3-Hydroxy-2-methylbenzoic acid
- CAS No.
- 603-80-5
- Chemical Name:
- 3-Hydroxy-2-methylbenzoic acid
- Synonyms
- HMBA;3-HYDROXY-O-TOLUIC ACID;NSC 73133;3,2-Cresotic Acid;Hydroxytoluicacid,98%;3-HYDROXY-2-TOLUIC ACID;2-Methyl-3-Hydroxybenzoic;3-Hydroxy-2-methylbenzoicaci;2-Methyl-3-hydroxybenzoicacid;3-HYDROXY-2-METHYLBENZOIC ACID
- CBNumber:
- CB9179596
- Molecular Formula:
- C8H8O3
- Molecular Weight:
- 152.15
- MDL Number:
- MFCD00671541
- MOL File:
- 603-80-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 143-148°C |
|---|---|
| Boiling point | 336.6±30.0 °C(Predicted) |
| Density | 1.304±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 3.83±0.10(Predicted) |
| color | Light Yellow |
| BRN | 2613791 |
| InChI | InChI=1S/C8H8O3/c1-5-6(8(10)11)3-2-4-7(5)9/h2-4,9H,1H3,(H,10,11) |
| InChIKey | RIERSGULWXEJKL-UHFFFAOYSA-N |
| SMILES | C(O)(=O)C1=CC=CC(O)=C1C |
| CAS DataBase Reference | 603-80-5(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P280g-P305+P351+P338 | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29182900 | |||||||||
| NFPA 704 |
|
3-Hydroxy-2-methylbenzoic acid price More Price(61)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PH005167 | 3-hydroxy-2-methylbenzoic acid AldrichCPR | 603-80-5 | 5mg | $172 | 2023-06-20 | Buy |
| TCI Chemical | H0885 | 3-Hydroxy-2-methylbenzoic Acid >98.0%(T) | 603-80-5 | 1g | $22 | 2026-04-30 | Buy |
| TCI Chemical | H0885 | 3-Hydroxy-2-methylbenzoic Acid >98.0%(T) | 603-80-5 | 5g | $33 | 2026-04-30 | Buy |
| Usbiological | 278679 | 3-Hydroxy-2-methylbenzoic acid Asreported | 603-80-5 | 5g | $305 | 2026-06-03 | Buy |
| Usbiological | 278679 | 3-Hydroxy-2-methylbenzoic acid Asreported | 603-80-5 | 10g | $403 | 2026-06-03 | Buy |
3-Hydroxy-2-methylbenzoic acid Chemical Properties,Uses,Production
Chemical Properties
Light Yellow Crystalline Solid
Uses
3-Hydroxy-2-methylbenzoic Acid (cas# 603-80-5) is a compound useful in organic synthesis.
Synthesis
52130-17-3
603-80-5
General procedure for the synthesis of 2-methyl-3-hydroxybenzoic acid from 3-amino-2-methylbenzoic acid: to 5 mL of water containing 0.65 mL of concentrated sulfuric acid, a cold (0°C) suspension of 0.54 g (3.3 mmol) of 2-methyl-3-aminobenzoic acid was added, followed by 0.25 g (3.6 mmol) of solid sodium nitrite. After about 15 minutes of reaction, the mixture was poured into 20 mL of warm water containing 4 mL of concentrated sulfuric acid. The reaction mixture was slowly heated to 90°C and gas was observed to escape. When gas release ceased, the solution was cooled to room temperature and extracted with ethyl acetate. The organic layers were combined, washed with 0.5 N hydrochloric acid, dried and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (eluent: 5% dichloromethane solution in methanol) to give 350 mg of white solid (melting point: 137-138°C) in 69% yield.1H NMR (CDCl3) data: δ 8.18 (br.s, 1H), 7.42 (d, J = 7.7 Hz, 1H), 7.13 (t, J = 7.9 Hz, 1H) , 6.93 (d, J = 7.9 Hz, 1H), 2.46 (s, 3H). Elemental analysis (C8H8O3) results: calculated values: C, 63.15; H, 5.29; measured values: C, 63.32; H, 5.36.
References
[1] Patent: US6335/459, 2002, B1. Location in patent: Page column 29
[2] Patent: US6335459, 2002, B1. Location in patent: Page column 29
[3] Tetrahedron Letters, 2000, vol. 41, # 11, p. 1741 - 1745
[4] Patent: US5952343, 1999, A
[5] Patent: US5484926, 1996, A
3-Hydroxy-2-methylbenzoic acid Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Harvest Chemical Industrial Co., Ltd. | 15721252604 17321035817 | sales@harvest-chem.com | China | 2829 | 64 |
| Changzhou Jintan Kuncheng Biotechnology Co., Ltd | 13814785958 | 772059499@qq.com | China | 73 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | 021-50182298 021-50180596 | sales@boylechem.com | China | 2202 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| future industrial shanghai co., ltd | 400-0066400 13621662912 | sales@jonln.com | China | 1989 | 65 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TAIYUAN RHF CO.,LTD. | +86 351 7031519 | sales@RHFChem.com | China | 2334 | 56 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
View Lastest Price from 3-Hydroxy-2-methylbenzoic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-06-30 | 3-Hydroxy-2-methylbenzoic acid
603-80-5
|
1KG | 98.0% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2025-06-20 | 3-Hydroxy-2-methylbenzoic acid
603-80-5
|
1kg | 98.00% | 20tons | Hebei Yanxi Chemical Co., Ltd. | ||
 |
2025-04-04 | 3-Hydroxy-2-methylbenzoic acid
603-80-5
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. |
-
- 3-Hydroxy-2-methylbenzoic acid
603-80-5
- 98.0%
- Shaanxi Dideu New Materials Co. Ltd
-
- 3-Hydroxy-2-methylbenzoic acid
603-80-5
- $0.00
- 98.00%
- Hebei Yanxi Chemical Co., Ltd.
-
- 3-Hydroxy-2-methylbenzoic acid
603-80-5
- 98%
- Henan Aochuang Chemical Co.,Ltd.
