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2-Thiouracil

CAS No.
141-90-2
Chemical Name:
2-Thiouracil
Synonyms
TU;2-thioxo-2,3-dihydropyriMidin-4(1H)-one;Thiouracil;2-TU;Nobilen;DERACIL;Thiouraci;tiouracyl;THIURACIL;NSC 19473
CBNumber:
CB5769908
Molecular Formula:
C4H4N2OS
Molecular Weight:
128.15
MDL Number:
MFCD00006039
MOL File:
141-90-2.mol
MSDS File:
SDS
Last updated:2026-04-14 09:55:04
Product description Number Pack Size Price
2-Thiouracil ≥99% T7750 25g $67.6
2-Thiouracil ≥99% T7750 1kg $887
2-Thiouracil for synthesis 8.21120 100G $73.7
2-Thiouracil for synthesis 8.21120 500G $328
2-Thiouracil for synthesis 8.21120 1KG $579
More product size

2-Thiouracil Properties

Melting point >300 °C (lit.)
bulk density 600kg/m3
Density 1.368 (estimate)
refractive index 1.7000 (estimate)
storage temp. Store below +30°C.
solubility 7.9g/l
pka pKa 7.46 (Uncertain)
form Fine Crystalline Powder
color White to cream
biological source synthetic
Water Solubility 0.5 g/L
λmax 271nm(H2O)(lit.)
Merck 14,9366
BRN 112227
InChI 1S/C4H4N2OS/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8)
InChIKey ZEMGGZBWXRYJHK-UHFFFAOYSA-N
SMILES O=C1NC(=S)NC=C1
CAS DataBase Reference 141-90-2(CAS DataBase Reference)
EWG's Food Scores 2
FDA UNII 59X161SCYL
IARC 2B (Vol. Sup 7, 79) 2001
NIST Chemistry Reference 2-Thiouracil(141-90-2)
Proposition 65 List Thiouracil
EPA Substance Registry System Thiouracil (141-90-2)
UNSPSC Code 41106305
NACRES NA.51

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS08
Signal word  Warning
Hazard statements  H351
Precautionary statements  P281
PPE Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
Hazard Codes  Xn,T
Risk Statements  40-45-20/21/22
Safety Statements  36/37-53-45
WGK Germany  3
RTECS  YR1575000
Autoignition Temperature 570°C
TSCA  TSCA listed
HS Code  29335995
Storage Class 11 - Combustible Solids
Hazard Classifications Carc. 2
Hazardous Substances Data 141-90-2(Hazardous Substances Data)
NFPA 704
0
1 0

2-Thiouracil price More Price(33)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich T7750 2-Thiouracil ≥99% 141-90-2 25g $67.6 2026-03-19 Buy
Sigma-Aldrich T7750 2-Thiouracil ≥99% 141-90-2 1kg $887 2026-03-19 Buy
Sigma-Aldrich 8.21120 2-Thiouracil for synthesis 141-90-2 100G $73.7 2026-03-19 Buy
Sigma-Aldrich 8.21120 2-Thiouracil for synthesis 141-90-2 500G $328 2026-03-19 Buy
Sigma-Aldrich 8.21120 2-Thiouracil for synthesis 141-90-2 1KG $579 2026-03-19 Buy
Product number Packaging Price Buy
T7750 25g $67.6 Buy
T7750 1kg $887 Buy
8.21120 100G $73.7 Buy
8.21120 500G $328 Buy
8.21120 1KG $579 Buy

2-Thiouracil Chemical Properties,Uses,Production

Chemical Properties

white to cream fine crystalline powder

Uses

Reagent used in the preparation of Antithyroid agents.

Uses

antiviral, thyroid depressant

Uses

2-Thiouracil has been used in the synthesis and characterization of silver colloid and film substrates and their applications in surface-enhanced Raman scattering (SERS)

Definition

ChEBI: A nucleobase analogue that is uracil in which the oxo group at C-2 is replaced by a thioxo group.

Biochem/physiol Actions

2-Thiouracil is a thio-derivative of uracil, a pyrimidine nucleobase. It acts as an anticancer, antithyroid, and antiviral agent. 2-Thiouracil is a selective melanoma-seeker and competitive inhibitor of neuronal nitric oxide synthase. It also forms complexes with transition metals such as gold (Au), Chromium (Cr), Zinc (Zn), and Silver (Ag).

