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N-Hydroxy-5-norbornene-2,3-dicarboximide

N-Hydroxy-5-norbornene-2,3-dicarboximide Structure
N-Hydroxy-5-norbornene-2,3-dicarboximide structure
CAS No.
21715-90-2
Chemical Name:
N-Hydroxy-5-norbornene-2,3-dicarboximide
Synonyms
HONB;N-HYDROXY-5-NORBORNENE-2,3-DICARBOXYLIC ACID IMIDE;2-Hydroxy-3a,4,7,7a-tetrahydro-1H-4,7-Methanoisoindole-1,3(2H)-dione;N-Hydroxy-5-norborne;LABOTEST-BB LT00112336;Endo-N-Hydroxy-5-Norbornene-2,;N-Hydroxynorborna-5-ene-2,3-dicarbimide;N-Hydroxy-5-Norborene-2,3-Dicarboximide;N-HYDROXY-5-NORBORNENE-2,3-DICARBOXIMIDE;N-Hydroxy-5-norbornene-2,4-dicarboximide
CBNumber:
CB9121858
Molecular Formula:
C9H9NO3
Molecular Weight:
179.17
MDL Number:
MFCD00167583
MOL File:
21715-90-2.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-01-13 11:26:28
Product description Number Pack Size Price
N-Hydroxy-5-norbornene-2,3-dicarboxylic acid imide 97% 226378 50g $224
N-Hydroxy-5-norbornene-2,3-dicarboximide [for Peptide Synthesis] >99.0%(T) H0528 25g $31
N-Hydroxy-5-norbornene-2,3-dicarboximide [for Peptide Synthesis] >99.0%(T) H0528 250g $167
N-Hydroxy-5-norbornene-2,3-dicarboximide 279641 10g $305
HONB H669550 250g $250
More product size
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N-Hydroxy-5-norbornene-2,3-dicarboximide Properties

Melting point 165-170 °C (lit.)
Boiling point 311.69°C (rough estimate)
Density 1.2822 (rough estimate)
refractive index 1.5600 (estimate)
storage temp. Sealed in dry,2-8°C
solubility Soluble in ethanol
pka 9.00±0.20(Predicted)
form Solid
color Off-White
BRN 13540
InChI InChI=1S/C9H9NO3/c11-8-6-4-1-2-5(3-4)7(6)9(12)10(8)13/h1-2,4-7,13H,3H2
InChIKey ZUSSTQCWRDLYJA-UHFFFAOYSA-N
SMILES C1(=O)C2C(C3CC2C=C3)C(=O)N1O
CAS DataBase Reference 21715-90-2(CAS DataBase Reference)
EPA Substance Registry System 4,7-Methano-1H-isoindole-1,3(2H)-dione, 3a,4,7,7a-tetrahydro-2-hydroxy- (21715-90-2)
UNSPSC Code 12352300
NACRES NA.23

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3
TSCA  TSCA listed
HS Code  29280090
Storage Class 11 - Combustible Solids
NFPA 704
0
2 0

N-Hydroxy-5-norbornene-2,3-dicarboximide price More Price(34)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 226378 N-Hydroxy-5-norbornene-2,3-dicarboxylic acid imide 97% 21715-90-2 50g $224 2026-03-19 Buy
TCI Chemical H0528 N-Hydroxy-5-norbornene-2,3-dicarboximide [for Peptide Synthesis] >99.0%(T) 21715-90-2 25g $31 2026-03-19 Buy
TCI Chemical H0528 N-Hydroxy-5-norbornene-2,3-dicarboximide [for Peptide Synthesis] >99.0%(T) 21715-90-2 250g $167 2026-03-19 Buy
Usbiological 279641 N-Hydroxy-5-norbornene-2,3-dicarboximide 21715-90-2 10g $305 2021-12-16 Buy
TRC H669550 HONB 21715-90-2 250g $250 2021-12-16 Buy
Product number Packaging Price Buy
226378 50g $224 Buy
H0528 25g $31 Buy
H0528 250g $167 Buy
279641 10g $305 Buy
H669550 250g $250 Buy

N-Hydroxy-5-norbornene-2,3-dicarboximide Chemical Properties,Uses,Production

Description

N-Hydroxy-5-norbornene-2,3-dicarboximide (NHD) is a compound that has antiviral activity and is used to treat HIV infections. It inhibits the reverse transcriptase enzyme in the virus, which blocks the synthesis of viral DNA. The ferroelectric properties of NHD were first observed by observing changes in its melting point when mixed with water. This property makes it useful for diagnosis purposes. In animal studies, a dose of 5 mg/kg was found to be effective against cancer cells and the drug showed no toxicity in humans at doses up to 500 mg/day. The optimal reaction conditions for NHD are pH 6 and temperature 45 degrees Celsius.

