC(C)C)C(=O)OC.Cl \|&1:0,r\|
CAS DataBase Reference	7517-19-3(CAS DataBase Reference)
UNSPSC Code	12352209
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P305+P351+P338

PPE

Eyeshields, Gloves, type N95 (US)

Hazard Codes

Risk Statements

36/37/38

Safety Statements

22-24/25-36/37/39-27-26

WGK Germany

HazardClass

IRRITANT

HS Code

29224995

Storage Class

11 - Combustible Solids

NFPA 704

	0
0		0

Methyl L-leucinate hydrochloride price More Price(93)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	L1002	L-Leucine methyl ester hydrochloride 98%	7517-19-3	10G	$44.2	2026-04-30	Buy
Sigma-Aldrich	L1002	L-Leucine methyl ester hydrochloride 98%	7517-19-3	25G	$94.6	2026-04-30	Buy
TCI Chemical	L0155	L-Leucine Methyl Ester Hydrochloride >98.0%(T)	7517-19-3	25g	$65	2026-04-30	Buy
Usbiological	453355	L-Leucine Methyl Ester Hydrochloride	7517-19-3	25g	$403	2026-06-03	Buy
Usbiological	453355	L-Leucine Methyl Ester Hydrochloride	7517-19-3	100g	$785	2026-06-03	Buy

Product number	Packaging	Price	Buy
L1002	10G	$44.2	Buy
L1002	25G	$94.6	Buy
L0155	25g	$65	Buy
453355	25g	$403	Buy
453355	100g	$785	Buy

Methyl L-leucinate hydrochloride Chemical Properties,Uses,Production

Chemical Properties

Crystalline

Uses

L-Leucine methyl ester is a protected form of L-Leucine (L330110). L-Leucine is an essential amino acid that induces a sharp decrease in blood glucose levels in individuals with idiopathic familial hypoglycemia, but has no known effects on normal, healthy individuals. L-Leucine also acts as an Isoleucine (I820210) antagonist in the rat, causing delays in growth, and is a potential tumour promoter of bladder cancer.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

67-56-1

61-90-5

7517-19-3

Under ice bath conditions, 60 mL of methanol was added to a 100 mL round bottom flask. 4 mL of sulfoxide chloride (SOCl2) was added slowly and dropwise through a constant pressure dropping funnel (with a drying tube fitted at the top), while the resulting off-gas was absorbed using NaOH solution. After stirring the reaction mixture for 1 h, 8 mmol of L-leucine was added and stirring was continued for 30 min at room temperature. Subsequently, the reaction system was warmed up to 66 °C and the reaction was refluxed for 6 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) with an ethanol solution of 2% ninhydrin as the color developer until the raw material spot disappeared. After completion of the reaction, the solvent was removed by distillation under reduced pressure to give L-leucine methyl ester hydrochloride in 100% yield.

References

[1] Patent: US2014/206741, 2014, A1. Location in patent: Paragraph 0121
[2] Journal of Organic Chemistry, 2003, vol. 68, # 12, p. 5006 - 5008
[3] Synthetic Communications, 2010, vol. 40, # 8, p. 1161 - 1179
[4] Bulletin des Societes Chimiques Belges, 1991, vol. 100, # 1, p. 63 - 77
[5] Chemical Biology and Drug Design, 2012, vol. 79, # 2, p. 216 - 222

Methyl L-leucinate hydrochloride synthesis

Synthesis of Methyl L-leucinate hydrochloride from L-Leucine

Methyl L-leucinate hydrochloride Preparation Products And Raw materials

Raw materials

L-Leucine, N-(methoxycarbonyl)-, methyl ester Z-LEU-OME methyl L-leucinate L-Leucine hydrochloride BOC-L-Leucine

Methanol L-Leucine

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Preparation Products

N-Cbz-L-Leucine 1H-Pyrrole-1-acetic acid, 2-formyl-α-(2-methylpropyl)-, methyl ester N-(2-Chloroacetyl)-L-leucine methyl ester 1H-Pyrrole-1-acetic acid, 2-formyl-α-(2-methylpropyl)- (R)-(+)-2-AMINO-4-METHYL-1,1-DIPHENYL-1-PENTANOL

Z-VAL-LEU-OH

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Methyl L-leucinate hydrochloride Suppliers

Global( 416)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shaanxi Dideu Medichem Co. Ltd	+86-17392712779	1097@dideu.com	China	3989	58
Sichuan HongRi Pharma-Tech Co.,Ltd	+86-15680023009	ni@enlaibio.com	China	1103	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29626	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32998	60
AB PharmaTech,LLC	323-480-4688	sales@acrospharmatech.com	United States	988	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29766	58
Xiamen AmoyChem Co., Ltd	+86-86-5926051114	sales@amoychem.com	China	6339	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19935	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63645	58
CONIER CHEM AND PHARMA LIMITED		sales@conier.com	China	49906	58

