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4-Chloro-2-methylthiopyrimidine

4-Chloro-2-methylthiopyrimidine Structure
4-Chloro-2-methylthiopyrimidine structure
CAS No.
49844-90-8
Chemical Name:
4-Chloro-2-methylthiopyrimidine
Synonyms
4-CHLORO-2-(METHYLTHIO)PYRIMIDINE;4-CHLORO-2-METHYLSULFANYL-PYRIMIDINE;PYRIMIDINE, 4-CHLORO-2-(METHYLTHIO)-;4-Chloro-2-(methylthio)pyrimidine 97%;4-Chloro-2-(Methylthio)py...;2-methylthio-4-chloropyrimine;6-Chloro-2-methylthiopyrimidine;2-(Methylthio)-4-chloropyrimidine;4-Chloro-2-methylthiopyrimidine,97%;4-Chloro-2-(methylmercapto)pyrimidine
CBNumber:
CB9149799
Molecular Formula:
C5H5ClN2S
Molecular Weight:
160.62
MDL Number:
MFCD00006083
MOL File:
49844-90-8.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 05:49:05
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4-Chloro-2-methylthiopyrimidine Properties

Melting point −2 °C(lit.)
Boiling point 139-140 °C36 mm Hg(lit.)
Density 1.381 g/mL at 25 °C(lit.)
refractive index n20/D 1.6(lit.)
Flash point >230 °F
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
form liquid
pka -0.56±0.20(Predicted)
color Colorless to Red to Green
Water Solubility Not miscible or difficult to mix in water.
Sensitive Hygroscopic
BRN 118042
InChI InChI=1S/C5H5ClN2S/c1-9-5-7-3-2-4(6)8-5/h2-3H,1H3
InChIKey DFOHHQRGDOQMKG-UHFFFAOYSA-N
SMILES C1(SC)=NC=CC(Cl)=N1
CAS DataBase Reference 49844-90-8(CAS DataBase Reference)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)
GHS05
Signal word  Danger
Hazard statements  H314
Precautionary statements  P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363-P405
PPE Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
Hazard Codes  C
Risk Statements  34
Safety Statements  26-36/37/39-45
RIDADR  UN 1760 8/PG 2
WGK Germany  3
F  10-13-23
Hazard Note  Corrosive/Hygroscopic
HazardClass  8
PackingGroup  III
HS Code  29335990
Storage Class 8A - Combustible corrosive hazardous materials
Hazard Classifications Skin Corr. 1B
Limited Quantities 1.0 L (0.3 gallons) (liquid) or 1 Kg (2.2 lbs) (solid)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml)
NFPA 704
1
3 1

4-Chloro-2-methylthiopyrimidine price More Price(54)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 145289 4-Chloro-2-methylthiopyrimidine 98% 49844-90-8 10g $56 2026-04-30 Buy
Sigma-Aldrich 145289 4-Chloro-2-methylthiopyrimidine 98% 49844-90-8 50g $265 2026-04-30 Buy
TCI Chemical C3087 4-Chloro-2-(methylthio)pyrimidine >98.0%(GC) 49844-90-8 5g $47 2026-04-30 Buy
TCI Chemical C3087 4-Chloro-2-(methylthio)pyrimidine >98.0%(GC) 49844-90-8 25g $141 2026-04-30 Buy
AstaTech 63254 4-CHLORO-2-METHYLSULFANYLPYRIMIDINE 95% 49844-90-8 25G $55 2026-04-30 Buy
Product number Packaging Price Buy
145289 10g $56 Buy
145289 50g $265 Buy
C3087 5g $47 Buy
C3087 25g $141 Buy
63254 25G $55 Buy

4-Chloro-2-methylthiopyrimidine Chemical Properties, Uses, Production

Chemical Properties

Clear yellow to brown liquid

Uses

It finds it application as a building block used in medicinal chemistry synthesis. 4-Chloro-2-methylthiopyrimidine is used in the total synthesis of the marine alkaloid variolin B1 and 2-hydroxy-4-pyrimidinecarboxylic acid. It is also used in the synthesis of 2,4-disubstituted pyrimidines, a novel class of KDR kinase inhibitors.

Uses

4-Chloro-2-methylthiopyrimidine was used in the total synthesis of the marine alkaloid variolin B1 and 2-hydroxy-4-pyrimidinecarboxylic acid. It was used in the synthesis of 2,4-disubstituted pyrimidines, a novel class of KDR kinase inhibitors. It was used as building block in medicinal chemistry synthesis.

Synthesis

4-Chloro-2-methylthiopyrimidine can be produced from 2-thiouracil as raw material, dimethyl sulfate as methylation reagent, and thionyl chloride and phosphorus oxychloride as chlorination reagents by methylation and chlorination reaction.

