fenspiride
- CAS No.
- 5053-06-5
- Chemical Name:
- fenspiride
- Synonyms
- DESP;FUBMN24;FUB-MN24;Fenspirid;fenspiride;Fenspiridum;Fenspiride-d5;fenspiride USP/EP/BP;8-phenethyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one;Pharmaceutical intermediates BKEDBP BKEDBP bkedbp
- CBNumber:
- CB8875352
- Molecular Formula:
- C15H20N2O2
- Molecular Weight:
- 260.33
- MDL Number:
- MFCD00867054
- MOL File:
- 5053-06-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 126-127 °C(Press: 2 Torr) |
|---|---|
| Density | 1.19±0.1 g/cm3(Predicted) |
| pka | 12.44±0.20(Predicted) |
| form | Solid:particulate/powder |
| color | White to off-white |
| LogP | 1.798-1.802 at 20℃ and pH6 |
| FDA UNII | S983QC7HKM |
| ATC code | R03BX01,R03DX03 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS08,GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H412-H302-H361 |
| Precautionary statements | P201-P202-P281-P308+P313-P405-P501-P264-P270-P301+P312-P330-P501-P273-P501 |
| REACH Registrations | Active |
fenspiride price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| aablocks | AA00DCDB | Fenspiride 95% | 5053-06-5 | 50mg | $224 | 2026-05-28 | Buy |
| Crysdot | CD11114446 | Fenspiride 97% | 5053-06-5 | 1g | $375 | 2026-05-26 | Buy |
| Crysdot | CD11114446 | Fenspiride 97% | 5053-06-5 | 5g | $1125 | 2026-05-26 | Buy |
| Chemenu | CM124411 | 8-phenethyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one 97% | 5053-06-5 | 1g | $351 | 2026-05-26 | Buy |
| Chemenu | CM124411 | 8-phenethyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one 97% | 5053-06-5 | 5g | $1052 | 2026-05-26 | Buy |
fenspiride Chemical Properties,Uses,Production
Originator
Viarespan,Servier,France,1969
Uses
Bronchodilator;anti-adrenergic (β-receptor).
Definition
ChEBI: 8-(2-phenylethyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one is an azaspiro compound.
Manufacturing Process
A solution of 192 g of 1-phenethyl-4-hydroxy-4-aminomethyl piperidine in 800
cc of diethylcarbonate is heated for 2 hours to reflux at about 80°C in the
presence of sodium methylate (prepared for immediate use from 2 g of
sodium). After this time, the ethyl alcohol formed during the reaction is slowly
distilled while the maximum temperature is reached. The excess ethyl
carbonate is distilled under reduced pressure. A crystallized residue is then
obtained, which is stirred with 400 cc of water and 400 cc of ether. The
solution is filtered and 125 g (77.6%) of practically pure product melting at
232°C to 233°C, are obtained.
The starting material was prepared in a yield of 58% by reduction of the
corresponding cyanohydrin. It in turn was prepared from 1-(2-phenylethyl)-4-
piperidone and potassium cyanide to give the cyanohydrin which was reduced
by lithium aluminum hydride.
Therapeutic Function
Bronchodilator
Pharmaceutical Applications
Fenspiride is an antagonist of 5-hydroxytryptamine, whose effect on bronchial smooth muscle expansion is between isoproterenol and theophylline. It also has the effect of unobtrusion-free respiratory tract and air resistance elimination in the lungs. It has the effect of antitussive, antipyretic, analgesic and anti-inflammatory, and the antipyretic and analgesic effect is better than aminopyrine and the anti-inflammatory effect is stronger than bute.
fenspiride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| LGM Pharma | 1-(800)-881-8210 | inquiries@lgmpharma.com | United States | 2110 | 70 |
| Tianjin Branch Chong pharmaceutical intermediates Co., Ltd. | 022-60116533 13207668525 | saleskc@scipharmacn.com | China | 360 | 58 |
| Hangzhou Sage Chemical Co., Ltd. | +86057186818502 13588463833 | info@sagechem.com | China | 10265 | 58 |
| Shanghai Witofly Chemical Co.,Ltd | sales@witofly.com | China | 2853 | 52 | |
| HBCChem, Inc. | +1-510-219-6317 | sales@hbcchem.com | United States | 10628 | 60 |
| Hubei Jusheng Technology Co.,Ltd | 027-59599241 18871490274 | 1400878000@qq.com | China | 9506 | 58 |
| Chizhou Kailong Import and Export Trade Co., Ltd. | xg01_gj@163.com | China | 9413 | 50 | |
| JW & Y Pharmlab Co., Ltd. | 021-64340559 | xinyu_shi@jwypharmlab.com.cn | China | 11999 | 58 |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9909 | 65 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
Related articles
- Exploring Fenspiride: Synthesis, Components, and Pharmacological Insights in Respiratory Therapy
- Fenspiride is a drug that occupies a unique niche in the pharmaceutical world due to its versatile pharmacological properties.
- Apr 19,2024
- Fenspiride: Mechanism, Bioactivity and Chemical and toxicological studies
- Fenspiride is mainly used for chronic bronchitis, bronchial asthma, chronic respiratory insufficiency and so on.
- Dec 20,2022
View Lastest Price from fenspiride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-13 | fenspiride
5053-06-5
|
0.99 | RongNa Biotechnology Co.,Ltd | ||||
 |
2026-08-20 | fenspiride
5053-06-5
|
$1.10 | 1g | 99.0% Min | 100 Tons | Dideu Industries Group Limited | |
 |
2026-04-21 | Fenspiride
5053-06-5
|
$1520.00-2500.00 | 10g | TargetMol Chemicals Inc. |
-
- fenspiride
5053-06-5
- 0.99
- RongNa Biotechnology Co.,Ltd
-
- fenspiride
5053-06-5
- $1.10
- 99.0% Min
- Dideu Industries Group Limited
-
- Fenspiride
5053-06-5
- $1520.00-2500.00
- TargetMol Chemicals Inc.
5053-06-5(fenspiride)Related Search:
1of4