Chemical Properties

white to off-white crystalline powder

Uses

N-Hydroxy-5-norbornene-2,3-dicarboximide(HONB) is used in solution-phase peptide synthesis. Used in the synthesis of enkephalin analogs.

Uses

Inhibits racemization in peptide synthesis using DCC as condensing agent.

Uses

It decreases racemization in peptide synthesis and inhibits formation of N-acylureas.

Purification Methods

Dissolve the imide in CHCl3, filter, evaporate and recrystallise from EtOAc. IR (nujol): max 1695, 1710 and 1770 (C=O), and 3100 (OH) cm-1. The O-acetyl derivative has m 113-114o (from EtOH) with IR bands at max 1730, 1770 and 1815 cm-1 only, and the O-benzoyl derivative has m 143-144o (from propan-2-ol or *C6H6). [Bauer & Miarka J Org Chem 24 1293 1959, Fujino et al. Chem Pharm Bull Jpn 22 1857 1974]. [Beilstein 21/10 V 188.]

N-Hydroxy-5-norbornene-2,3-dicarboximide Preparation Products And Raw materials

Raw materials

Preparation Products

N-Hydroxy-5-norbornene-2,3-dicarboximide Suppliers

Global( 302)Suppliers
Supplier Tel Email Country ProdList Advantage
Nanjing Triumpharm Co.,Ltd
+86-02586182925 +86-15105172550 info@triumpharm.com China 129 58
Suzhou Highfine Biotech Co.,Ltd.
+86-0512-68071238 +86-13771819922 june@highfine.com China 489 58
Shanghai Daken Advanced Materials Co.,Ltd 		+86-2158073036 info@dakenam.com China 13815 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21592 55
AB PharmaTech,LLC 		323-480-4688 sales@acrospharmatech.com United States 989 55
Shanxi Naipu Import and Export Co.,Ltd 		+86-13734021967 +8613734021967 kaia@neputrading.com China 1001 58
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29821 58
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715 admin@nexconn.com China 10404 58
Jinan Carbotang Biotech Co.,Ltd. 		+8615866703830 figo.gao@foxmail.com China 8497 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19552 58
Supplier Advantage
Nanjing Triumpharm Co.,Ltd
58
Suzhou Highfine Biotech Co.,Ltd.
58
Shanghai Daken Advanced Materials Co.,Ltd 		58
Henan Tianfu Chemical Co.,Ltd. 		55
AB PharmaTech,LLC 		55
Shanxi Naipu Import and Export Co.,Ltd 		58
career henan chemical co 		58
Shenzhen Nexconn Pharmatechs Ltd 		58
Jinan Carbotang Biotech Co.,Ltd. 		58
BOC Sciences 		58

View Lastest Price from N-Hydroxy-5-norbornene-2,3-dicarboximide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
N-Hydroxy-5-norbornene-2,3-dicarboximide pictures 2026-03-31 N-Hydroxy-5-norbornene-2,3-dicarboximide
21715-90-2
 US $0.00-0.00 / G 1G 99.9% 20ton Puyang Huicheng Electronic Materials Co., Ltd.
N-Hydroxy-5-norbornene-2,3-dicarboximide pictures 2025-12-01 N-Hydroxy-5-norbornene-2,3-dicarboximide
21715-90-2
 US $0.00-0.00 / KG 1KG 98.0% 10000KGS Shaanxi Dideu New Materials Co. Ltd
N-Hydroxy-5-norbornene-2,3-dicarboximide pictures 2025-04-04 N-Hydroxy-5-norbornene-2,3-dicarboximide
21715-90-2
 US $0.00-0.00 / KG 1KG 98% 1ton Henan Aochuang Chemical Co.,Ltd.