Safety Profile

Moderately toxic by ingestion. Human teratogenic effects by unspecified routes: developmental abnormalities of the central nervous system, craniofacial area, and endocrine system. Human reproductive effects by unspecified route: effects on newborn, including viabllity index changes. Experimental teratogenic effects. Other experimental reproductive effects. Questionable carcinogen with experimental neoplastigenic and tumorigenic data. Mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and SOx. Used in the treatment of hyperthyroidism, angina pectoris, and congestive heart failure. See also MERCAPTANS and KETONES.

Purification Methods

Crystallise 2-thiouracil from water or EtOH. [Beilstein 24 H 323, 24 I 315, 24 II 171, 24 III/IV 1237.]

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View Lastest Price from 2-Thiouracil manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Thiouracil pictures 2026-04-20 2-Thiouracil
141-90-2
US $99.00-66.00 / kg 0.0010000000474974513kg 99% 5000 HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
2-Thiouracil pictures 2026-04-16 2-Thiouracil
141-90-2
US $0.00-0.00 / Kg 1Kg 98% 20Ton Xinxiang Aurora Biotechnology Co.,Ltd.
2-Thiouracil pictures 2026-04-14 2-Thiouracil
141-90-2
US $29.00 / g 99.89% 10g TargetMol Chemicals Inc.
  • 2-Thiouracil pictures
  • 2-Thiouracil
    141-90-2
  • US $99.00-66.00 / kg
  • 99%
  • HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
  • 2-Thiouracil pictures
  • 2-Thiouracil
    141-90-2
  • US $0.00-0.00 / Kg
  • 98%
  • Xinxiang Aurora Biotechnology Co.,Ltd.
  • 2-Thiouracil pictures
  • 2-Thiouracil
    141-90-2
  • US $29.00 / g
  • 99.89%
  • TargetMol Chemicals Inc.
2-Thiouracil Vetec(TM) reagent grade, 99% 2-ThiouraCll 4-HYDROXY-2-MERCAPTOPYRIMIDINE 4-HYDROXY-2-THIOPYRIMIDINE 2-MERCAPTO-4-PYRIMIDONE 2-MERCAPTO-4-HYDROXYPYRIMIDINE 2-thio-uraci 2-TU 4(1H)-Pyrimidinone, 2,3-dihydro-2-thioxo- 4(1H)-Pyrimidinone,2,3-dihydro-2-thioxo- 4-hydroxy-2(1h)-pyrimidinethione 4-Hydroxy-2-pyrimidinethiol 4-Pyrimidinol, 2-mercapto- 6-Hydroxy-2-mercaptopyrimidine 6-Thiouracil Antagothyroid Antagothyroil nci-c01490 Nobilen Thiouraci tiouracyl NSC 290412 NSC 290413 NSC 290414 2-Mercapto-4-hydroxypyrimidine 2-Mercapto-4-pyrimidone 2-THIOURACIL 2,3-dihydro-2-thioxo-4(1h)-pyrimidinone DERACIL 2,3-dihydro-2-thioxo-4(1h)-pyrimidinon Thiourea pyriMidine 2-Thiouracil, TU 2-mercapto-4(1h)-pyrimidinone 2-mercapto-4-pyrimidino 2-Mercapto-4-pyrimidinol 2-Mercaptopyrimid-4-one 2-Sulfanyl-4-pyrimidinol 2-Thio-1,3-pyrimidin-4-one 2-thio-2,4-(1h,3h)-pyrimidinedione 2-thio-4-oxo-1,3-pyrimidine 2-thio-4-oxypyrimidine 2-thio-6-oxypyrimidine Uracil, 2-thio- 4-HYDROXY-2-MERCAPTOPYRIMIDINE / 2-THIOURACIL 2-THIO-URACYLE THIURACIL 2-THIOURACIL VETRANAL, 250 MG 2-ThiouracilForSynthesis 2-Thiouracil, 98+% 4(1H)-Pyrimidinone, 2,3-dihydro-2-thioxo- (9CI) 2-HYDROXY-2-MERCAPTOPYRIMIDINE 2-THIOURACIL extrapure 2-Sulfanylidene-1H-pyrimidin-4-one 2-Thiouracil ,99% 2-Thioxo-2,3-dihydro-1H-pyrimidin-4-one 2-sulfanylidene-1,2,3,4-tetrahydropyriMidin-4-one 2-Mercapto-4-pyriMidinone NSC 19473 2-THIOURACIL, [4-HYDROXY-2-MERCAPTOPYRIMIDINE]