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ChemicalBook >> CAS DataBase List >>5-Pyrimidinecarbonitrile, 4-[4-cyano-2-(methylsulfonyl)phenyl]-1,2,3,4-tetrahydro-3,6-dimethyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-, (4R)-

5-Pyrimidinecarbonitrile, 4-[4-cyano-2-(methylsulfonyl)phenyl]-1,2,3,4-tetrahydro-3,6-dimethyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-, (4R)-

5-Pyrimidinecarbonitrile, 4-[4-cyano-2-(methylsulfonyl)phenyl]-1,2,3,4-tetrahydro-3,6-dimethyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-, (4R)- Structure
5-Pyrimidinecarbonitrile, 4-[4-cyano-2-(methylsulfonyl)phenyl]-1,2,3,4-tetrahydro-3,6-dimethyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-, (4R)- structure
CAS No.
2446175-39-7
Chemical Name:
5-Pyrimidinecarbonitrile, 4-[4-cyano-2-(methylsulfonyl)phenyl]-1,2,3,4-tetrahydro-3,6-dimethyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-, (4R)-
Synonyms
5-Pyrimidinecarbonitrile, 4-[4-cyano-2-(methylsulfonyl)phenyl]-1,2,3,4-tetrahydro-3,6-dimethyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-, (4R)-
CBNumber:
CB88382298
Molecular Formula:
C22H17F3N4O3S
Molecular Weight:
474.46
MDL Number:
MFCD32197315
MOL File:
2446175-39-7.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-04-24 14:58:48
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5-Pyrimidinecarbonitrile, 4-[4-cyano-2-(methylsulfonyl)phenyl]-1,2,3,4-tetrahydro-3,6-dimethyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-, (4R)- Properties

Boiling point 626.7±55.0 °C(Predicted)
Density 1.49±0.1 g/cm3(Predicted)
pka -4.16±0.70(Predicted)
form Solid
color White to off-white

5-Pyrimidinecarbonitrile, 4-[4-cyano-2-(methylsulfonyl)phenyl]-1,2,3,4-tetrahydro-3,6-dimethyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-, (4R)- price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth WXD17539 (R)-BAY-85-8501 2446175-39-7 10mg $892.7 2026-06-05 Buy
Biosynth WXD17539 (R)-BAY-85-8501 2446175-39-7 25mg $1455.5 2026-06-05 Buy
Biosynth WXD17539 (R)-BAY-85-8501 2446175-39-7 50mg $2328.5 2026-06-05 Buy
ChemScene CS-0101215 (R)-BAY-85-8501 99.09% 2446175-39-7 5mg $487 2026-06-04 Buy
ChemScene CS-0101215 (R)-BAY-85-8501 99.09% 2446175-39-7 10mg $726 2026-06-04 Buy
Product number Packaging Price Buy
WXD17539 10mg $892.7 Buy
WXD17539 25mg $1455.5 Buy
WXD17539 50mg $2328.5 Buy
CS-0101215 5mg $487 Buy
CS-0101215 10mg $726 Buy

5-Pyrimidinecarbonitrile, 4-[4-cyano-2-(methylsulfonyl)phenyl]-1,2,3,4-tetrahydro-3,6-dimethyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-, (4R)- Chemical Properties, Uses, Production

Uses

(R)-BAY-85-8501 is the less active Enantiomer of BAY-85-8501. BAY-85-8501 is a selective and potent inhibitor of Human Neutrophil Elastase (HNE), with an IC50 of 65 pM[1].

References

[1] Von Nussbaum F, et al. Freezing the Bioactive Conformation to Boost Potency: The Identification of BAY 85-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases. ChemMedChem. 2015 Jul;10(7):1163-73. DOI:10.1002/cmdc.201500131

5-Pyrimidinecarbonitrile, 4-[4-cyano-2-(methylsulfonyl)phenyl]-1,2,3,4-tetrahydro-3,6-dimethyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-, (4R)- Preparation Products And Raw materials

Raw materials

Preparation Products

5-Pyrimidinecarbonitrile, 4-[4-cyano-2-(methylsulfonyl)phenyl]-1,2,3,4-tetrahydro-3,6-dimethyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-, (4R)- Suppliers

Global Suppliers ( 6)
Supplier Tel Email Country ProdList Advantage
Beijing Solarbio Science & Tecnology Co., Ltd. 17801761073 18101056239 3193328036@qq.com China 28150 68
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11123 58
RD International Technology Co., Limited 18024082417 market@ubiochem.com China 9831 58
Supplier Advantage
Beijing Solarbio Science & Tecnology Co., Ltd. 68
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
RD International Technology Co., Limited 58

2446175-39-7 (5-Pyrimidinecarbonitrile, 4-[4-cyano-2-(methylsulfonyl)phenyl]-1,2,3,4-tetrahydro-3,6-dimethyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-, (4R)-) Related Search:

5-Pyrimidinecarbonitrile, 4-[4-cyano-2-(methylsulfonyl)phenyl]-1,2,3,4-tetrahydro-3,6-dimethyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-, (4R)- Bay 85-8501 AZD 9668 4,4′-dihydroxydiphenyl disulfide Lonodelestat TFA
AE-3763

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5-Pyrimidinecarbonitrile, 4-[4-cyano-2-(methylsulfonyl)phenyl]-1,2,3,4-tetrahydro-3,6-dimethyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-, (4R)- 2446175-39-7