2-Chloro-4-fluoro-5-nitrobenzoic acid
- CAS No.
- 114776-15-7
- Chemical Name:
- 2-Chloro-4-fluoro-5-nitrobenzoic acid
- Synonyms
- 2-chloro-4-fluoro-5-nitrobenzoate;2-Chloro-4-fluoro-5-nitrobenzoic ac;2-Chloro-4-fluoro-5-nitrobenzoic acid;5-Carboxy-4-chloro-2-fluoronitrobenzene;2-Chloro-4-fluoro-5-nitrobenzoicacid98%;Benzoic acid, 2-chloro-4-fluoro-5-nitro-;2-Chloro-4-fluoro-5-nitrobenzoic acid 98%;2-Chloro-4-fluoro-5-nitrobenzoic Acid >2-Chloro-4-fluoro-5-nitrobenzoic acid, 97%,
- CBNumber:
- CB1763913
- Molecular Formula:
- C7H3ClFNO4
- Molecular Weight:
- 219.55
- MDL Number:
- MFCD04115715
- MOL File:
- 114776-15-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 146-150 |
|---|---|
| Boiling point | 364.2±42.0 °C(Predicted) |
| Density | 1.689±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Soluble in methanol. |
| pka | 2.32±0.12(Predicted) |
| form | Powder |
| color | White |
| InChI | InChI=1S/C7H3ClFNO4/c8-4-2-5(9)6(10(13)14)1-3(4)7(11)12/h1-2H,(H,11,12) |
| InChIKey | SYZKAFCPWNFONG-UHFFFAOYSA-N |
| SMILES | C(O)(=O)C1=CC([N+]([O-])=O)=C(F)C=C1Cl |
| CAS DataBase Reference | 114776-15-7 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H335-H315-H319 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 | |||||||||
| Hazard Codes | Xi | |||||||||
| Hazard Note | Irritant/Keep Cold | |||||||||
| HS Code | 2916399090 | |||||||||
| NFPA 704 |
|
2-Chloro-4-fluoro-5-nitrobenzoic acid price More Price(66)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | C2446 | 2-Chloro-4-fluoro-5-nitrobenzoic Acid >98.0%(GC)(T) | 114776-15-7 | 5g | $86 | 2026-04-30 | Buy |
| TCI Chemical | C2446 | 2-Chloro-4-fluoro-5-nitrobenzoic Acid >98.0%(GC)(T) | 114776-15-7 | 25g | $256 | 2026-04-30 | Buy |
| Usbiological | 416750 | 2-Chloro-4-fluoro-5-nitrobenzoic Acid | 114776-15-7 | 250mg | $319 | 2026-06-03 | Buy |
| Usbiological | 416750 | 2-Chloro-4-fluoro-5-nitrobenzoic Acid | 114776-15-7 | 1g | $410 | 2026-06-03 | Buy |
| TRC | TRC-C367080-250MG | 2-Chloro-4-fluoro-5-nitrobenzoic Acid | 114776-15-7 | 250mg | $65 | 2026-06-03 | Buy |
2-Chloro-4-fluoro-5-nitrobenzoic acid Chemical Properties, Uses, Production
Uses
2-Chloro-4-fluoro-5-nitrobenzoic acid is used as pharmaceutical intermediate.
Synthesis
2252-51-9
114776-15-7
The general procedure for the synthesis of 2-chloro-4-fluoro-5-nitrobenzoic acid from 2-chloro-4-fluorobenzoic acid was as follows: 50 g of concentrated sulfuric acid and 0.8 g of the catalyst prepared in Example 1 were added to a reaction flask, followed by the addition of 10 g of 2-chloro-4-fluorobenzoic acid in batches. The reaction mixture was stirred at 25°C for 1 hour. The reaction mixture was cooled to 0°C in an ice bath, and then 5 g of fuming nitric acid was added slowly and dropwise, controlling the reaction temperature between -5 and 8°C. The reaction was continued for 5 to 8 hours until the content of 2-chloro-4-fluorobenzoic acid was less than 0.5%. The reaction mixture was slowly poured into 80 g of crushed ice and the solid product was collected by filtration. The filter cake was washed with 30 g of ice water and subsequently air-dried at 65 °C to give 12.0 g of the white solid product 2-chloro-4-fluoro-5-nitrobenzoic acid in 97.1% yield and 97.2% purity. The isomer of formula (II) was 1.1% by weight.
References
[1] Patent: CN106866684, 2017, A. Location in patent: Paragraph 0131-0132; 0204-0205
[2] Patent: CN106905161, 2017, A. Location in patent: Paragraph 0014; 0015; 0016; 0017
[3] Farmaco, 2004, vol. 59, # 6, p. 463 - 471
[4] Synthesis, 1987, # 10, p. 883 - 887
[5] Patent: US2002/45550, 2002, A1
2-Chloro-4-fluoro-5-nitrobenzoic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Qi-Chem Co., Ltd. | 0411-88165951 13601035838 | marketing@qi-chem.com | China | 167 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Ark Pharm, Inc. | 847-367-3680 | sales@arkpharminc.com | United States | 1669 | 56 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
View Latest Price from 2-Chloro-4-fluoro-5-nitrobenzoic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | 2-CHLORO-4-FLUORO-5-NITROBENZOIC ACID
114776-15-7
|
$5.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-02-02 | 2-Chloro-4-fluoro-5-nitrobenzoic Acid
114776-15-7
|
10mg | 99% | 2000tons | Shaanxi Dideu Medichem Co. Ltd | ||
 |
2025-08-27 | 2-Chloro-4-fluoro-5-nitrobenzoic acid
114776-15-7
|
1kg | 98.0%min | 10tons | Wuhan KEMI-WORKS Chemical Co., Ltd. |
-
- 2-CHLORO-4-FLUORO-5-NITROBENZOIC ACID
114776-15-7
- $5.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 2-Chloro-4-fluoro-5-nitrobenzoic Acid
114776-15-7
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- 2-Chloro-4-fluoro-5-nitrobenzoic acid
114776-15-7
- $0.00
- 98.0%min
- Wuhan KEMI-WORKS Chemical Co., Ltd.
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