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Loxapine hydrochloride

Loxapine hydrochloride Structure
Loxapine hydrochloride structure
CAS No.
54810-23-0
Chemical Name:
Loxapine hydrochloride
Synonyms
Loxapine hydrochloride;8-chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzoxazepine,hydrochloride
CBNumber:
CB91485331
Molecular Formula:
C18H18ClN3O.ClH
Molecular Weight:
364.27
MDL Number:
MFCD00242836
MOL File:
54810-23-0.mol
MSDS File:
SDS
Last updated:2026-04-21 10:31:43
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Loxapine hydrochloride Properties

FDA UNII 376MYL4MAL

Loxapine hydrochloride Chemical Properties, Uses, Production

Uses

Loxapine hydrochloride is an orally active dopamine inhibitor, 5-HT receptor antagonist and also a dibenzoxazepine anti-psychotic agent[1][4].

in vivo

Loxapine (5 mg/kg; i.p.; daily for 4 or 10 weeks) decreases serotonin (S2) but does not elevate dopamine (D2) receptor numbers in the rat brain[3].

Animal Model:Adult male Wistar rats (150-175 g)[3]
Dosage:5 mg/kg
Administration:Intraperitoneal injection, daily for 4 or 10 weeks
Result:Induced a very significant reduction (more than 50%) of serotonin (S2) receptor density after 4 weeks or 10 weeks of daily injection, but did not produce any significant increase in dopamine receptor density.

IC 50

human 5-HT2; Human D4 Receptor; Human D1 Receptor; Human D2 Receptor

References

[1] Singh AN, et al. A neurochemical basis for the antipsychotic activity of loxapine: interactions with dopamine D1, D2, D4 and serotonin 5-HT2 receptor subtypes. J Psychiatry Neurosci. 1996 Jan;21(1):29-35. PMID:8580115
[2] Labuzek K, et al. Chlorpromazine and loxapine reduce interleukin-1beta and interleukin-2 release by rat mixed glial and microglial cell cultures. Eur Neuropsychopharmacol. 2005 Jan;15(1):23-30. DOI:10.1016/j.euroneuro.2004.04.002
[3] Lee T, et al. Loxapine and clozapine decrease serotonin (S2) but do not elevate dopamine (D2) receptor numbers in the rat brain. Psychiatry Res. 1984 Aug;12(4):277-85. DOI:10.1016/0165-1781(84)90044-1
[4] Keating GM. Loxapine inhalation powder: a review of its use in the acute treatment of agitation in patients with bipolar disorder or schizophrenia. CNS Drugs. 2013 Jun;27(6):479-89. DOI:10.1007/s40263-013-0075-9

Loxapine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Loxapine hydrochloride Suppliers

Global Suppliers ( 5)
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 4008200310 15002144251 marketing@tsbiochem.com China 24951 58
Chongqing jooe co., ltd +86-15223382610 info@jooe.com China 15930 58
TargetMol Chemicals Inc. 13564774135 marketing@targetmol.com United States 19950 58
Supplier Advantage
TargetMol Chemicals Inc. 58
Chongqing jooe co., ltd 58
TargetMol Chemicals Inc. 58

View Latest Price from Loxapine hydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Loxapine hydrochloride pictures 2026-04-20 Loxapine hydrochloride
54810-23-0
 $1520.00-2500.00 10g TargetMol Chemicals Inc.

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Loxapine hydrochloride 8-chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzoxazepine,hydrochloride 54810-23-0 C18H18ClN3OClH