N-Hydroxy-5-norbornene-2,3-dicarboximide Spectrum

N-Hydroxy-5-norbornene-2,3-dicarboximide(21715-90-2)MSN-Hydroxy-5-norbornene-2,3-dicarboximide(21715-90-2)1HNMRN-Hydroxy-5-norbornene-2,3-dicarboximide(21715-90-2)13CNMRN-Hydroxy-5-norbornene-2,3-dicarboximide(21715-90-2)IR1N-Hydroxy-5-norbornene-2,3-dicarboximide(21715-90-2)IR2N-Hydroxy-5-norbornene-2,3-dicarboximide(21715-90-2)Raman

21715-90-2(N-Hydroxy-5-norbornene-2,3-dicarboximide)Related Search:

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ENDO-N-HYDROXY-5-NORBORNENE-2,3-DICARBOXIMIDE, 97 N-BENZYLOXYCARBONYLOXY-5-NORBORNENE-2,3-DICARBOXIMIDE, 99 N-Hydroxy-5-norbornene-2,3-dicarboximide

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N-HYDROXY-5-NORBORNENE-2,3-DICARBOXYLIC ACID IMIDE N-HYDROXY-5-NORBORNENE-2,3-DICARBOXYLIMIDE N-HYDROXY-5-NORBORNENE-2,3-DICARBOXIMIDE N-HYDROXYBICYCLO[2.2.1]HEPT-5-ENE-2,3-DICARBOXYLIC ACID IMIDE N-HYDROXYBICYCLO[2.2.1]HEPT-5-ENE-2,3-DICARBOXIMIDE LABOTEST-BB LT00112336 3(2h)-dione,3a,4,7,7a-tetrahydro-2-hydroxy-7-methano-1h-isoindole-1 HONB, N-Hydroxybicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic acid imide 3a,4,7,7a-Tetrahydro-2-hydroxy-4,7-methano-1H-isoindole-1,3(2H)-dione 4-Hydroxy-4-azatricyclo[5.2.1.02,6]deca-8-ene-3,5-dione N-Hydroxybicyclo[2.2.1]hepta-5-ene-2,3-dicarbimide N-Hydroxynorborna-5-ene-2,3-dicarbimide N-Hydroxybicyclo[2.2.1]-5-heptene-2,3-dicarboxiMide N-Hydroxy-5-norborne 2-Hydroxy-3a,4,7,7a-tetrahydro-1H-4,7-Methanoisoindole-1,3(2H)-dione N-Hydroxy-5-norbornene-endo-2,3-dicarboximide97% N-Hydroxy-5-norbornene-2,4-dicarboximide N-Hydroxy-5-norbornene-2,3-dicarboxylic acid imide 97% N-hydroxy-5-norbornene-2.3-dicarboxylimide(HONB) N-Hydroxy-5-norbornene-2.3-dicarboxylic imide endo-N-Hydroxybicyclo[2.2.1]hept-5-ene-2,3-dicarbo Honb(N-Hydrozy-5-Norbornene-2.3-DicarboxylicImide) N-Hydroxy-5-Norborene-2,3-Dicarboximide N-Hydroxy-5-norbornene-2,3-dicarboximide, 99+% Endo-N-Hydroxy-5-Norbornene-2, HONB N-Hydroxy-5-norbornene-endo-2,3-dicarboximide N-Hydroxybicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic acid imide HONB, endo-N-Hydroxy-5-norbornene-2,3-dicarboximide ENDO-N-HYDROXY-5-NORBORNENE-2,3-DICARBOXIMIDE HONB HONB N-HYDROXY-5-NORBORNENE-2.3-DICARBOXYLIMIDE N-HYDROXY-5-NORBORNENE-2,3-DICARBOXYLIC ACID IMIDE (HONB) N-hydroxynorborn-5-ene-2,3-dicarboximide N-Hydroxy-5-norbornene- 2,3-dicarboxylicacid imide,endo-N-Hydroxy-5- norbornene-2,3-dicarboximide N-HYDROXY-5-NORBORNENE-2,3-DICARBOXIMIDE (HONB) N-HYDROXY-5-NORBONENE-2,3-DICARBOXYLIC IMIDE N-Hydroxy-5-norbornene-2,3-dicarboximide [for Peptide Synthesis] N-Hydroxy-5-norbornene-2,3-dicarboximide[forPeptideSynthesis]> N-Hydroxy-5-norbornene-2,3-dicarboximide USP/EP/BP TIANFU-CHEM 21715-90-2 N-Hydroxy-5-norbornene-2,3-dicarboximide 4-hydroxy-4-azatricyclo[5.2.1.02,]dec-8-ene-3,5-dione N-Hydroxy-5-Norbornene-2,3-dimethylimide N-Hydroxy-5-norbornene-2,3-dicarboxylic acid imide HONB 21715-90-2 5C9H9NO3 Synthetic Reagents Coupling Coupling Reactions (Peptide Synthesis) Peptide Synthesis Condensation & Active Esterification Active Esters/Additives Coupling Reagent Medical Intermediates Biochemistry Condensation & Active Esterification Coupling Reactions (Peptide Synthesis) Peptide Synthesis Synthetic Organic Chemistry