3-Pyridinecarbonitrile, 6-acetyl- (9CI)
- CAS No.
- 52689-19-7
- Chemical Name:
- 3-Pyridinecarbonitrile, 6-acetyl- (9CI)
- Synonyms
- 6-acetylnicotinonitrile;6-ACETYLPYRIDINE-3-CARBONITRILE;3-Pyridinecarbonitrile, 6-acetyl-;3-Pyridinecarbonitrile, 6-acetyl- (9CI)
- CBNumber:
- CB91084505
- Molecular Formula:
- C8H6N2O
- Molecular Weight:
- 146.15
- MDL Number:
- MFCD13189084
- MOL File:
- 52689-19-7.mol
- MSDS File:
- SDS
| Boiling point | 296.3±25.0 °C(Predicted) |
|---|---|
| Density | 1.19±0.1 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| pka | -0.45±0.10(Predicted) |
| Appearance | Off-white to light yellow Solid |
| InChI | InChI=1S/C8H6N2O/c1-6(11)8-3-2-7(4-9)5-10-8/h2-3,5H,1H3 |
| InChIKey | HLPONRCXYZPNFJ-UHFFFAOYSA-N |
| SMILES | C1=NC(C(C)=O)=CC=C1C#N |
3-Pyridinecarbonitrile, 6-acetyl- (9CI) price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Matrix Scientific | 301463 | 6-Acetylnicotinonitrile | 52689-19-7 | 250.00mg | $132 | 2026-05-19 | Buy |
| Matrix Scientific | 301463 | 6-Acetylnicotinonitrile | 52689-19-7 | 1.00g | $509 | 2026-05-19 | Buy |
| Matrix Scientific | 301463 | 6-Acetylnicotinonitrile | 52689-19-7 | 5.00g | $2261 | 2026-05-19 | Buy |
| aablocks | AA00E2I2 | 6-Acetylnicotinonitrile 97% | 52689-19-7 | 100mg | $37 | 2026-05-28 | Buy |
| aablocks | AA00E2I2 | 6-Acetylnicotinonitrile 97% | 52689-19-7 | 250mg | $91 | 2026-05-28 | Buy |
3-Pyridinecarbonitrile, 6-acetyl- (9CI) Chemical Properties, Uses, Production
Synthesis
928649-93-8
52689-19-7
Procedure for the synthesis of 6-acetylnicotinonitrile: The crude 6-(1-ethoxyvinyl)nicotinonitrile (14.5 g, purity about 80%) was dissolved in a mixed solution of THF (120 mL) and 2.5 N hydrochloric acid (40 mL). The reaction solution was stirred continuously for 16 hours at room temperature. Upon completion of the reaction, the pH of the reaction solution was adjusted to 7.5 with saturated aqueous NaHCO3 to quench the reaction. Subsequently, the reaction mixture was extracted with EtOAc (200 mL). The organic layer was dried with Na2SO4, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (120 g silica gel), and the eluent was hexane/EtOAc (gradient ratio from 9:1 to 3:1), which ultimately yielded the target intermediate 6-acetylnicotinonitrile (4.2 g, 65% yield).
References
[1] Patent: WO2007/28083, 2007, A2. Location in patent: Page/Page column 142
3-Pyridinecarbonitrile, 6-acetyl- (9CI) Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Ruipu Medical Technology Co., Ltd | 15895968936 | 1018762393@qq.com | China | 9992 | 58 |
| Tetranov Biopharm | 13526569071 | sales@leadmedpharm.com | China | 7881 | 64 |
| Shanghai Changyan Chem & Tech Co., Ltd. | 021-20242659 18930833303 | sales@changyanchem.cn | China | 4998 | 55 |
| Changzhou Hopschain Chemical Co.,Ltd. | 85528066 13775048983 | sales@hopschem.com | China | 31548 | 55 |
| ChengDu TongChuangYuan Pharmaceutical Co.Ltd | 028-83379370 13880556291 | tcy@tcypharm.com | China | 8696 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Bejing Famous Pharmaceutical Technology Co., Ltd. | 010-80339217; 13331045123 | 2559355526@qq.com | China | 14180 | 58 |
| Shanghai Jizhi Biochemical Technology Co. Ltd. | 021-4009004166/18616739031 18616739031 | 3007523370@qq.com | China | 40000 | 58 |
| Zhuzhou focus pharmaceutical technology co., LTD | +86-13776644403 | robert@focuspharma.cc | China | 2613 | 58 |
| Zhuhai Aobokai Biomedical Technology Co., Ltd. | 400-0628126 | sales@aobchem.com.cn | China | 19992 | 58 |
