Suberohydroxamic acid
- CAS No.
- 38937-66-5
- Chemical Name:
- Suberohydroxamic acid
- Synonyms
- ODHA;SBHA;Soft oxime;[PTYR705]-STAT3;STAT3 (PTYR705);SUBEROHYDROXAMIC ACID;SUBERIC BISHYDROXAMATE;SuberohydroxaMic acid 95%;SuberoylBis-hydroxamicAci;suberic bishydroxamic acid
- CBNumber:
- CB6673028
- Molecular Formula:
- C8H16N2O4
- Molecular Weight:
- 204.22
- MDL Number:
- MFCD00192455
- MOL File:
- 38937-66-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 153-155 °C(lit.) |
|---|---|
| Density | 1.219±0.06 g/cm3(Predicted) |
| storage temp. | −20°C |
| solubility | H2O: soluble |
| pka | 9.18±0.20(Predicted) |
| form | lyophilized powder |
| color | White to Light Beige |
| Stability | Hygroscopic |
| InChI | 1S/C8H16N2O4/c11-7(9-13)5-3-1-2-4-6-8(12)10-14/h13-14H,1-6H2,(H,9,11)(H,10,12) |
| InChIKey | IDQPVOFTURLJPT-UHFFFAOYSA-N |
| SMILES | ONC(=O)CCCCCCC(=O)NO |
| UNSPSC Code | 51111800 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Safety Statements | 22-24/25 |
|---|---|
| WGK Germany | 3 |
| HS Code | 2928009090 |
| Storage Class | 11 - Combustible Solids |
Suberohydroxamic acid price More Price(54)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 559418 | SBHA | 38937-66-5 | 100mg | $149 | 2026-04-30 | Buy |
| Sigma-Aldrich | 390585 | Suberohydroxamic acid 95% | 38937-66-5 | 1g | $84.6 | 2026-04-30 | Buy |
| Cayman Chemical | 10574 | Suberohydroxamic Acid ≥98% | 38937-66-5 | 100mg | $31 | 2026-04-30 | Buy |
| Cayman Chemical | 10574 | Suberohydroxamic Acid ≥98% | 38937-66-5 | 250mg | $70 | 2026-04-30 | Buy |
| Cayman Chemical | 10574 | Suberohydroxamic Acid ≥98% | 38937-66-5 | 500mg | $129 | 2026-04-30 | Buy |
Suberohydroxamic acid Chemical Properties, Uses, Production
Description
Suberohydroxamic acid (SBHA) is a competitive histone deacetylase (HDAC) inhibitor that has been shown to inhibit HDAC1 (IC50 = 0.25 μM) and HDAC3 (IC50 = 0.30 μM). SBHA causes cell differentiation, cell cycle arrest, or apoptosis. HDAC inhibitors, including SBHA, act synergistically to kill cancer cells when used in combination with cytostatic drugs, allowing lower doses of both inhibitors and drugs to be used.
Uses
Histone deacetylase inhibitor. A cell-permeable inhibitor of HDAC1 and HDAC3. Shown to suppresses the growth of proliferating keratinocytes and squamous cell carcinoma cells.
Uses
Inhibits histone deacetylation.
Definition
ChEBI: N,N'-dihydroxyoctanediamide is a hydroxamic acid.
Biological Activity
Suberoyl bis-hydroxamic acid (SBHA) is a Histone deacetylase (HDAC) inhibitor. SBHA inhibits the activity of HDAC1 and HDAC3 with IC50 values of 250 and 300 nM, respectively. SBHA inhibits proliferation, and induces apoptosis in several cancer cell lines. SBHA has been shown to activate Notch signaling in medullary thyroid carcinoma (MTC) cells.
Biochem/physiol Actions
Suberoyl bis-hydroxamic acid (SBHA) is a Histone deacetylase (HDAC) inhibitor. SBHA inhibits the activity of HDAC1 and HDAC3 with IC50 values of 250 and 300 nM, respectively. SBHA inhibits proliferation, and induces apoptosis in several cancer cell lines. SBHA has been shown to activate Notch signaling in medullary thyroid carcinoma (MTC) cells.
References
1. richon vm, emiliani s, verdin e et al. a class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases. proc natl acad sci u s a. 1998 mar 17; 95(6):3003-7.2. zhang xd, gillespie sk, borrow jm, hersey p. the histone deacetylase inhibitor suberic bishydroxamate regulates the expression of multiple apoptotic mediators and induces mitochondria-dependent apoptosis of melanoma cells. mol cancer ther. 2004 apr; 3(4):425-35.
Suberohydroxamic acid Preparation Products And Raw materials
Raw materials
Preparation Products
Suberohydroxamic acid Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Sinopharm Chemical Reagent Co,Ltd. | 86-21-63210123 | sj_scrc@sinopharm.com | China | 9791 | 79 |
| Accendatech Co., LTD. | 13132578992 | sales@accendatech.com | China | 332 | 58 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29985 | 65 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Hefei Yucheng Pharmaceutical Technology Co., Ltd. | 15385513552 | 2904539281@qq.com | China | 220 | 60 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
View Latest Price from Suberohydroxamic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-25 | N,N'-Dihydroxyoctanediamide
38937-66-5
|
$2.20-8.80 | 1kg | 99% | 50kg | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | |
 |
2026-04-22 | Suberoyl bis-hydroxamic acid
38937-66-5
|
$29.00 | 99.88% | 10g | TargetMol Chemicals Inc. | ||
 |
2024-03-28 | Suberohydroxamic acid
38937-66-5
|
25KG | 95% | PNP Biotech Co. Ltd |
-
- N,N'-Dihydroxyoctanediamide
38937-66-5
- $2.20-8.80
- 99%
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
-
- Suberoyl bis-hydroxamic acid
38937-66-5
- $29.00
- 99.88%
- TargetMol Chemicals Inc.
-
- Suberohydroxamic acid
38937-66-5
- $0.00
- 95%
- PNP Biotech Co. Ltd
