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3-Fluoro-4-nitroanisole

3-Fluoro-4-nitroanisole structure

CAS No.: 446-38-8

Chemical Name:: 3-Fluoro-4-nitroanisole

Synonyms: 2-Fluoro-4-methoxy-1-nitrobenzene;3-FLUORO-4-NITROANISOLE;Anisole, 3-fluoro-4-nitro-;3-Fluoro-4-nitroanisole 98%;2-Fluoro-4-methoxynitrobenzene;3-Fluor-4-nitrophenylmethylether;Benzene, 2-fluoro-4-methoxy-1-nitro-;2-FLUORO-4-(METHOXY-D3)-1-NITROBENZENE;5-Fluoro3-Fluoro-4-nitroanisole-2-nitrotoluene;2-Fluoro-4-methoxynitrobenzene[3-Fluoro-4-nitroanisole

CBNumber:: CB0678203

Molecular Formula:: C7H6FNO3

Molecular Weight:: 171.13

MDL Number:: MFCD04115632

MOL File:: 446-38-8.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-27 22:52:53

Product description	Number	Pack Size	Price
2-Fluoro-4-methoxy-1-nitrobenzene min. 98.0 %	F1291	5G	$24
2-Fluoro-4-methoxy-1-nitrobenzene min. 98.0 %	F1291	25G	$94
3-Fluoro-4-nitroanisole	FF34197	0.025kg	$150
3-Fluoro-4-nitroanisole 98%	PC2959	5g	$21
3-Fluoro-4-nitroanisole 98%	PC2959	25g	$49
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3-Fluoro-4-nitroanisole Properties

Melting point	57.3
Boiling point	264.5±20.0 °C(Predicted)
Density	1.321±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,2-8°C
form	crystalline solid
color	Off-white
InChI	InChI=1S/C7H6FNO3/c1-12-5-2-3-7(9(10)11)6(8)4-5/h2-4H,1H3
InChIKey	PLEJCMKVJYUUBA-UHFFFAOYSA-N
SMILES	C1([N+]([O-])=O)=CC=C(OC)C=C1F
UNSPSC Code	12352200

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H317-H319
Precautionary statements	P280-P305+P351+P338
target organs	Respiratory system
Hazard Codes	Xi,C
Risk Statements	34
Safety Statements	26-36/37/39-45
RIDADR	3261
WGK Germany	WGK 3
Hazard Note	Irritant/Keep Cold
HazardClass	8
PackingGroup	Ⅱ
HS Code	2909309090
Storage Class	8A - Combustible corrosive hazardous materials
Hazard Classifications	Aquatic Chronic 3 Eye Dam. 1 Skin Corr. 1B STOT SE 3

3-Fluoro-4-nitroanisole price More Price(52)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	F1291	2-Fluoro-4-methoxy-1-nitrobenzene min. 98.0 %	446-38-8	5G	$24	2026-04-30	Buy
TCI Chemical	F1291	2-Fluoro-4-methoxy-1-nitrobenzene min. 98.0 %	446-38-8	25G	$94	2026-04-30	Buy
Biosynth	FF34197	3-Fluoro-4-nitroanisole	446-38-8	0.025kg	$150	2026-06-04	Buy
Apolloscientific	PC2959	3-Fluoro-4-nitroanisole 98%	446-38-8	5g	$21	2026-06-04	Buy
Apolloscientific	PC2959	3-Fluoro-4-nitroanisole 98%	446-38-8	25g	$49	2026-06-04	Buy

Product number	Packaging	Price	Buy
F1291	5G	$24	Buy
F1291	25G	$94	Buy
FF34197	0.025kg	$150	Buy
PC2959	5g	$21	Buy
PC2959	25g	$49	Buy

3-Fluoro-4-nitroanisole Chemical Properties,Uses,Production

Uses

3-Fluoro-4-nitroanisole is synthesizing new antiseptic-germicide, sterilant, and the important organic fluoride-containing intermediate of liquid crystal material.

Synthesis

394-41-2

74-88-4

446-38-8

3-Fluoro-4-nitrophenol (75 g, 0.48 mol) was dissolved in acetone (700 mL) and cooled in an ice water bath. Subsequently, 1,8-diazabicyclo[5,4,0]undec-7-ene (145 g, 0.96 mol) was added slowly over about 1 hour and the reaction was held for 5 minutes. Next, iodomethane (135 g, 0.96 mol) was added dropwise over 10 min. The reaction mixture was stirred at room temperature for 16 hours. After that, 1,8-diazabicyclo[5,4,0]undec-7-ene (73 g, 0.48 mol) and iodomethane (68 g, 0.48 mol) were added and the mixture was heated to 50 °C and maintained for 1 hour. After completion of the reaction, the solid insoluble material was removed by filtration and the filtrate was concentrated and mixed with ethyl acetate and 1 M hydrochloric acid. The organic layer was washed sequentially with hydrochloric acid and aqueous sodium bicarbonate, concentrated and precipitated as a solid by stirring in a hexane solution of 1% ethyl acetate. Finally, the product 3-fluoro-4-nitroanisole (72 g, 88% yield) was collected and air dried.

