HEMATOPORPHYRIN

HEMATOPORPHYRIN 구조식 이미지
카스 번호:
14459-29-1
상품명:
HEMATOPORPHYRIN
동의어(영문):
hp;Ba1-647;Photodyn;NSC-59265;A-259H10.2;HEMATOPORPHYRIN;HAEMATOPORPHYRIN;HEMATOPORPHYRINE;hematoporphyrinix;HematoporphyrineBase
CBNumber:
CB9134564
분자식:
C34H38N4O6
포뮬러 무게:
598.69
MOL 파일:
14459-29-1.mol

HEMATOPORPHYRIN 속성

녹는점
172.5°C
끓는 점
649.58°C (rough estimate)
밀도
1.328
굴절률
1.6000 (estimate)
저장 조건
Sealed in dry,2-8°C
용해도
DMSO(소량으로 용해), 메탄올(약간 용해됨), 에틸아세테이트(약간 용해됨)
물리적 상태
고체
물리적 상태
단단한 모양
색상
보라색에서 검정색으로
생물학적 소스
mouse
Merck
13,4653
안정성
감광성
EPA
21H,23H-Porphine-2,18-dipropanoic acid, 7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl- (14459-29-1)

안전

안전지침서 22-24/25
WGK 독일 3
RTECS 번호 TS5500000
F 고인화성물질 8-10-21

HEMATOPORPHYRIN C화학적 특성, 용도, 생산

용도

Hematoporphyrin (Photodyn, Sensibion) is a porphyrin prepared from hemin. It is a derivative of protoporphyrin IX, where the two vinyl groups have been hydrated (coverted to alcohols). It is used as a photosensitizer in photodynamic therapy. Acetylation of hematoporphyrin followed by hydrolysis of the product of that reaction affords a mixture called hematoporphyrin derivative (HPD), which is also used in photodynamic therapy. Hematoporphyrin has also been used as an antidepressant and antipsychotic since the 1920s.

정의

ChEBI: A dicarboxylic acid that is protoporphyrin in which the vinyl groups at positions 7 and 12 are replaced by 1-hydroxyethyl groups.

위험도

Toxic. Reported to be preferentially absorbed by cancerous tissues, making them fluoresce under UV light.

Purification Methods

Purify it by dissolving it in EtOH Hematoporphyrin and adding H2O or Et2O to give deep red crystals. It has also been recrystallised from MeOH. UV has max at 615.5, 565, 534.4 and 499.5nm in 0.1N NaOH, and 597, 619, 634, 653, 683 and 701nm in 2N HCl [Falk Porphyrins and Metalloporphyrins Elsevier, NY, p 175 1964, LCCCNo 63-19821.] It is used in the affinity chromatographic purification of Heme proteins [Olsen Methods Enzymol 123 324 1986]. The O-methyl-dimethyl ester has m 203-206o (from CHCl3/MeOH), and the O,O'-dimethyl-dimethyl ester has m 145o (from CHCl3/MeOH). [Paul Acta Chem Scand 5 389 1951, Beilstein 26 III/IV 3157, and 3158 for the HCl.]

HEMATOPORPHYRIN 준비 용품 및 원자재

원자재

준비 용품


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