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N-Hydroxy-5-norbornene-2,3-dicarboximide

N-Hydroxy-5-norbornene-2,3-dicarboximide structure

CAS No.: 21715-90-2

Chemical Name:: N-Hydroxy-5-norbornene-2,3-dicarboximide

Synonyms: HONB;N-HYDROXY-5-NORBORNENE-2,3-DICARBOXYLIC ACID IMIDE;HONB N-HYDROXY-5-NORBORNENE-2.3-DICARBOXYLIMIDE;N-HYDROXY-5-NORBORNENE-2,3-DICARBOXYLIMIDE;N-HYDROXY-5-NORBORNENE-2,3-DICARBOXIMIDE (HONB);2-Hydroxy-3a,4,7,7a-tetrahydro-1H-4,7-Methanoisoindole-1,3(2H)-dione;N-Hydroxy-5-norborne;LABOTEST-BB LT00112336;Endo-N-Hydroxy-5-Norbornene-2,;N-Hydroxynorborna-5-ene-2,3-dicarbimide

CBNumber:: CB9121858

Molecular Formula:: C9H9NO3

Molecular Weight:: 179.17

MDL Number:: MFCD00167583

MOL File:: 21715-90-2.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 03:38:51

Product description	Number	Pack Size	Price
N-Hydroxy-5-norbornene-2,3-dicarboxylic acid imide 97%	226378	50g	$224
N-Hydroxy-5-norbornene-2,3-dicarboximide [for Peptide Synthesis] >99.0%(T)	H0528	25g	$31
N-Hydroxy-5-norbornene-2,3-dicarboximide [for Peptide Synthesis] >99.0%(T)	H0528	250g	$167
HONB	TRC-H669550-50G	50g	$113
HONB	TRC-H669550-25G	25g	$59
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N-Hydroxy-5-norbornene-2,3-dicarboximide Properties

Melting point	165-170 °C (lit.)
Boiling point	311.69°C (rough estimate)
Density	1.2822 (rough estimate)
refractive index	1.5600 (estimate)
storage temp.	Sealed in dry,2-8°C
solubility	Soluble in ethanol
pka	9.00±0.20(Predicted)
form	Solid
color	Off-White
BRN	13540
InChI	InChI=1S/C9H9NO3/c11-8-6-4-1-2-5(3-4)7(6)9(12)10(8)13/h1-2,4-7,13H,3H2
InChIKey	ZUSSTQCWRDLYJA-UHFFFAOYSA-N
SMILES	C1(=O)C2C(C3CC2C=C3)C(=O)N1O
CAS DataBase Reference	21715-90-2(CAS DataBase Reference)
EPA Substance Registry System	4,7-Methano-1H-isoindole-1,3(2H)-dione, 3a,4,7,7a-tetrahydro-2-hydroxy- (21715-90-2)
UNSPSC Code	12352300
NACRES	NA.23

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P280a-P304+P340-P305+P351+P338-P405-P501a

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

WGK Germany

TSCA

TSCA listed

HS Code

29280090

Storage Class

11 - Combustible Solids

REACH Registrations

Active

NFPA 704

	0
2		0

N-Hydroxy-5-norbornene-2,3-dicarboximide price More Price(69)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	226378	N-Hydroxy-5-norbornene-2,3-dicarboxylic acid imide 97%	21715-90-2	50g	$224	2026-04-30	Buy
TCI Chemical	H0528	N-Hydroxy-5-norbornene-2,3-dicarboximide [for Peptide Synthesis] >99.0%(T)	21715-90-2	25g	$31	2026-04-30	Buy
TCI Chemical	H0528	N-Hydroxy-5-norbornene-2,3-dicarboximide [for Peptide Synthesis] >99.0%(T)	21715-90-2	250g	$167	2026-04-30	Buy
TRC	TRC-H669550-50G	HONB	21715-90-2	50g	$113	2026-06-03	Buy
TRC	TRC-H669550-25G	HONB	21715-90-2	25g	$59	2026-06-03	Buy

Product number	Packaging	Price	Buy
226378	50g	$224	Buy
H0528	25g	$31	Buy
H0528	250g	$167	Buy
TRC-H669550-50G	50g	$113	Buy
TRC-H669550-25G	25g	$59	Buy

N-Hydroxy-5-norbornene-2,3-dicarboximide Chemical Properties,Uses,Production

Description

N-Hydroxy-5-norbornene-2,3-dicarboximide (NHD) is a compound that has antiviral activity and is used to treat HIV infections. It inhibits the reverse transcriptase enzyme in the virus, which blocks the synthesis of viral DNA. The ferroelectric properties of NHD were first observed by observing changes in its melting point when mixed with water. This property makes it useful for diagnosis purposes. In animal studies, a dose of 5 mg/kg was found to be effective against cancer cells and the drug showed no toxicity in humans at doses up to 500 mg/day. The optimal reaction conditions for NHD are pH 6 and temperature 45 degrees Celsius.