References

[1] Chemistry - A European Journal, 2009, vol. 15, # 4, p. 885 - 900
[2] Chemistry - A European Journal, 2014, vol. 20, # 39, p. 12553 - 12558
[3] Patent: WO2004/76455, 2004, A1. Location in patent: Page 24
[4] Patent: US2007/232603, 2007, A1. Location in patent: Page/Page column 16
[5] Chemistry - A European Journal, 2013, vol. 19, # 29, p. 9599 - 9605

3-Fluoro-4-nitroanisole Preparation Products And Raw materials

Raw materials

5-Fluoro-2-nitroanisole 2,4-Dimethoxy-1-nitrobenzene 2,4-Difluoronitrobenzene 3-Fluoro-4-nitrophenol Dimethyl sulfate

Potassium methoxide Iodomethane (TRIMETHYLSILYL)DIAZOMETHANE DBU Sodium Methoxide

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Preparation Products

2-fluoro-4-methoxy-5-nitrophenylamine Carbamic acid, N-[2-[(5-methoxy-2-nitrophenyl)amino]ethyl]-, 1,1-dimethylethyl ester

3-Fluoro-4-nitroanisole Suppliers

Global( 220)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shaanxi Dideu Medichem Co. Ltd	+86-29-81139210 17389186172	1077@dideu.com	China	3999	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20111	58
Hefei Lbao Physical & Chemical Science Co.,Ltd	+1-5184799099;	lbaochemicals@gmail.com	China	670	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29626	60
Fluoropharm Co., Ltd.	+86-0571-85586753 +86-13336034509	sales@fluoropharm.com	China	1444	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32998	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29766	58
Zhejiang ZETian Fine Chemicals Co. LTD	18957127338	stella@zetchem.com	China	2993	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10399	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63645	58

Supplier	Advantage
Shaanxi Dideu Medichem Co. Ltd	58
Henan Fengda Chemical Co., Ltd	58
Hefei Lbao Physical & Chemical Science Co.,Ltd	58
Capot Chemical Co.,Ltd.	60
Fluoropharm Co., Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Zhejiang ZETian Fine Chemicals Co. LTD	58
Shenzhen Nexconn Pharmatechs Ltd	58
Alchem Pharmtech,Inc.	58

View Lastest Price from 3-Fluoro-4-nitroanisole manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-08-11	5-Fluoro3-Fluoro-4-nitroanisole-2-nitrotoluene 446-38-8	$1.00-200.00	1KG	99%, 99.5% Sublimated		Henan Fengda Chemical Co., Ltd
2026-08-07	3-Fluoro-4-nitroanisole 446-38-8	$1.00-28.00	1KG	99%	20000KG	Shaanxi Dideu Medichem Co. Ltd
2026-06-30	3-Fluoro-4-nitroanisole 446-38-8		1kg	99%	10000KGS	Shaanxi Dideu New Materials Co. Ltd

5-Fluoro3-Fluoro-4-nitroanisole-2-nitrotoluene
446-38-8
$1.00-200.00
99%, 99.5% Sublimated
Henan Fengda Chemical Co., Ltd

3-Fluoro-4-nitroanisole
446-38-8
$1.00-28.00
99%
Shaanxi Dideu Medichem Co. Ltd

3-Fluoro-4-nitroanisole
446-38-8
$0.00
99%
Shaanxi Dideu New Materials Co. Ltd

3-Fluoro-4-nitroanisole Spectrum

3-Fluoro-4-nitroanisole(446-38-8)¹HNMR 3-Fluoro-4-nitroanisole(446-38-8)FT-IR

446-38-8(3-Fluoro-4-nitroanisole)Related Search:

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2,3-Difluoro-4-nitroanisole 4-BENZYLOXY-2-FLUORO-1-NITROBENZENE 4-ETHOXY-2-FLUORO-1-NITROBENZENE 2-CHLORO-4-FLUORO-5-NITROANISOLE 4-Fluoro-2-nitroanisole98%,4-Fluoro-2-nitroanisole 98%,4-FLUORO-2-NITROANISOLE

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3-FLUORO-4-NITROANISOLE 2-Fluoro-4-methoxynitrobenzene 2-Fluoro-4-methoxynitrobenzene, 3-Fluoro-4-nitrophenyl methyl ether 3-Fluoro-4-nitroanisole 98% Anisole, 3-fluoro-4-nitro- Benzene, 2-fluoro-4-methoxy-1-nitro- 3-Fluor-4-nitrophenylmethylether 2-FLUORO-4-(METHOXY-D3)-1-NITROBENZENE 2-Fluoro-4-methoxynitrobenzene[3-Fluoro-4-nitroanisole 5-Fluoro3-Fluoro-4-nitroanisole-2-nitrotoluene 2-Fluoro-4-methoxy-1-nitrobenzene 446-38-8 blocks FluoroCompounds NitroCompounds Aromatic Halides (substituted) K00001