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4-Chloro-2-methylthiopyrimidine

4-Chloro-2-methylthiopyrimidine Structure
4-Chloro-2-methylthiopyrimidine structure
CAS No.
49844-90-8
Chemical Name:
4-Chloro-2-methylthiopyrimidine
Synonyms
4-CHLORO-2-(METHYLTHIO)PYRIMIDINE;4-CHLORO-2-METHYLSULFANYL-PYRIMIDINE;4-Chloro-2-(Methylthio)py...;2-methylthio-4-chloropyrimine;6-Chloro-2-methylthiopyrimidine;2-(Methylthio)-4-chloropyrimidine;4-Chloro-2-methylthiopyrimidine,97%;PYRIMIDINE, 4-CHLORO-2-(METHYLTHIO)-;4-Chloro-2-(methylthio)pyrimidine 97%;4-Chloro-2-(methylmercapto)pyrimidine
CBNumber:
CB9149799
Molecular Formula:
C5H5ClN2S
Molecular Weight:
160.62
MDL Number:
MFCD00006083
MOL File:
49844-90-8.mol
MSDS File:
SDS
Last updated:2026-01-13 11:26:38
Product description Number Pack Size Price
4-Chloro-2-methylthiopyrimidine 98% 145289 10g $56
4-Chloro-2-methylthiopyrimidine 98% 145289 50g $265
4-Chloro-2-(methylthio)pyrimidine >98.0%(GC) C3087 5g $47
4-Chloro-2-(methylthio)pyrimidine >98.0%(GC) C3087 25g $141
4-Chloro-2-(methylthio)pyrimidine C993410 1g $45
More product size
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4-Chloro-2-methylthiopyrimidine Properties

Melting point −2 °C(lit.)
Boiling point 139-140 °C36 mm Hg(lit.)
Density 1.381 g/mL at 25 °C(lit.)
refractive index n20/D 1.6(lit.)
Flash point >230 °F
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
pka -0.56±0.20(Predicted)
form liquid
color Colorless to Red to Green
Water Solubility Not miscible or difficult to mix in water.
Sensitive Hygroscopic
BRN 118042
InChI InChI=1S/C5H5ClN2S/c1-9-5-7-3-2-4(6)8-5/h2-3H,1H3
InChIKey DFOHHQRGDOQMKG-UHFFFAOYSA-N
SMILES C1(SC)=NC=CC(Cl)=N1
CAS DataBase Reference 49844-90-8(CAS DataBase Reference)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS05
Signal word  Danger
Hazard statements  H314
Precautionary statements  P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363-P405
PPE Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
Hazard Codes  C
Risk Statements  34
Safety Statements  26-36/37/39-45
RIDADR  UN 1760 8/PG 2
WGK Germany  3
F  10-13-23
Hazard Note  Corrosive/Hygroscopic
HazardClass  8
PackingGroup  III
HS Code  29335990
Storage Class 8A - Combustible corrosive hazardous materials
Hazard Classifications Skin Corr. 1B
Limited Quantities 1.0 L (0.3 gallons) (liquid) or 1 Kg (2.2 lbs) (solid)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml)
NFPA 704
1
3 1

4-Chloro-2-methylthiopyrimidine price More Price(29)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 145289 4-Chloro-2-methylthiopyrimidine 98% 49844-90-8 10g $56 2026-03-19 Buy
Sigma-Aldrich 145289 4-Chloro-2-methylthiopyrimidine 98% 49844-90-8 50g $265 2026-03-19 Buy
TCI Chemical C3087 4-Chloro-2-(methylthio)pyrimidine >98.0%(GC) 49844-90-8 5g $47 2026-03-19 Buy
TCI Chemical C3087 4-Chloro-2-(methylthio)pyrimidine >98.0%(GC) 49844-90-8 25g $141 2026-03-19 Buy
TRC C993410 4-Chloro-2-(methylthio)pyrimidine 49844-90-8 1g $45 2021-12-16 Buy
Product number Packaging Price Buy
145289 10g $56 Buy
145289 50g $265 Buy
C3087 5g $47 Buy
C3087 25g $141 Buy
C993410 1g $45 Buy

4-Chloro-2-methylthiopyrimidine Chemical Properties,Uses,Production

Chemical Properties

Clear yellow to brown liquid

Uses

It finds it application as a building block used in medicinal chemistry synthesis. 4-Chloro-2-methylthiopyrimidine is used in the total synthesis of the marine alkaloid variolin B1 and 2-hydroxy-4-pyrimidinecarboxylic acid. It is also used in the synthesis of 2,4-disubstituted pyrimidines, a novel class of KDR kinase inhibitors.

Uses

4-Chloro-2-methylthiopyrimidine was used in the total synthesis of the marine alkaloid variolin B1 and 2-hydroxy-4-pyrimidinecarboxylic acid. It was used in the synthesis of 2,4-disubstituted pyrimidines, a novel class of KDR kinase inhibitors. It was used as building block in medicinal chemistry synthesis.