Chemical Properties

white to off-white crystalline powder

Uses

N-Hydroxy-5-norbornene-2,3-dicarboximide(HONB) is used in solution-phase peptide synthesis. Used in the synthesis of enkephalin analogs.

Uses

Inhibits racemization in peptide synthesis using DCC as condensing agent.

Uses

It decreases racemization in peptide synthesis and inhibits formation of N-acylureas.

Purification Methods

Dissolve the imide in CHCl3, filter, evaporate and recrystallise from EtOAc. IR (nujol): max 1695, 1710 and 1770 (C=O), and 3100 (OH) cm-1. The O-acetyl derivative has m 113-114o (from EtOH) with IR bands at max 1730, 1770 and 1815 cm-1 only, and the O-benzoyl derivative has m 143-144o (from propan-2-ol or *C6H6). [Bauer & Miarka J Org Chem 24 1293 1959, Fujino et al. Chem Pharm Bull Jpn 22 1857 1974]. [Beilstein 21/10 V 188.]

N-Hydroxy-5-norbornene-2,3-dicarboximide Preparation Products And Raw materials

Raw materials

Preparation Products

N-Hydroxy-5-norbornene-2,3-dicarboximide Suppliers

Global( 303)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Nanjing Triumpharm Co.,Ltd	+86-02586182925 +86-15105172550	info@triumpharm.com	China	129	58
Suzhou Highfine Biotech Co.,Ltd.	+86-0512-68071238 +86-13771819922	june@highfine.com	China	491	58
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	14034	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21531	55
AB PharmaTech,LLC	323-480-4688	sales@acrospharmatech.com	United States	988	55
Shanxi Naipu Import and Export Co.,Ltd	+86-13734021967 13734021967	kaia@neputrading.com	China	991	58
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29766	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10399	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8491	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63645	58

Supplier	Advantage
Nanjing Triumpharm Co.,Ltd	58
Suzhou Highfine Biotech Co.,Ltd.	58
Shanghai Daken Advanced Materials Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
AB PharmaTech,LLC	55
Shanxi Naipu Import and Export Co.,Ltd	58
career henan chemical co	58
Shenzhen Nexconn Pharmatechs Ltd	58
Jinan Carbotang Biotech Co.,Ltd.	58
Alchem Pharmtech,Inc.	58

View Lastest Price from N-Hydroxy-5-norbornene-2,3-dicarboximide manufacturers

Update time	Product	Min. Order	Purity	Supply Ability	Manufacturer
2026-06-30	N-Hydroxy-5-norbornene-2,3-dicarboximide 21715-90-2	1KG	98.0%	10000KGS	Shaanxi Dideu New Materials Co. Ltd
2026-03-31	N-Hydroxy-5-norbornene-2,3-dicarboximide 21715-90-2	1G	99.9%	20ton	Puyang Huicheng Electronic Materials Co., Ltd.
2025-04-04	N-Hydroxy-5-norbornene-2,3-dicarboximide 21715-90-2	1KG	98%	1ton	Henan Aochuang Chemical Co.,Ltd.

N-Hydroxy-5-norbornene-2,3-dicarboximide
21715-90-2
98.0%
Shaanxi Dideu New Materials Co. Ltd

N-Hydroxy-5-norbornene-2,3-dicarboximide
21715-90-2
99.9%
Puyang Huicheng Electronic Materials Co., Ltd.

N-Hydroxy-5-norbornene-2,3-dicarboximide
21715-90-2
98%
Henan Aochuang Chemical Co.,Ltd.

N-Hydroxy-5-norbornene-2,3-dicarboximide Spectrum

N-Hydroxy-5-norbornene-2,3-dicarboximide(21715-90-2)MS N-Hydroxy-5-norbornene-2,3-dicarboximide(21715-90-2)¹HNMR N-Hydroxy-5-norbornene-2,3-dicarboximide(21715-90-2)¹³CNMR N-Hydroxy-5-norbornene-2,3-dicarboximide(21715-90-2)IR1 N-Hydroxy-5-norbornene-2,3-dicarboximide(21715-90-2)IR2 N-Hydroxy-5-norbornene-2,3-dicarboximide(21715-90-2)Raman

21715-90-2(N-Hydroxy-5-norbornene-2,3-dicarboximide)Related Search:

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Norbornene 5-Norbornene-2,3-dicarboxylic acid 5-Norbornene-2-endo,3-exo-dicarboxylic acid EXO-NORBORNEOL 5-NORBORNENE-2,3-DICARBOXIMIDE

ENDO-N-HYDROXY-5-NORBORNENE-2,3-DICARBOXIMIDE, 97 N-BENZYLOXYCARBONYLOXY-5-NORBORNENE-2,3-DICARBOXIMIDE, 99 N-Hydroxy-5-norbornene-2,3-dicarboximide

1of4

N-HYDROXY-5-NORBORNENE-2,3-DICARBOXIMIDE N-HYDROXYBICYCLO[2.2.1]HEPT-5-ENE-2,3-DICARBOXYLIC ACID IMIDE N-HYDROXYBICYCLO[2.2.1]HEPT-5-ENE-2,3-DICARBOXIMIDE LABOTEST-BB LT00112336 3(2h)-dione,3a,4,7,7a-tetrahydro-2-hydroxy-7-methano-1h-isoindole-1 HONB, N-Hydroxybicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic acid imide 3a,4,7,7a-Tetrahydro-2-hydroxy-4,7-methano-1H-isoindole-1,3(2H)-dione 4-Hydroxy-4-azatricyclo[5.2.1.02,6]deca-8-ene-3,5-dione N-Hydroxybicyclo[2.2.1]hepta-5-ene-2,3-dicarbimide N-Hydroxynorborna-5-ene-2,3-dicarbimide N-Hydroxybicyclo[2.2.1]-5-heptene-2,3-dicarboxiMide N-Hydroxy-5-norborne 2-Hydroxy-3a,4,7,7a-tetrahydro-1H-4,7-Methanoisoindole-1,3(2H)-dione N-Hydroxy-5-norbornene-endo-2,3-dicarboximide97% N-Hydroxy-5-norbornene-2,4-dicarboximide N-Hydroxy-5-norbornene-2,3-dicarboxylic acid imide 97% N-hydroxy-5-norbornene-2.3-dicarboxylimide(HONB) N-Hydroxy-5-norbornene-2.3-dicarboxylic imide endo-N-Hydroxybicyclo[2.2.1]hept-5-ene-2,3-dicarbo Honb(N-Hydrozy-5-Norbornene-2.3-DicarboxylicImide) N-Hydroxy-5-Norborene-2,3-Dicarboximide N-Hydroxy-5-norbornene-2,3-dicarboximide, 99+% Endo-N-Hydroxy-5-Norbornene-2, HONB N-Hydroxy-5-norbornene-endo-2,3-dicarboximide N-Hydroxybicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic acid imide HONB, endo-N-Hydroxy-5-norbornene-2,3-dicarboximide ENDO-N-HYDROXY-5-NORBORNENE-2,3-DICARBOXIMIDE HONB N-HYDROXY-5-NORBORNENE-2,3-DICARBOXYLIC ACID IMIDE (HONB) N-hydroxynorborn-5-ene-2,3-dicarboximide N-Hydroxy-5-norbornene- 2,3-dicarboxylicacid imide,endo-N-Hydroxy-5- norbornene-2,3-dicarboximide N-HYDROXY-5-NORBONENE-2,3-DICARBOXYLIC IMIDE N-Hydroxy-5-norbornene-2,3-dicarboximide [for Peptide Synthesis] N-Hydroxy-5-norbornene-2,3-dicarboximide[forPeptideSynthesis]> N-Hydroxy-5-norbornene-2,3-dicarboximide USP/EP/BP TIANFU-CHEM 21715-90-2 N-Hydroxy-5-norbornene-2,3-dicarboximide 4-hydroxy-4-azatricyclo[5.2.1.02,]dec-8-ene-3,5-dione N-Hydroxy-5-Norbornene-2,3-dimethylimide N-Hydroxy-5-norbornene-2,3-dicarboxylic acid imide HONB N-HYDROXY-5-NORBORNENE-2.3-DICARBOXYLIMIDE HONB N-HYDROXY-5-NORBORNENE-2,3-DICARBOXYLIC ACID IMIDE N-HYDROXY-5-NORBORNENE-2,3-DICARBOXYLIMIDE N-HYDROXY-5-NORBORNENE-2,3-DICARBOXIMIDE (HONB) 21715-90-2 5C9H9NO3 Synthetic Reagents Coupling Coupling Reactions (Peptide Synthesis) Peptide Synthesis Condensation & Active Esterification Active Esters/Additives Coupling Reagent Medical Intermediates Biochemistry Condensation & Active Esterification Coupling Reactions (Peptide Synthesis) Peptide Synthesis Synthetic Organic Chemistry