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ChemicalBook >> CAS DataBase List >>3-Amino-1H-pyrazole-4-carboxamide

3-Amino-1H-pyrazole-4-carboxamide

3-Amino-1H-pyrazole-4-carboxamide Structure
3-Amino-1H-pyrazole-4-carboxamide structure
CAS No.
5334-31-6
Chemical Name:
3-Amino-1H-pyrazole-4-carboxamide
Synonyms
3-AMINOPYRAZOLE-4-CARBOXAMIDE;Allopurinol EP IMpurity A;3-Amino-4-carbamoylpyrazole;3-AMino-1H-pyrazole-4-car...;5-Amino-1H-pyrazole-4-car...;5-Amino-4-pyrazolecarboxamide;3-Amino-1H-pyrazole-4-formamide;3-Amino-1H-pyrazole-4-carboxamide;5-azanyl-1H-pyrazole-4-carboxamide;1H-Pyrazole-4-carboxamide, 3-amino-
CBNumber:
CB9244036
Molecular Formula:
C4H6N4O
Molecular Weight:
126.12
MDL Number:
MFCD00082808
MOL File:
5334-31-6.mol
MSDS File:
SDS
Last updated:2026-05-28 04:54:42
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3-Amino-1H-pyrazole-4-carboxamide Properties

Melting point 187-189 °C(Solv: water (7732-18-5))
Boiling point 454.3±25.0 °C(Predicted)
Density 1.538±0.06 g/cm3(Predicted)
storage temp. 2-8°C(protect from light)
solubility DMSO (Slightly), Methanol (Very Slightly)
form Solid
pka 13.26±0.50(Predicted)
color Off-White to Pale Beige
FDA UNII G43E3B7590

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
HS Code  2933199090

3-Amino-1H-pyrazole-4-carboxamide price More Price(53)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Usbiological 434949 5-Amino-4-pyrazolecarboxamide 5334-31-6 1g $319 2026-06-03 Buy
Usbiological 434949 5-Amino-4-pyrazolecarboxamide 5334-31-6 5g $489 2026-06-03 Buy
TRC TRC-A628745-5G 5-Amino-4-pyrazolecarboxamide 5334-31-6 5g $165 2026-06-03 Buy
TRC TRC-A628745-1G 5-Amino-4-pyrazolecarboxamide 5334-31-6 1g $74 2026-06-03 Buy
AstaTech 52177 3-AMINO-PYRAZOLE-4-CARBOXYLIC ACID AMIDE 97% 5334-31-6 25G $67 2026-04-30 Buy
Product number Packaging Price Buy
434949 1g $319 Buy
434949 5g $489 Buy
TRC-A628745-5G 5g $165 Buy
TRC-A628745-1G 1g $74 Buy
52177 25G $67 Buy

3-Amino-1H-pyrazole-4-carboxamide Chemical Properties, Uses, Production

Uses

5-Amino-4-pyrazolecarboxamide is used in the synthesis of 4H-3,1-Benzothiazinone analogs as antiproliferative agents against human cancer cell lines. Also, it is an intermediate used in the synthesis of 3-(4H-1,2,4-Triazol-4-yl)-1H-pyrazole-4-carboxamide (T767570), which is an impurity of Allopurinol (A547300), which is a xanthine oxidase inhibitor; decreases uric acid production. Used in treatment of hyperuricemia and chronic gout. Antiurolithic.

Synthesis

3-Amino-4-pyrazolecarbonitrile

16617-46-2

3-Amino-1H-pyrazole-4-carboxamide

5334-31-6

General procedure for the synthesis of 3-aminopyrazole-4-carboxamide from 3-amino-4-cyanopyrazole: 5-amino-1H-pyrazole-4-carbonitrile (1) (5 g, 0.046 mol) was slowly added to pre-cooled concentrated sulfuric acid (10 ml) under stirring conditions, and the temperature of the reaction was controlled not to exceed 20 °C. After the addition was completed, the reaction mixture was stirred continuously at room temperature for 4 hours. Subsequently, the reaction solution was slowly poured into ice water under stirring and the mixture was allowed to stand in a refrigerator overnight. The precipitated solid product was collected by filtration and washed with water to remove residual sulfuric acid, which ultimately yielded the target compound 5-amino-1H-pyrazole-4-carboxamide (2) as a white solid with a yield of 5.19 g in 89% yield; melting point 220-222 °C (literature value 222-225 °C) [33].