Supplier	Advantage
Shaanxi Dideu Medichem Co. Ltd	58
Sichuan HongRi Pharma-Tech Co.,Ltd	58
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
AB PharmaTech,LLC	55
career henan chemical co	58
Xiamen AmoyChem Co., Ltd	58
BOC Sciences	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58

View Lastest Price from Methyl L-leucinate hydrochloride manufacturers

Update time	Product	Min. Order	Purity	Supply Ability	Manufacturer
2026-08-14	Methyl L-leucinate hydrochloride 7517-19-3	1KG	98.5～101.5%,USP	20tons/month	WUHAN FORTUNA CHEMICAL CO., LTD
2026-08-13	Methyl L-leucinate hydrochloride 7517-19-3		0.99		RongNa Biotechnology Co.,Ltd
2026-08-13	L-Leu-OMe.HCl 7517-19-3	1kg	98%	1T+	Sichuan HongRi Pharma-Tech Co.,Ltd

Methyl L-leucinate hydrochloride
7517-19-3
$0.00
98.5～101.5%,USP
WUHAN FORTUNA CHEMICAL CO., LTD

Methyl L-leucinate hydrochloride
7517-19-3
0.99
RongNa Biotechnology Co.,Ltd

L-Leu-OMe.HCl
7517-19-3
98%
Sichuan HongRi Pharma-Tech Co.,Ltd

Methyl L-leucinate hydrochloride Spectrum

Methyl L-leucinate hydrochloride(7517-19-3)¹HNMR Methyl L-leucinate hydrochloride(7517-19-3)IR Methyl L-leucinate hydrochloride(7517-19-3)FT-IR Methyl L-leucinate hydrochloride(7517-19-3)Raman

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Methyl L-Leucyl-L-Leucine methyl ester (hydrochloride) H-LEU-PHE-OH

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L-Leucine Methyl ester hydrochloride 98% L-Leucine Methyl Ester Hydrochloride, 97+% L-Leucine methyl ester hydrochloride99+% Methyl L-leucite hydrochloride Methyl L-Leucinate Hydrochloride,99%e.e. (2S)-Methyl 2-amino-4-methylpentanoate hydrochloride L-Leucine methyl·hydrochloric acid L-Leucine methyl est Leucine,methyl ester,HCl L-leucinate hydrochloride TYRO-002 (S)-2-AMINO-4-METHYL-PENTANOIC ACID METHYL ESTERHYDROCHLORIDE L-LEUCINE METHYL ESTER HCL L-LEUCINE METHYL ESTER HYDROCHLORIDE SALT LEUCINE METHYL ESTER HYDROCHLORIDE LEUCINE-OME HCL METHYL L-LEUCINATE HYDROCHLORIDE H-LEU-OME HYDROCHLORIDE H-L-LEU-OME HCL L-Leucine methylesther HYDROCHLORIDE L-LEUCINE METHYL ESTER HYDROCHLORIDE, 98 % LL-LEUCINE METHYL ESTER HYDROCHLORIDE L-LENCINE METHYL ESTER HYDROCHLORIDE L-LeucineMethylEsterHydrochloride> eucine MethyL METHYL L-LEUCINATE HYDROCHLORIDE 7517-19-3 Methyl L-leucinate hydrochloride USP/EP/BP L-Leucine, methyl ester, hydrochloride (1:1) L-Leucine methyl ester hydrochloride L-Leucine methy ester hydrochloride H-Leu-OMe.HCI (S)-Methyl 2-aMino-4-Methylpentanoate hydrochloride H-LEU-OME HCL H-LEU-OME·HCL H-Leu-OMe L-Leu-OMe.HCL L-LEUCINE METHYL ESTER HYDROCHLORIDE Methyl (2S)-2-aMino-4-Methylpentanoate hydrochloride 7517-19-3 CH32CHCH2CHNH2COOCH3HCl AMINE Amino Acid Methyl Esters Protected & Labeled Amino Acids Amino Acids (C-Protected) Leucine Peptide Synthesis Specialty Synthesis Amino Acid Derivatives Peptide Synthesis Amino Acids Leucine [Leu, L] Amino Acids and Derivatives Amino Acid Methyl Esters Amino Acids (C-Protected) Biochemistry Amino hydrochloride Protected Amino Acids Amino Acid Derivatives