Synthesis

4-Chloro-2-methylthiopyrimidine can be produced from 2-thiouracil as raw material, dimethyl sulfate as methylation reagent, and thionyl chloride and phosphorus oxychloride as chlorination reagents by methylation and chlorination reaction.

4-Chloro-2-methylthiopyrimidine synthesis

5751-20-2
49844-90-8
Synthesis of 4-Chloro-2-methylthiopyrimidine from 2-Methylthio-4-pyrimidinol

4-Chloro-2-methylthiopyrimidine Preparation Products And Raw materials

Raw materials

Phosphorus oxitrichloride 2-Thiouracil 2-Methylthio-4-pyrimidinol Iodomethane

Preparation Products

4-Chloro-2-(methylthio)pyrimidine-5-carboxaldehyde 2-METHYLTHIO-4-BROMOPYRIMIDINE 4-Hydrazino-2-(methylsulfanyl)pyrimidine 2-(methylthio)-4-(1H-pyrazol-4-yl)pyrimidine 4-Chloro-2-(methylsulfonyl)pyrimidine

4-Chloro-2-methylthiopyrimidine Suppliers

Global( 293)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29640 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-2158073036 info@dakenam.com China 13815 58
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
Changzhou Ansciep Chemical Co., Ltd. 		+86 519 86305871 sales@ansciepchem.com CHINA 4241 58
HaBo Hong Kong Co., Limited. 		+86-25-18512596065 info@habotech.com CHINA 933 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49977 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29795 58
Shaanxi Dideu Medichem Co. Ltd 		+86-029-81138252 +86-173 9270 1263 1057@dideu.com China 4000 58
Antai Fine Chemical Technology Co.,Limited 		18503026267 info@antaichem.com CHINA 9636 58
Supplier Advantage
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58
ATK CHEMICAL COMPANY LIMITED 		60
Changzhou Ansciep Chemical Co., Ltd. 		58
HaBo Hong Kong Co., Limited. 		58
Alchem Pharmtech,Inc. 		58
CONIER CHEM AND PHARMA LIMITED 		58
career henan chemical co 		58
Shaanxi Dideu Medichem Co. Ltd 		58
Antai Fine Chemical Technology Co.,Limited 		58

View Lastest Price from 4-Chloro-2-methylthiopyrimidine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-Chloro-2-methylthiopyrimidine pictures 2025-12-01 4-Chloro-2-methylthiopyrimidine
49844-90-8
 US $0.00 / kg 1kg 99% 10000KGS Shaanxi Dideu New Materials Co. Ltd
4-Chloro-2-methylthiopyrimidine pictures 2025-08-29 4-Chloro-2-methylthiopyrimidine
49844-90-8
 US $0.00-0.00 / kg 1kg 99% 1 Jinan Ruitong Biotech Co., Ltd.
4-Chloro-2-methylthiopyrimidine pictures 2025-05-23 4-Chloro-2-methylthiopyrimidine
49844-90-8
 US $50.00 / kg 1kg 99 5000 Hebei Zhuanglai Chemical Trading Co Ltd

4-Chloro-2-methylthiopyrimidine Spectrum

4-Chloro-2-methylthiopyrimidine(49844-90-8)1HNMR4-Chloro-2-methylthiopyrimidine(49844-90-8)FT-IR4-Chloro-2-methylthiopyrimidine(49844-90-8)IR4-Chloro-2-methylthiopyrimidine(49844-90-8)Raman

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4-Chloro-2-(methylmercapto)pyrimidine 4-Chloro-2-(methylsulphanyl)pyrimidine 97% 4-CHLORO-2-METHYLSULFANYL-PYRIMIDINE 4-Chloro-2-(methylthio)pyrimidine 97% 2-methylthio-4-chloropyrimine 2-(Methylthio)-4-chloropyrimidine 4-Chloro-2-(methylthio)pyrimidine ,98% 4-Chloro-2-(Methylthio)py... 4-Chloro-2-(methylmercapto)pyrimidine, 4-Chloro-2-(methylsulphanyl)pyrimidine 4-Chloro-2-methylthiopyrimidine,97% 4-Chloro-2-methylthiopyrimidine 4-Chloro-2-(methylthio)pyrimidine 6-Chloro-2-methylthiopyrimidine 4-Chloro-2-methylthiopyrimidine≥ 99% (GC) PYRIMIDINE, 4-CHLORO-2-(METHYLTHIO)- 4-CHLORO-2-(METHYLTHIO)PYRIMIDINE 4-Chloro-2-(methylsulphanyl)pyrimidine 49844-90-8 C5H5ClN2S Building Blocks Heterocyclic Building Blocks Halogenated Heterocycles Pyrimidines Pyrazines, Pyrimidines & Pyridazines Building Blocks Halogenated Heterocycles Heterocyclic Building Blocks Pyrimidines PyrimidinesHeterocyclic Building Blocks Pyrimidine Halides Pyrazines, Pyrimidines & Pyridazines Heterocycle-Pyrimidine series