4-Chloro-2-methylthiopyrimidine synthesis

5751-20-2
49844-90-8
Synthesis of 4-Chloro-2-methylthiopyrimidine from 2-Methylthio-4-pyrimidinol

4-Chloro-2-methylthiopyrimidine Preparation Products And Raw materials

Raw materials

Phosphorus oxitrichloride 2-Thiouracil 2-Methylthio-4-pyrimidinol Iodomethane

Preparation Products

4-Chloro-2-(methylthio)pyrimidine-5-carboxaldehyde 2-Methylthio-4-bromopyrimidine 4-Hydrazino-2-(methylsulfanyl)pyrimidine 2-(methylthio)-4-(1H-pyrazol-4-yl)pyrimidine 4-Chloro-2-(methylsulfonyl)pyrimidine

4-Chloro-2-methylthiopyrimidine Suppliers

Global Suppliers ( 296)
Supplier Tel Email Country ProdList Advantage
Changzhou Qinuo Chemical Co., Ltd.Co., Ltd. 0519-0519-83812535 sales@qinuochem.com China 287 60
Xi'an Yutebang New Material Technology Co., Ltd. 029-84536388 19991842844 ella@yutbon.com China 155 58
Shandong Chenyi Environmental Protection Technology Co., Ltd 0531-83179999 13395316108 cyhbkjyxgs@163.com China 196 58
Nanbu County Chengxin Technology Co., Ltd. 0838-5675166 15883665058 nbcxkj@126.com China 956 55
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Supplier Advantage
Changzhou Qinuo Chemical Co., Ltd.Co., Ltd. 60
Xi'an Yutebang New Material Technology Co., Ltd. 58
Shandong Chenyi Environmental Protection Technology Co., Ltd 58
Nanbu County Chengxin Technology Co., Ltd. 55
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61
Capot Chemical Co., Ltd 66

View Latest Price from 4-Chloro-2-methylthiopyrimidine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-Chloro-2-methylthiopyrimidine pictures 2026-06-30 4-Chloro-2-methylthiopyrimidine
49844-90-8
 1kg 99% 10000KGS Shaanxi Dideu New Materials Co. Ltd
4-Chloro-2-methylthiopyrimidine pictures 2026-06-08 4-Chloro-2-methylthiopyrimidine
49844-90-8
 1kg 99% 1 Jinan Ruitong Biotech Co., Ltd.
4-Chloro-2-methylthiopyrimidine pictures 2025-05-23 4-Chloro-2-methylthiopyrimidine
49844-90-8
 $50.00 1kg 99 5000 Hebei Zhuanglai Chemical Trading Co Ltd

4-Chloro-2-methylthiopyrimidine Spectrum

4-Chloro-2-methylthiopyrimidine(49844-90-8)1HNMR4-Chloro-2-methylthiopyrimidine(49844-90-8)FT-IR4-Chloro-2-methylthiopyrimidine(49844-90-8)IR4-Chloro-2-methylthiopyrimidine(49844-90-8)Raman

49844-90-8 (4-Chloro-2-methylthiopyrimidine) Related Search:

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4-Chloro-2-(methylmercapto)pyrimidine 4-Chloro-2-(methylsulphanyl)pyrimidine 97% 4-CHLORO-2-METHYLSULFANYL-PYRIMIDINE 2-methylthio-4-chloropyrimine 2-(Methylthio)-4-chloropyrimidine 4-Chloro-2-(methylthio)pyrimidine ,98% 4-Chloro-2-(Methylthio)py... 4-Chloro-2-(methylmercapto)pyrimidine, 4-Chloro-2-(methylsulphanyl)pyrimidine 4-Chloro-2-methylthiopyrimidine,97% 4-Chloro-2-methylthiopyrimidine 4-Chloro-2-(methylthio)pyrimidine 6-Chloro-2-methylthiopyrimidine 4-Chloro-2-methylthiopyrimidine≥ 99% (GC) 4-Chloro-2-(methylsulphanyl)pyrimidine 4-Chloro-2-(methylthio)pyrimidine 97% 4-CHLORO-2-(METHYLTHIO)PYRIMIDINE PYRIMIDINE, 4-CHLORO-2-(METHYLTHIO)- 49844-90-8 C5H5ClN2S Building Blocks Heterocyclic Building Blocks Halogenated Heterocycles Pyrimidines Pyrazines, Pyrimidines & Pyridazines Building Blocks Halogenated Heterocycles Heterocyclic Building Blocks Pyrimidines PyrimidinesHeterocyclic Building Blocks Pyrimidine Halides Pyrazines, Pyrimidines & Pyridazines Heterocycle-Pyrimidine series