TDI-10229
- CAS No.
- 2810887-45-5
- Chemical Name:
- TDI-10229
- Synonyms
- TDI-10229;CompoundTDI10229;TDI 10229,TDI10229;TDI-10229, 10 mM in DMSO;4-(4-benzyl-1,5-dimethyl-1H-pyrazol-3-yl)-6-chloropyrimidin-2-amine;2-Pyrimidinamine, 4-chloro-6-[1,5-dimethyl-4-(phenylmethyl)-1H-pyrazol-3-yl]-
- CBNumber:
- CB89996238
- Molecular Formula:
- C16H16ClN5
- Molecular Weight:
- 313.78
- MDL Number:
- MOL File:
- 2810887-45-5.mol
- MSDS File:
- SDS
TDI-10229 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 37674 | TDI-10229 ≥98% | 2810887-45-5 | 1mg | $33 | 2026-04-30 | Buy |
| Cayman Chemical | 37674 | TDI-10229 ≥98% | 2810887-45-5 | 5mg | $131 | 2026-04-30 | Buy |
| Cayman Chemical | 37674 | TDI-10229 ≥98% | 2810887-45-5 | 10mg | $213 | 2026-04-30 | Buy |
| Cayman Chemical | 37674 | TDI-10229 ≥98% | 2810887-45-5 | 25mg | $489 | 2026-04-30 | Buy |
| ChemScene | CS-0200347 | TDI-10229 99.00% | 2810887-45-5 | 5mg | $222 | 2026-06-04 | Buy |
TDI-10229 Chemical Properties, Uses, Production
Uses
TDI-10229 is a potent and orally bioavailable inhibitor of soluble adenylyl cyclase (sAC, ADCY10). TDI-10229 displays nanomolar inhibition of sAC in both biochemical and cellular assays (IC50 of 195 nM) and exhibits mouse pharmacokinetic properties sufficient to warrant its use as an in vivo tool compound[1][2].
in vivo
TDI-10229 (5 mg/kg; p.o.) treatment shows the Cmax, AUC and MRT were 15.5 μM, 94 μg h/mL and 3.95 hours, respectively.
| Animal Model: | Mouse[2] |
| Dosage: | 20 mg/kg |
| Administration: | P.o.(Pharmacokinetic Analysis) |
| Result: | The Cmax, AUC and MRT were 15.5 μM, 94 μg h/mL and 3.95 hours, respectively. |
References
[1] Balbach M, et al. Soluble adenylyl cyclase inhibition prevents human sperm functions essential for fertilization [published online ahead of print, 2021 Aug 31]. Mol Hum Reprod. 2021;gaab054. DOI:10.1093/molehr/gaab054
[2] Fushimi M, et al. Discovery of TDI-10229: A Potent and Orally Bioavailable Inhibitor of Soluble Adenylyl Cyclase (sAC, ADCY10). ACS Med Chem Lett. 2021;12(8):1283-1287. Published 2021 Jul 14. DOI:10.1021/acsmedchemlett.1c00273
TDI-10229 Preparation Products And Raw materials
Raw materials
Preparation Products
TDI-10229 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4860 | 55 | |
| Shanghai Beckham Medical Technology Co., Ltd | 13816613772 | huahero21@sina.com | China | 2996 | 55 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| Jinan Jiuli Biotechnology Co. , Ltd. | 15865264761 | 486064515@qq.com | China | 4999 | 58 |
| Bide Pharmatech Ltd. | 400-1647117 13681763483 | product02@bidepharm.com | China | 59929 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| Beijing Boorsen Biotechnology Co., Ltd | 400-901-9800 18611424007 | cis@bioss.com.cn | China | 9185 | 58 |
| Shanghai?Medlife?Pharm-Tech?Co.,?Ltd | 4000862158 18117107507 | vip@med-life.cn | China | 4999 | 58 |
