Oxipurinol
- CAS No.
- 2465-59-0
- Chemical Name:
- Oxipurinol
- Synonyms
- OXYPURINOL;Alloxanthine;Oxyprim;BW-55-5;NSC-76239;Oxipurino;OXIPURINOL;1,7-Dihydro-;Oxoallopurinol;Allopurinol Impurity5
- CBNumber:
- CB4709190
- Molecular Formula:
- C5H4N4O2
- Molecular Weight:
- 152.11
- MDL Number:
- MFCD00047205
- MOL File:
- 2465-59-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 300 °C |
|---|---|
| Boiling point | 274.55°C (rough estimate) |
| Density | 1.637 |
| refractive index | 1.8500 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Soluble in DMSO. |
| pka | pKa 7.7 (Uncertain) |
| form | Powder |
| color | Light yellow |
| BRN | 139956 |
| Stability | Hygroscoipic |
| InChI | InChI=1S/C5H4N4O2/c10-4-2-1-6-9-3(2)7-5(11)8-4/h1H,(H3,6,7,8,9,10,11) |
| InChIKey | HXNFUBHNUDHIGC-UHFFFAOYSA-N |
| SMILES | C1(=O)NC(=O)C2C=NNC=2N1 |
| CAS DataBase Reference | 2465-59-0(CAS DataBase Reference) |
| FDA UNII | G97OZE5068 |
| EPA Substance Registry System | Oxypurinol (2465-59-0) |
| UNSPSC Code | 41106305 |
| NACRES | NA.51 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 36 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29335990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
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| NFPA 704 |
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Oxipurinol price More Price(69)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | O6881 | Oxypurinol ≥98% (HPLC) | 2465-59-0 | 100mg | $251 | 2026-04-30 | Buy |
| Sigma-Aldrich | 42688 | Oxypurinol analytical standard | 2465-59-0 | 10mg | $99 | 2022-05-15 | Buy |
| Cayman Chemical | 18716 | Oxipurinol ≥95% | 2465-59-0 | 250mg | $41 | 2026-04-30 | Buy |
| Cayman Chemical | 18716 | Oxipurinol ≥95% | 2465-59-0 | 500mg | $75 | 2026-04-30 | Buy |
| Cayman Chemical | 18716 | Oxipurinol ≥95% | 2465-59-0 | 1g | $127 | 2026-04-30 | Buy |
Oxipurinol Chemical Properties, Uses, Production
Chemical Properties
Off White Solid
Uses
A metabolite of Allopurinol.
Uses
4,6-Dihydroxy-1H-pyrazolo[3,4-d]pyrimidine is an inhibitor to study the specificity and kinetics of xanthine oxidase. It is also used as an anti-inflammatory agent via inhibition of xanthine oxidase.
Uses
Oxypurinol, an allopurinol metabolite, is used as an inhibitor to study the specificity and kinetics of of xanthine oxidase(s). Oxypurinol is also used as an anti-inflammatory agent via inhibition of xanthine oxidase.
Definition
ChEBI: A pyrazolopyrimidine that is 4,5,6,7-tetrahydro-H-pyrazolo[3,4-d]pyrimidine substituted by oxo groups at positions 4 and 6.
Biological Activity
oxipurinol is a xanthine oxidoreductase inhibitor.xanthine oxidoreductase (xo), a complex molybdoflavoenzyme present in milk and many other tissues, has been studied for many years. xo is generally recognized as a critical enzyme in purine catabolism.
Biochem/physiol Actions
An allopurinol metabolite.
in vitro
allopurinol could be rapidly oxidized by xo to its active metabolite oxypurinol (both isosteres of hypoxanthine and xanthine, respectively), which also could inhibit xo. oxypurinol was identified as a noncompetitive inhibitor of xo; the formation of this compound was reported to be responsible for much of the pharmacological activity of allopurinol. moreover, both allopurinol and oxypurinol showed free radical scavenging effects in isolated hearts, and exerted cardioprotective effects despite no detectable xo activities [1].
in vivo
animal study found that in the vasculature of hypercholesterolemic rabbits, oxypurinol treatment led to a decrease in vascular free radical production [1].
References
[1] p. pacher, a. nivorozhkin and c. szabó. therapeutic effects of xanthine oxidase inhibitors: renaissance half a century after the discovery of allopurinol. pharmacological reviews 58(1), 87-114 (2006).
[2] day ro, graham gg, hicks m, mclachlan aj, stocker sl, williams km. clinical pharmacokinetics and pharmacodynamics of allopurinol and oxypurinol. clin pharmacokinet. 2007;46(8):623-44.
Oxipurinol Preparation Products And Raw materials
Raw materials
1of3
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai He-H Chemical Technology Co., Ltd | 18621911604 | 987025641@qq.com | China | 1233 | 58 |
| Shanghai Hongle Biotechnology Co., Ltd | 021-56145923; 4001631568 | sales@honglebiotech.com | China | 1036 | 58 |
| Hefei Shenghang Pharmaceutical Technology Co., Ltd. | 19156016681 18326946292 | 2816071490@QQ.COM | China | 362 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Shanghai AmasPharm Co., Ltd. | 021-54540637 18621091017 | sales@amaspharm.com | China | 787 | 62 |
View Latest Price from Oxipurinol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-04 | Oxipurinol
2465-59-0
|
1KG | 98% | 1ton | Henan Aochuang Chemical Co.,Ltd. |
-
- Oxipurinol
2465-59-0
- 98%
- Henan Aochuang Chemical Co.,Ltd.
