3-Amino-4-fluorobenzoic acid
- CAS No.
- 2365-85-7
- Chemical Name:
- 3-Amino-4-fluorobenzoic acid
- Synonyms
- 3-Amino-4-fL;Afatinib Impurity Y;Afatinib Impurity 93;3-Amino-4-Fluorobenzoic;5-Carboxy-2-fluoroaniline;3-AMINO-4-FLUOROBENZOIC ACID;Benzoicacid, 3-amino-4-fluoro-;3-azanyl-4-fluoro-benzoic acid;3-Amino-4-fluorobenzoic Acid >3-AMino-4-fluorobenzoic Acid, 97+%
- CBNumber:
- CB9239614
- Molecular Formula:
- C7H6FNO2
- Molecular Weight:
- 155.13
- MDL Number:
- MFCD00130055
- MOL File:
- 2365-85-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 3-Amino-4-fluorobenzoic Acid >97.0%(T) | A1972 | 5g | $93 |
| 3-Amino-4-fluorobenzoic Acid | A634640 | 100mg | $75 |
| 3-Amino-4-fluorobenzoic acid | 4657-3-06 | 25g | $82 |
| 3-Amino-4-fluorobenzoic Acid | PC9442 | 25g | $74 |
| 3-Amino-4-fluorobenzoic acid | FA64177 | 25g | $100 |
| More product size | |||
| Melting point | 184 °C |
|---|---|
| Boiling point | 335.5±27.0 °C(Predicted) |
| Density | 1.430±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | soluble in Methanol |
| pka | 4.30±0.10(Predicted) |
| form | Powder |
| color | Off-white |
| InChI | InChI=1S/C7H6FNO2/c8-5-2-1-4(7(10)11)3-6(5)9/h1-3H,9H2,(H,10,11) |
| InChIKey | WFSPEVFSRUTRCN-UHFFFAOYSA-N |
| SMILES | C(O)(=O)C1=CC=C(F)C(N)=C1 |
| CAS DataBase Reference | 2365-85-7(CAS DataBase Reference) |
| FDA UNII | REU8GMY5DP |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 22 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2922498590 | |||||||||
| NFPA 704 |
|
3-Amino-4-fluorobenzoic acid price More Price(32)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | A1972 | 3-Amino-4-fluorobenzoic Acid >97.0%(T) | 2365-85-7 | 5g | $93 | 2024-03-01 | Buy |
| TRC | A634640 | 3-Amino-4-fluorobenzoic Acid | 2365-85-7 | 100mg | $75 | 2021-12-16 | Buy |
| SynQuest Laboratories | 4657-3-06 | 3-Amino-4-fluorobenzoic acid | 2365-85-7 | 25g | $82 | 2021-12-16 | Buy |
| Apolloscientific | PC9442 | 3-Amino-4-fluorobenzoic Acid | 2365-85-7 | 25g | $74 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FA64177 | 3-Amino-4-fluorobenzoic acid | 2365-85-7 | 25g | $100 | 2021-12-16 | Buy |
3-Amino-4-fluorobenzoic acid Chemical Properties,Uses,Production
Chemical Properties
off-white powder
Synthesis
453-71-4
2365-85-7
3-Nitro-4-fluorobenzoic acid (1.85 g, 10.0 mmol) was dissolved in methanol (10 mL) and 5% Pd/C catalyst (100 mg) was added. The reaction mixture was stirred for 6 hours under hydrogen atmosphere. Upon completion of the reaction, the catalyst was removed by filtration and the filter cake was washed with methanol. The filtrate was concentrated under reduced pressure to remove the volatile solvent to afford the target product 3-amino-4-fluorobenzoic acid (8A) as a light yellow solid (1.50 g, 9.67 mmol, 97% yield).
References
[1] Patent: US2004/77696, 2004, A1. Location in patent: Page/Page column 11
[2] Patent: WO2010/126922, 2010, A1. Location in patent: Page/Page column 60
[3] Tetrahedron, 2018, vol. 74, # 47, p. 6795 - 6803
[4] Journal of Organic Chemistry, 2014, vol. 79, # 11, p. 5134 - 5144
[5] Beilstein Journal of Organic Chemistry, 2013, vol. 9, p. 1873 - 1880
3-Amino-4-fluorobenzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29640 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29819 | 58 |
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4241 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10404 | 58 |
| Jinan Finer Chemical Co., Ltd | +86-531-88989536 +86-15508631887 | sales@finerchem.com | China | 2949 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14332 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569262 +86-15003564040 | 1056@dideu.com | China | 3982 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10000 | 58 |
View Lastest Price from 3-Amino-4-fluorobenzoic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-03-12 | Afatinib Impurity 93 | US $0.00-0.00 / mg | 10mg | 98% | 500mg | ShenZhen H&D Pharmaceutical Technology Co., LTD | |
 |
2026-02-02 | 3-Amino-4-fluorobenzoic acid
2365-85-7
|
US $0.00-0.00 / KG | 1g | 99% | 2000tons | Shaanxi Dideu Medichem Co. Ltd | |
 |
2019-09-02 | 3-Amino-4-fluorobenzoic acid
2365-85-7
|
US $1.00 / KG | 1KG | 98% | 1kg; 10kg; 100kg | Career Henan Chemical Co |
-
- Afatinib Impurity 93
- US $0.00-0.00 / mg
- 98%
- ShenZhen H&D Pharmaceutical Technology Co., LTD
-
- 3-Amino-4-fluorobenzoic acid
2365-85-7
- US $0.00-0.00 / KG
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- 3-Amino-4-fluorobenzoic acid
2365-85-7
- US $1.00 / KG
- 98%
- Career Henan Chemical Co
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