PROGLUMETACIN MALEATE
- CAS No.
- 57132-53-3
- Chemical Name:
- PROGLUMETACIN MALEATE
- Synonyms
- PROGLUMETACIN;Proglumetacine;PROGLUMETACIN MALEATE;1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid 2-[4-[3-[[4-(benzoylamino)-5-(dipropylamino)-1,5-dioxopentyl]oxy]propyl]-1-piperazinyl]ethyl ester;1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, 2-[4-[3-[[4-(benzoylamino)-5-(dipropylamino)-1,5-dioxopentyl]oxy]propyl]-1-piperazinyl]ethyl ester (9CI);1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, 2-[4-[3-[[4-(benzoylamino)-5-(dipropylamino)-1,5-dioxopentyl]oxy]propyl]-1-piperazinyl]ethyl ester, (+-)-
- CBNumber:
- CB9188310
- Molecular Formula:
- C46H58ClN5O8
- Molecular Weight:
- 844.43
- MDL Number:
- MFCD00866080
- MOL File:
- 57132-53-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| solubility | DMSO (Slightly), Methanol (Slightly, Heated, Sonicated) |
|---|---|
| form | Solid |
| color | White to Pale Yellow |
| FDA UNII | FV919079LU |
| ATC code | M01AB14 |
PROGLUMETACIN MALEATE price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 287563 | Proglumetacin Asreported | 57132-53-3 | 5mg | $433 | 2026-06-03 | Buy |
| Usbiological | 287563 | Proglumetacin Asreported | 57132-53-3 | 10mg | $615 | 2026-06-03 | Buy |
| Usbiological | 287563 | Proglumetacin Asreported | 57132-53-3 | 25mg | $864 | 2026-06-03 | Buy |
| Usbiological | 287563 | Proglumetacin Asreported | 57132-53-3 | 50mg | $1218 | 2026-06-03 | Buy |
| Usbiological | 287563 | Proglumetacin Asreported | 57132-53-3 | 100mg | $1746 | 2026-06-03 | Buy |
PROGLUMETACIN MALEATE Chemical Properties, Uses, Production
Uses
Proglumetacin Dioxalate is a new non-steroidal anti-inflammatory drug.
Definition
ChEBI: A carboxylic ester obtained by formal condensation of the carboxy group of indometacin with the hydroxy group of 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl N2-benzoyl-N,N-dipropy -alpha-glutaminate. Used (as its dimaleate salt) to control pain and inflammation associated with musculoskeletal and joint disorders. Following oral administration, it is metabolised to indometacin and proglumide, a drug with antisecretor effects that helps prevent injury to the stomach lining.
Synthesis
The reaction of N-benzoyl-N_x0002_,
N_x0002_-di-n-propyl-dl-isoglutamin (proglumide) with 1-(3-chloropropyl)-4-(2-hydroxyethyl)-piperazine
obtained from 1-(2-hydroxyethyl)piperazine
and 1-bromo-3-chloropropane by
means of sodium methanolate in DMSO at
105C gives N--N_x0002_-(2-hydroxyethyl)
piperazine, which is then condensated
with Indomethacin (1-(p-chlorobenzoyl)-
5-methoxy-2-methylindole-3-acetic acid)
by means of dicyclohexylcabodiimide and
NaHCO3 in ethyl acetate .
in vivo
Proglumetacin (Sprague-Dawley rats, 0-30 mg/kg, Orally, once) dose-dependently inhibits accumulation of pouch exudate[1].
| Animal Model: | Sprague-Dawley rats (6 weeks) |
| Dosage: | 0, 0.3, 3, 9, 30 mg/kg |
| Administration: | Orally, once |
| Result: | Caused dose-dependent reduction of leukocyte migration into the pouch exudate, caused 49.2% inhibition at 30 mg/kg; and markedly decreased the prostaglandin E2 content of the pouch exudate, but tended to increase the leukotriene B 4 content. |
PROGLUMETACIN MALEATE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Shenzhen SUNGENING Bio-Medical Co., Ltd. | 0755-28967200 13631290199 | wxf@sungening.com | China | 9609 | 60 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29626 | 60 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 | sales@rrkchem.com | China | 57336 | 58 |
| DAYANG CHEM (HANGZHOU) CO.,LTD | +86-88938639 +86-17705817739 | info@dycnchem.com | China | 53589 | 58 |
