Octanohydroxamic Acid
- CAS No.
- 7377-03-9
- Chemical Name:
- Octanohydroxamic Acid
- Synonyms
- CaprylhydroxaMic Acid;OCTANOHYDROXAMIC ACID;CAPRYLHYDROXAMIC;CAPRYLOHYDROXAMIC ACID;hydroximic acid;taselin;n-hydroxy-octanamid;N-HYDROXYOCTANAMIDE;OctanaMide, N-hydroxy-;HOHA
- CBNumber:
- CB9150582
- Molecular Formula:
- C8H17NO2
- Molecular Weight:
- 159.23
- MDL Number:
- MFCD00143918
- MOL File:
- 7377-03-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 78°C |
|---|---|
| Density | 0.970 |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 9.56±0.20(Predicted) |
| color | White to Off-White |
| Cosmetics Ingredients Functions | CHELATING |
| Cosmetic Ingredient Review (CIR) | Octanohydroxamic Acid (7377-03-9) |
| InChI | InChI=1S/C8H17NO2/c1-2-3-4-5-6-7-8(10)9-11/h11H,2-7H2,1H3,(H,9,10) |
| InChIKey | RGUVUPQQFXCJFC-UHFFFAOYSA-N |
| SMILES | C(NO)(=O)CCCCCCC |
| EWG's Food Scores | 1 |
| FDA UNII | UPY805K99W |
| EPA Substance Registry System | Octanamide, N-hydroxy- (7377-03-9) |
| UNSPSC Code | 12352111 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H319-H335-H315 |
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362 |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36/37/39 |
| WGK Germany | WGK 3 |
| RTECS | RG9900500 |
| TSCA | TSCA listed |
| HS Code | 2928.00.5000 |
| Storage Class | 11 - Combustible Solids |
| REACH Registrations | Active |
Octanohydroxamic Acid price More Price(44)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | C1232 | Octanohydroxamic Acid >99.0%(N) | 7377-03-9 | 5g | $80 | 2026-04-30 | Buy |
| TCI Chemical | C1232 | Octanohydroxamic Acid >99.0%(N) | 7377-03-9 | 25g | $239 | 2026-04-30 | Buy |
| Biosynth | FC28962 | Caprylohydroxamic acid | 7377-03-9 | 50g | $201 | 2026-06-04 | Buy |
| Biosynth | FC28962 | Caprylohydroxamic acid | 7377-03-9 | 100g | $312 | 2026-06-04 | Buy |
| Biosynth | FC28962 | Caprylohydroxamic acid | 7377-03-9 | 250g | $612.5 | 2026-06-04 | Buy |
Octanohydroxamic Acid Chemical Properties, Uses, Production
Description
Octanohydroxamic acid (OHA), the more common hydroxamate collector, has both an acid group (single bondNHOH) and basic group (single bond CO). The hydrogen in the acid group can be replaced by a metal ion and a dative bond from the basic group to form a chelate. Improved monazite flotation performance was reported when using OHA compared to the results obtained with sodium oleate. Flotation separation of monazite and calcite using OHA has been described in previous publications. OHA was the most potent urease inhibitor among saturated hydroxamic acid (HAs) with a calculated IC50 of 0.25±0.1mM compared to 8.67±1.3 and 0.50±0.2mM for Acetohydroxamic acid and heptanohydroxamic acid, respectively. Further increase in the chain length from 8 to 12 carbons negatively affected the potency of HAs[1].
Uses
Octanohydroxamic Acid is used in preparation of Caprylohydroxamic Acid.
Synthesis
106-32-1
7377-03-9
To a 1000 mL four-necked flask was added hydroxylamine hydrochloride (48.7 g, 0.70 mol, 1.4 eq.), water (50 g), and ethanol (200 g, 2.3 times the volume), and stirred at room temperature until hydroxylamine hydrochloride was completely dissolved. Ethyl octanoate (86.7 g, 0.5 mol, 1.0 eq.) was then added and stirred at room temperature to form a two-phase system. The reaction mixture was cooled to 5-10°C and 40% KOH solution (168 g, 1.2 mol, 2.4 eq.) was added slowly and dropwise. After the dropwise addition, the reaction system was heated to 50~55°C and the reaction was held for 3 hours and monitored by gas chromatography (GC) until the ethyl octanoate material completely disappeared. After the reaction was completed, cooled to 5~10°C, slowly added concentrated hydrochloric acid (90 mL) to adjust the pH to 6.4~6.7, at which time a large amount of white solid precipitated. The solid was collected by filtration and dried at 50°C for 8 hours. The crude product was recrystallized with benzene to give 78.8 g of white flocculent solid in 91.1% yield.
References
[1] Diana Evstafeva. “Inhibition of urease-mediated ammonia production by 2-octynohydroxamic acid in hepatic encephalopathy.” Nature Communications 15 1 (2024): 2226.
Octanohydroxamic Acid Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Weifang Runzhong Fine Chemical Co., LTD | 18653686003 | sq@runzhongchem.com | China | 81 | 58 |
| Jinan Baozhao Pharmaceutical Technology Co., Ltd. | 0531-82371868 13210529039 | baozhaopharm@163.com | China | 160 | 58 |
| Shandong Suihua Biotechnology Co. Ltd | 15689727968 | freesky2121@163.com | China | 987 | 58 |
| Jiangyin Soteng Biotechnology Co., Ltd. | 0510-86686637 13861630217 | marketingb@suntonchem.com | China | 16 | 58 |
| Shandong Lierbang New Material Co. LTD | 15553337722 13964392203 | 1135818881@qq.com | China | 49 | 58 |
| Wuhan penglei Biotechnology Co., Ltd | 15871464247 17307245989 | 3471278124@qq.com | China | 4990 | 58 |
| Guangzhou Hichvan Chemical Co., Ltd. | 19128722614 | hichvan@163.com | China | 103 | 58 |
| Shandong Suihua Biotechnology Co., Ltd. | 15169101773 15169101773 | 519904247@qq.com | China | 1077 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
Related articles
- Octanohydroxamic Acid: Chemical Properties, Synthesis and Applications
- Octanohydroxamic Acid (Caprylhydroxamic Acid) is an important multifunctional compound with a hydroxamic acid functional group....
- Apr 25,2025
View Latest Price from Octanohydroxamic Acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-17 | CAPRYLOHYDROXAMIC ACID
7377-03-9
|
0.99 | RongNa Biotechnology Co.,Ltd | ||||
 |
2026-09-17 | Octanohydroxamic acid
7377-03-9
|
1KG | 99% | 500mt | Jinan Finer Chemical Co., Ltd | ||
 |
2026-09-17 | Caprylhydroxamic acid
7377-03-9
|
1KG | 99%min | 1000kg | WUHAN FORTUNA CHEMICAL CO., LTD |
-
- CAPRYLOHYDROXAMIC ACID
7377-03-9
- 0.99
- RongNa Biotechnology Co.,Ltd
-
- Octanohydroxamic acid
7377-03-9
- $0.00
- 99%
- Jinan Finer Chemical Co., Ltd
-
- Caprylhydroxamic acid
7377-03-9
- $0.00
- 99%min
- WUHAN FORTUNA CHEMICAL CO., LTD
