ethyl-3-methyl-1H-pyrazole-4-carboxylate
- CAS No.
- 85290-78-4
- Chemical Name:
- ethyl-3-methyl-1H-pyrazole-4-carboxylate
- Synonyms
- NSC 19454;Ethyl 3-Methylpyrazole-4-carboxylate;3-methylpyrazole-4-ethyl formate;Ethyl5-methylpyrazole-4-carboxylate;Ethyl 3-methyl-1H-pyrazol-4-carboxylate;ethyl-3-methyl-1H-pyrazole-4-carboxylate;ETHYL 3-METHYL-2H-PYRAZOLE-4-CARBOXYLATE;3-Methyl-1H-pyrazol-4-carboxylic acid ethyl ester;3-Methyl-1H-pyrazole-4-carboxylic Acid Ethyl Ester
- CBNumber:
- CB8969316
- Molecular Formula:
- C7H10N2O2
- Molecular Weight:
- 154.17
- MDL Number:
- MFCD00233457
- MOL File:
- 85290-78-4.mol
- MSDS File:
- SDS
| Melting point | 49-52°C |
|---|---|
| Boiling point | 280.6±20.0 °C(Predicted) |
| Density | 1.171±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,2-8°C |
| solubility | soluble in Chloroform, Methanol |
| pka | 12.26±0.50(Predicted) |
| form | solid |
| color | Light yellow to yellow |
| InChI | InChI=1S/C7H10N2O2/c1-3-11-7(10)6-4-8-9-5(6)2/h4H,3H2,1-2H3,(H,8,9) |
| InChIKey | HHYVTIKYZUMDIL-UHFFFAOYSA-N |
| SMILES | N1C=C(C(OCC)=O)C(C)=N1 |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H335-H302+H312+H332-H319 |
| Precautionary statements | P271-P261-P280 |
| WGK Germany | 3 |
| HS Code | 2933119000 |
| Storage Class | 11 - Combustible Solids |
ethyl-3-methyl-1H-pyrazole-4-carboxylate price More Price(60)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 732583 | Ethyl 3-methylpyrazole-4-carboxylate | 85290-78-4 | 250mg | $56.2 | 2023-06-20 | Buy |
| Usbiological | 274801 | Ethyl-3-methylpyrazole-4-carboxylate Asreported | 85290-78-4 | 500mg | $432 | 2026-06-03 | Buy |
| Usbiological | 274801 | Ethyl-3-methylpyrazole-4-carboxylate Asreported | 85290-78-4 | 1g | $648 | 2026-06-03 | Buy |
| Usbiological | 274801 | Ethyl-3-methylpyrazole-4-carboxylate Asreported | 85290-78-4 | 2g | $938 | 2026-06-03 | Buy |
| TRC | TRC-E925115-500MG | Ethyl 3-Methylpyrazole-4-carboxylate | 85290-78-4 | 500mg | $129 | 2026-06-03 | Buy |
ethyl-3-methyl-1H-pyrazole-4-carboxylate Chemical Properties, Uses, Production
Chemical Properties
Yellow Solid
Uses
Shows systemic antifungal activity accompanied by high levels of phytotoxicity.
Synthesis
141-97-9
4637-24-5
85290-78-4
[1255] To a solution of ethyl 3-oxobutyrate (20.0 g, 153.7 mmol) in tetrahydrofuran (THF, 150 mL) was added N,N-dimethylformamide dimethyl acetal (DMF-DMA, 19.2 g, 161.4 mmol). The reaction mixture was stirred at 70 °C for 2 hours. After completion of the reaction, the solvent was removed by concentration under reduced pressure to give the crude product. The crude product was dissolved in ethanol (EtOH, 150 mL) and hydrazine hydrate (NH2NH2-H2O, 9.2 g, 184.4 mmol) was added slowly and dropwise. The mixture was stirred at 80 °C for 16 hours. At the end of the reaction, the ethanol was removed by concentration under reduced pressure. The residue was diluted with brine (80 mL) and extracted with ethyl acetate (200 mL × 2). The organic layers were combined, dried with anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure to afford the target compound ethyl 3-methylpyrazole-4-carboxylate (257a, 21.0 g, 87.8% yield) as a pale green solid.1H NMR (CDCl3, 400 MHz): δ 7.96 (s, 1H), 4.29 (q, J = 7.2 Hz, 2H) 2.55 (s, 3H), 1.34 (t, J = 7.2 Hz, 3H).MS (ESI) m/z (M + H) + 154.8.
References
[1] Patent: WO2018/64119, 2018, A1. Location in patent: Paragraph 1255
[2] Patent: WO2016/25918, 2016, A1. Location in patent: Paragraph 105
ethyl-3-methyl-1H-pyrazole-4-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Fengcheng Meditech (Tianjin)Co., Ltd | 022-59002498-8008; 15122574756 | info@fcmeditech.com | China | 83 | 58 |
| Biokitchen | 021-021-021-31663258 13795219287 | donghuanwen@126.com | China | 3083 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| ZEROSCHEM.CO.,LTD. | 10-61256048 13810278579; | sales@zeroschem.com | China | 1400 | 59 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Nan Jing Dirise Chemcial Co.,LTD | 025-52161033 15312098939 | 2432674894@qq.com | China | 585 | 64 |
View Latest Price from ethyl-3-methyl-1H-pyrazole-4-carboxylate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-10 | ethyl-3-methyl-1H-pyrazole-4-carboxylate
85290-78-4
|
$1.00 | 1KG | 98% | 150KG | Career Henan Chemical Co |
-
- ethyl-3-methyl-1H-pyrazole-4-carboxylate
85290-78-4
- $1.00
- 98%
- Career Henan Chemical Co
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