tert-Butyl thiophen-2-ylcarbamate
- CAS No.
- 56267-50-6
- Chemical Name:
- tert-Butyl thiophen-2-ylcarbamate
- Synonyms
- NSC 263609;AKOS 92405;BUTTPARK 97\57-48;2-(N-Boc-amino)thiophene;TERT-BUTYL 2-THIENYLCARBAMATE;tert-Butyl thien-2-ylcarbamate;2-Aminothiophene, 2-BOC protected;tert-Butyl thiophen-2-ylcarbaMate;TERT-BUTYL N-(2-THIENYL)CARBAMATE;2-Aminothiophene, N-BOC protected
- CBNumber:
- CB8784339
- Molecular Formula:
- C9H13NO2S
- Molecular Weight:
- 199.27
- MDL Number:
- MFCD02677742
- MOL File:
- 56267-50-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 151 °C |
|---|---|
| Boiling point | 238.1±13.0 °C(Predicted) |
| Density | 1.186±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C(protect from light) |
| form | solid |
| pka | 13.63±0.70(Predicted) |
| color | Pale grey |
| InChI | InChI=1S/C9H13NO2S/c1-9(2,3)12-8(11)10-7-5-4-6-13-7/h4-6H,1-3H3,(H,10,11) |
| InChIKey | QTXXTRMGTVEBIN-UHFFFAOYSA-N |
| SMILES | C(OC(C)(C)C)(=O)NC1SC=CC=1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302+H312+H332-H315-H319 |
| Precautionary statements | P501-P261-P270-P271-P264-P280-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330-P302+P352+P312-P304+P340+P312 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| HS Code | 2934999090 |
tert-Butyl thiophen-2-ylcarbamate price More Price(59)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Activate Scientific | AS20614 | 2-(N-Boc-amino)thiophene 97% | 56267-50-6 | 1g | $29 | 2026-06-04 | Buy |
| Activate Scientific | AS20614 | 2-(N-Boc-amino)thiophene 97% | 56267-50-6 | 5g | $75 | 2026-06-04 | Buy |
| Activate Scientific | AS20614 | 2-(N-Boc-amino)thiophene 97% | 56267-50-6 | 25g | $233 | 2026-06-04 | Buy |
| Chem-Impex | 29825 | tert-Butyl N-(2-thienyl)carbamate ≥96%(NMR) | 56267-50-6 | 250MG | $65.4 | 2026-05-19 | Buy |
| Chem-Impex | 29825 | tert-Butyl N-(2-thienyl)carbamate ≥96%(NMR) | 56267-50-6 | 1G | $138.61 | 2026-05-19 | Buy |
tert-Butyl thiophen-2-ylcarbamate Chemical Properties,Uses,Production
Structure
Tert-butyl thiophen-2-ylcarbamate, C9H13NO2S, is a precursor in synthesising diimine ligands suitable for metal complex formation. This compound exhibits intramolecular methyl C7—H···O1 and C8—H···O1 interactions [2.938 (4) and 3.109 (4), respectively] in addition to bulky tert -butyl groups. These two features in tandem allow the packing in the crystal to be nearly perpendicular [the angle between adjacent thiophene rings = 74.83 (7)°]. An intermolecular N1—H···O1i hydrogen bond gives a one-dimensional chain which extends along [0 0 1].
Chemical Properties
White to off-white crystalline powder
Synthesis
To a solution of thiophenecarboxylic acid (0.5 g, 3.90 mmol) in tBuOH (10 ml) was added Et3N (0.571 ml, 4.10 mmol) and DPPA (0.883 ml, 4.10 mmol). The solution was heated at 90 °C for 4 hours. The reaction mixture was cooled to RT, and the solvent was removed from the vacuum. The residue was treated with benzene, and the solution was washed with 5 per cent citric acid and NaHCO3. Solid was filtered off, and the filtrate was washed with brine. The organic layer was dried (MgSO4), concentrated in vacuo and the residue was purified by silica gel column chromatography (EtOAc/hexanes) to obtain tert-butyl thiophen-2-ylcarbamate (0.39 g, 50percent yield). 1H NMR (400 MHz, DMSO-d6): δ 10.4 (brs, 1H), 6.84 (dd, J = 1.6, and 5.2 Hz, 1H), 6.75 (dd, J = 4.0, and 5.6 Hz, 1H), 6.48 (dd, J= 1.6, and 4.0 Hz, 2H), 1.45 (s, 9H); MS (ESI) m/z: 222.0 (M+22+H+).
References
[1] Journal of Medicinal Chemistry, 1991, vol. 34, # 5, p. 1594 - 1605
[2] Patent: US2007/105864, 2007, A1. Location in patent: Page/Page column 151
[3] Patent: US2007/117804, 2007, A1. Location in patent: Page/Page column 77
[4] Journal of Medicinal Chemistry, 2002, vol. 45, # 20, p. 4513 - 4523
[5] Journal of Medicinal Chemistry, 2007, vol. 50, # 20, p. 4898 - 4908
tert-Butyl thiophen-2-ylcarbamate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 9992 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| PharmaBlock Sciences (Nanjing),Inc. | 025-86918202 4000255188 | sales@pharmablock.com | China | 5000 | 55 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd. | 21-57721279 18121011378 | sales@shydchem.com.cn | China | 998 | 56 |
| Tetranov Biopharm | 13526569071 | sales@leadmedpharm.com | China | 7882 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Shanghai Sunway Pharmaceutical Technology Co., Ltd | 13761987713 | hxzheng@sunwaypharm.cn | China | 8663 | 57 |
| Shanghai ZaiQi Bio-Tech Co., Ltd. | 021-54824098, 021-37212705 021-37212706, 13391256916 | sales@chemzq.com | China | 569 | 55 |
| Shanghai civi chemical technology co.,Ltd | 86-21-34053660 | sale@labgogo.com | China | 9853 | 52 |
View Lastest Price from tert-Butyl thiophen-2-ylcarbamate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | TERT-BUTYL N-(2-THIENYL)CARBAMATE
56267-50-6
|
$1.10 | 1g | 99.00% | 100 Tons | Dideu Industries Group Limited | |
 |
2019-12-20 | TERT-BUTYL N-(2-THIENYL)CARBAMATE
56267-50-6
|
$1.00 | 1g | 99% | 1000KGS | Career Henan Chemical Co |
-
- TERT-BUTYL N-(2-THIENYL)CARBAMATE
56267-50-6
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- TERT-BUTYL N-(2-THIENYL)CARBAMATE
56267-50-6
- $1.00
- 99%
- Career Henan Chemical Co
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