References

[1] Bioorganic Chemistry, 2018, vol. 79, p. 46 - 59
[2] European Journal of Medicinal Chemistry, 2017, vol. 126, p. 24 - 35
[3] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 5, p. 1191 - 1196

3-Amino-1H-pyrazole-4-carboxamide Preparation Products And Raw materials

Raw materials

3-Amino-4-pyrazolecarbonitrile

Preparation Products

3-Amino-1H-pyrazole-4-carboxamide Suppliers

Global Suppliers ( 167)
Supplier Tel Email Country ProdList Advantage
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Beijing Ouhe Technology Co., Ltd 13552068683 13522913783 2355560935@qq.com China 11777 60
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418 sales@chemreagents.com United States 10174 62
Accela ChemBio Co.,Ltd. 021-50795510 4000665055 marketing@accelachem.com China 10972 64
Shanghai Longsheng chemical Co.,Ltd. 58099637 13585536065 sales@shlschem.com China 9880 59
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Syntechem Co.,Ltd info@syntechem.com China 12973 57
Shanghai Sphchem Co., Ltd. 021-56491756 13512199871 2819742715@qq.com China 3994 55
Heterochem 027-88041443 13072715837 sales@hetero-chem.com China 695 58
Chengdu HappySyn Pharmaceutical Technology Co., Ltd. 85114309 18982182443 yangli@happysyn.com China 2297 55
Supplier Advantage
Energy Chemical 61
Beijing Ouhe Technology Co., Ltd 60
Pure Chemistry Scientific Inc. 62
Accela ChemBio Co.,Ltd. 64
Shanghai Longsheng chemical Co.,Ltd. 59
Shanghai Hanhong Scientific Co.,Ltd. 64
Syntechem Co.,Ltd 57
Shanghai Sphchem Co., Ltd. 55
Heterochem 58
Chengdu HappySyn Pharmaceutical Technology Co., Ltd. 55

View Latest Price from 3-Amino-1H-pyrazole-4-carboxamide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3-Amino-1H-pyrazole-4-carboxamide pictures 2020-01-03 3-Amino-1H-pyrazole-4-carboxamide
5334-31-6
 $9.80 1g ≥99.0% 100kg Career Henan Chemical Co

3-Amino-1H-pyrazole-4-carboxamide Spectrum

3-Amino-1H-pyrazole-4-carboxamide(5334-31-6)1HNMR

5334-31-6 (3-Amino-1H-pyrazole-4-carboxamide) Related Search:

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1of4

3-AMINOPYRAZOLE-4-CARBOXAMIDE 5-Amino-1H-pyrazole-4-carboxylic amide 3-Amino-1H-pyrazole-4-carboxamide 5-azanyl-1H-pyrazole-4-carboxamide 3-AMINO-PYRAZOLE-4-CARBOXYLIC ACID AMIDE 5-Amino-1H-pyrazole-4-car... 3-AMino-1H-pyrazole-4-car... 3-AMino-1H-pyrazole-4-carboxylic aMide Allopurinol EP IMpurity A 5-aMino-1H-pyrazole-4-carboxaMide hydrochloride 3-Amino-1H-pyrazole-4-carboxamide 98% 3-Amino-4-carbamoyl-1H-pyrazole, 3-Amino-4-(aminocarbonyl)-1H-pyrazole 3-Amino-1H-pyrazole-4-carboxylic acid amide 3-Amino-4-carbamoylpyrazole (E)-3-methyl-2-pentenedioic acid dimethyl ester 5-Amino-4-pyrazolecarboxamide 1H-Pyrazole-4-carboxamide, 3-amino- 3-Amino-1H-pyrazole-4-formamide 3-Amino-4- pyrazole carboxamide hemisulphate 3 – Amino -1 H-Pyrazole-4-Carbaoxamide 3-amino-1H-pyridineazole-4-carboxamide 5334-31-6 CH3CH22CHBrCH2CH3