Lorcainide
- CAS No.
- 59729-31-6
- Chemical Name:
- Lorcainide
- Synonyms
- R-15889;Lorcamide;Lopantrol;Ro-13。1042;Lorcainide;Lorivox：Remivox;Lorcainide USP/EP/BP;N-(4-chlorophenyl)-2-phenyl-N-(1-propan-2-ylpiperidin-4-yl)acetamide;N-(4-Chlorophenyl)-N-[1-(1-methylethyl)piperidin-4-yl]benzeneacetamide;N-(4-Chlorophenyl)-N-[1-(1-methylethyl)-4-piperidinyl]benzeneacetamide
- CBNumber:
- CB8875468
- Molecular Formula:
- C22H27ClN2O
- Molecular Weight:
- 370.92
- MDL Number:
- MFCD00242744
- MOL File:
- 59729-31-6.mol
| Melting point | 263 °C |
|---|---|
| Boiling point | 503.0±50.0 °C(Predicted) |
| Density | 1.161±0.06 g/cm3(Predicted) |
| pka | 9.48±0.20(Predicted) |
| FDA UNII | KGJ2T0N7IQ |
| ATC code | C01BC07 |
SAFETY
Risk and Safety Statements
| Toxicity | LD50 in male mice, male and female rats (mg/kg): 18.8, 19.3, 18.6 i.v.; 483, 395, 435 orally (Barton, Marsboom) |
|---|
Lorcainide Chemical Properties, Uses, Production
Chemical Properties
Acute toxicity LD50 male mice, male rats, female rats (mg/kg): 18.8, 19.3, 18.6 IV; 483, 395, 435 oral. Lorcainide Hydrochloride (Lorcainide Hydrochloride): c22h27cln2OHCl.[58934-46-6]. White crystals from 2-propanone and 2-propanol, melting point 263°C.
Originator
Remivox,Janssen,W. Germany,1980
Uses
Cardiac depressant (anti-arrhythmic).
Definition
ChEBI: Lorcainide is a member of acetamides.
Manufacturing Process
To a stirred suspension of 5 parts of N-(4-chlorophenyl)-N-(4-piperidinyl) benzeneacetamide, 5 parts of sodium carbonate, a few crystals of potassium iodide in 200 parts of butanol is added dropwise 4 parts of 2-bromopropane at room temperature. After the addition is complete, the whole is stirred and refluxed for 20 hours. Then the second portion of 4 parts of 2-bromopropane is added and stirring and refluxing is continued for another 19 hours. The reaction mixture is cooled, filtered and the filtrate is evaporated. From the oily free base, the hydrochloride salt is prepared in the conventional manner in 1,1'-oxybisethane and 2-propanone. The precipitated solid salt is filtered off and crystallized from a mixture of 2-propanone and 2-propanol, yielding 2 parts of N-(4-chlorophenyl)-N-[1-(1-methylethyl)-4-piperidinyl] benzeneacetamide hydrochloride; melting point 263°C.
Therapeutic Function
Antiarrhythmic
Side effects
Side effects include insomnia and gastrointestinal disturbances.
Lorcainide Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| LGM Pharma | 1-(800)-881-8210 | inquiries@lgmpharma.com | United States | 2110 | 70 |
| DebyeTec.com Inc. | 18086626237 18086626237 | 2693528373@qq.com | China | 2935 | 56 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-81139210 +86-17392587031 | 1059@dideu.com | China | 9689 | 58 |
| Hubei YoungXin Pharmaceutical Tech Co.,Ltd. | 0714-3999001 19171453112 | 2881391661@qq.com | China | 10000 | 58 |
| Sinoway Industrial co., ltd. | +86-0592-5800732 +86-13806035118 | xie@china-sinoway.com | China | 1366 | 58 |
| Supplier | Advantage |
|---|---|
| LGM Pharma | 70 |
| DebyeTec.com Inc. | 56 |
| Amadis Chemical Company Limited | 58 |
| Shaanxi Dideu Medichem Co. Ltd | 58 |
| Hubei YoungXin Pharmaceutical Tech Co.,Ltd. | 58 |
| Sinoway Industrial co., ltd. | 58 |
