N-Methyl-beta-carboline-3-carboxamide
- CAS No.
- 78538-74-6
- Chemical Name:
- N-Methyl-beta-carboline-3-carboxamide
- Synonyms
- LSU-65;FG 7142;Zk-31906;ZK 39106;β-CCA methylamide;FG 7142, 10 mM in DMSO;N-Methyl-β-carboline-3-carboxamide;N-Methyl-beta-carboline-3-carboxamide;B-carboline-3-carboxylic acid N-*methylamide;4-b)indole-3-carboxamide,n-methyl-9h-pyrido(
- CBNumber:
- CB9228957
- Molecular Formula:
- C13H11N3O
- Molecular Weight:
- 225.25
- MDL Number:
- MFCD00055075
- MOL File:
- 78538-74-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 269-270° |
|---|---|
| Boiling point | 576.3±30.0 °C(Predicted) |
| Density | 1.328±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | ethanol: 1 mg/mL |
| pka | 13.44±0.46(Predicted) |
| form | A crystalline solid |
| color | light tan |
| InChI | 1S/C13H11N3O/c1-14-13(17)11-6-9-8-4-2-3-5-10(8)16-12(9)7-15-11/h2-7,16H,1H3,(H,14,17) |
| InChIKey | QMCOPDWHWYSJSA-UHFFFAOYSA-N |
| SMILES | CNC(=O)c1cc2c(cn1)[nH]c3ccccc23 |
| EWG's Food Scores | 1 |
| FDA UNII | 60PO70N1BP |
| UNSPSC Code | 12352106 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P302+P352-P304+P340-P305+P351+P338 |
| PPE | Eyeshields, Gloves, type N95 (US) |
| WGK Germany | 3 |
| RTECS | UU9780100 |
| Storage Class | 11 - Combustible Solids |
N-Methyl-beta-carboline-3-carboxamide price More Price(63)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | E006 | β-Carboline-3-carboxylic acid N-methylamide | 78538-74-6 | 100mg | $311 | 2026-04-30 | Buy |
| Sigma-Aldrich | E006 | β-Carboline-3-carboxylic acid N-methylamide | 78538-74-6 | 500mg | $1070 | 2026-04-30 | Buy |
| Cayman Chemical | 29183 | FG-7142 ≥98% | 78538-74-6 | 50mg | $103 | 2026-04-30 | Buy |
| Cayman Chemical | 29183 | FG-7142 ≥98% | 78538-74-6 | 100mg | $169 | 2026-04-30 | Buy |
| Cayman Chemical | 29183 | FG-7142 | 78538-74-6 | 10mg | $59 | 2021-12-16 | Buy |
N-Methyl-beta-carboline-3-carboxamide Chemical Properties, Uses, Production
Description
FG 7142 (ZK 39106; LSU-65) is a nonselective benzodiazepine inverse agonist with high affinity (Ki= 91 nM) for the α1 subunit-containing GABAA receptor. FG 7142 also modulates GABA-induced chloride flux (EC50=137 nM) at GABAA receptors expressing the α1 subunit. FG 7142 increases tyrosine hydroxylation and leads to upregulation of β-adrenergic receptors in mouse cerebral cortex.
Uses
FG 7142 is a benzodiazepine inverse agonist anxiogenic compound.
Definition
ChEBI: N-methyl-9H-pyrido[3,4-b]indole-3-carboxamide is a member of beta-carbolines.
Biological Activity
Inverse agonist and anxiogenic agent. Increases tyrosine hydroxylation and causes upregulation of β -adrenoceptors in mouse cerebral cortex.
Biochem/physiol Actions
Benzodiazepine inverse receptor agonist; potent anxiogenic agent.
storage
Store at RT
N-Methyl-beta-carboline-3-carboxamide Preparation Products And Raw materials
Raw materials
Preparation Products
N-Methyl-beta-carboline-3-carboxamide Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| Shanghai Beckham Medical Technology Co., Ltd | 13816613772 | huahero21@sina.com | China | 2994 | 55 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8435 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
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