HEMATOPORPHYRIN
- CAS No.
- 14459-29-1
- Chemical Name:
- HEMATOPORPHYRIN
- Synonyms
- hp;Ba1-647;Photodyn;NSC-59265;A-259H10.2;HEMATOPORPHYRIN;HAEMATOPORPHYRIN;HEMATOPORPHYRINE;hematoporphyrinix;HematoporphyrineBase
- CBNumber:
- CB9134564
- Molecular Formula:
- C34H38N4O6
- Molecular Weight:
- 598.69
- MDL Number:
- MFCD00005077
- MOL File:
- 14459-29-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| ANTI-HPR antibody produced in mouse purified immunoglobulin, buffered aqueous solution | SAB1411905 | 50 μg | $580 |
| HP | 356334 | 48Tests | $588 |
| HP | 356327 | 48Tests | $588 |
| HP | 356330 | 48Tests | $588 |
| HP | 383280 | 96Tests | $599 |
| More product size | |||
| Melting point | 172.5°C |
|---|---|
| Boiling point | 649.58°C (rough estimate) |
| Density | 1.328 |
| refractive index | 1.6000 (estimate) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | DMSO (Sparingly), Methanol (Slightly), Ethyl Acetate (Slightly) |
| form | Solid |
| color | Purple to Black |
| biological source | mouse |
| Merck | 13,4653 |
| Stability | Light Sensitive |
| SMILES | CC(O)c1c(C)c2cc3[nH]c(cc4nc(cc5[nH]c(cc1n2)c(C)c5CCC(O)=O)c(CCC(O)=O)c4C)c(C)c3C(C)O |
| FDA UNII | HBT6M5H379 |
| EPA Substance Registry System | 21H,23H-Porphine-2,18-dipropanoic acid, 7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl- (14459-29-1) |
| UNSPSC Code | 12352300 |
| NACRES | NA.41 |
HEMATOPORPHYRIN price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SAB1411905 | ANTI-HPR antibody produced in mouse purified immunoglobulin, buffered aqueous solution | 50 μg | $580 | 2026-04-30 | Buy | |
| Usbiological | 356334 | HP | 14459-29-1 | 48Tests | $588 | 2021-12-16 | Buy |
| Usbiological | 356327 | HP | 14459-29-1 | 48Tests | $588 | 2021-12-16 | Buy |
| Usbiological | 356330 | HP | 14459-29-1 | 48Tests | $588 | 2021-12-16 | Buy |
| Usbiological | 383280 | HP | 14459-29-1 | 96Tests | $599 | 2021-12-16 | Buy |
HEMATOPORPHYRIN Chemical Properties,Uses,Production
Chemical Properties
Red-purple crystals, soluble in ethanol, slightly soluble in ether and chloroform, insoluble in water.
Uses
antidepressant, antineoplastic
Uses
Hematoporphyrin (Photodyn, Sensibion) is a porphyrin prepared from hemin. It is a derivative of protoporphyrin IX, where the two vinyl groups have been hydrated (coverted to alcohols). It is used as a photosensitizer in photodynamic therapy. Acetylation of hematoporphyrin followed by hydrolysis of the product of that reaction affords a mixture called hematoporphyrin derivative (HPD), which is also used in photodynamic therapy. Hematoporphyrin has also been used as an antidepressant and antipsychotic since the 1920s.
Definition
ChEBI: A dicarboxylic acid that is protoporphyrin in which the vinyl groups at positions 7 and 12 are replaced by 1-hydroxyethyl groups.
Hazard
Toxic. Reported to be preferentially absorbed by cancerous tissues, making them fluoresce under UV light.
in vivo
Hematoporphyrin (5-10 mg/kg; i.p. for 2 months) with the irradiation of red light rapidly decreases the tumor size of rats, due to necrosis caused both by direct action of the photoactivated porphyrin on the tumor cells and by secondary effects on blood vessels[3].
| Animal Model: | Wistar albino rats of both sexes (20 d; 60-80 g) bearing a subcutaneous solid Yoshida hepatoma AH-130[3] |
| Dosage: | 5, 10 mg/kg |
| Administration: | I.p. daily during the initial 10 days and biweekly for the next 2 months |
| Result: | No tumor could be palpated a few days after exposure of the rats to light. The skin healed completely and regrowth of the hair occurred. Massive coagulation necrosis of the tumor 24 h after phototreatment (×40). |
IC 50
Human Endogenous Metabolite
Purification Methods
Purify it by dissolving it in EtOH Hematoporphyrin and adding H2O or Et2O to give deep red crystals. It has also been recrystallised from MeOH. UV has max at 615.5, 565, 534.4 and 499.5nm in 0.1N NaOH, and 597, 619, 634, 653, 683 and 701nm in 2N HCl [Falk Porphyrins and Metalloporphyrins Elsevier, NY, p 175 1964, LCCCNo 63-19821.] It is used in the affinity chromatographic purification of Heme proteins [Olsen Methods Enzymol 123 324 1986]. The O-methyl-dimethyl ester has m 203-206o (from CHCl3/MeOH), and the O,O'-dimethyl-dimethyl ester has m 145o (from CHCl3/MeOH). [Paul Acta Chem Scand 5 389 1951, Beilstein 26 III/IV 3157, and 3158 for the HCl.]
HEMATOPORPHYRIN Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| airuikechemical co., ltd. | +86-18353166132 | sales02@airuikechemical.com | China | 983 | 58 |
| Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 | admin@zlchemi.com | China | 3692 | 58 |
| ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | +86-13017695106 +86-13676922317 | jiuyitime@fdachem.com | China | 16513 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8615060885618 | sales@amoychem.com | China | 6369 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29794 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 9545 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32467 | 58 |
| Win-Win chemical CO., Limited | +86-0086-577-64498589 +86-15355981851 | sales@win-winchemical.com | China | 14304 | 58 |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | sales@afinechem.com | China | 15082 | 58 |
View Lastest Price from HEMATOPORPHYRIN manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-20 | Hematoporphyrin
14459-29-1
|
US $468.00 / mg | 10g | TargetMol Chemicals Inc. | |||
 |
2026-04-17 | Hematoporphyrin
14459-29-1
|
US $18.00-48.00 / KG | 0.01KG | 99% | g-kg-tons, free sample is available | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | |
 |
2025-04-15 | Hematoporphyrin
14459-29-1
|
US $60.00 / kg | 1kg | 99% | 5000kg/week | Hebei Zhuanglai Chemical Trading Co.,Ltd |
-
- Hematoporphyrin
14459-29-1
- US $468.00 / mg
- TargetMol Chemicals Inc.
-
- Hematoporphyrin
14459-29-1
- US $18.00-48.00 / KG
- 99%
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
-
- Hematoporphyrin
14459-29-1
- US $60.00 / kg
- 99%
- Hebei Zhuanglai Chemical Trading Co.,Ltd
