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1,3-Cyclohexanedione

1,3-Cyclohexanedione Structure
1,3-Cyclohexanedione structure
CAS No.
504-02-9
Chemical Name:
1,3-Cyclohexanedione
Synonyms
CYCLOHEXANE-1,3-DIONE;CHD;DIHYDRORESORCINOL;1,3-Cyclohexandione;TECO-013;NSC 57477;ohexanedione;Dihydroresorcin;Hydroresorcinol;1,3-CYCLOHEXANONE
CBNumber:
CB8319650
Molecular Formula:
C6H8O2
Molecular Weight:
112.13
MDL Number:
MFCD00001585
MOL File:
504-02-9.mol
MSDS File:
SDS
Last updated:2026-01-13 11:26:29
Product description Number Pack Size Price
1,3-Cyclohexanedione 97% C101605 5g $66.8
1,3-Cyclohexanedione 97% C101605 100g $104
1,3-Cyclohexanedione [for HPLC Labeling] >98.0%(GC)(T) A5581 5g $50
1,3-Cyclohexanedione >98.0%(GC)(T) C0682 25g $27
1,3-Cyclohexanedione 97% C101605 500g $264
More product size
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1,3-Cyclohexanedione Properties

Melting point 101-105 °C (lit.)
Boiling point 170.05°C (rough estimate)
Density 1,1 g/cm3
vapor pressure 0.018Pa at 25℃
refractive index 1.4576 (estimate)
storage temp. Store at +2°C to +8°C.
solubility Chloroform (Slightly), Methanol (Slightly)
pka 5.26(at 25℃)
form Powder
color Pale yellow to beige
Water Solubility soluble
Merck 14,3178
BRN 385888
InChI 1S/C6H8O2/c7-5-2-1-3-6(8)4-5/h1-4H2
InChIKey HJSLFCCWAKVHIW-UHFFFAOYSA-N
SMILES O=C1CCCC(=O)C1
LogP 0.461 at 21.4℃ and pH3.2
Surface tension 69.9mN/m at 1.01g/L and 22℃
CAS DataBase Reference 504-02-9(CAS DataBase Reference)
FDA UNII 6UK3D2BXJT
NIST Chemistry Reference 1,3-Cyclohexanedione(504-02-9)
EPA Substance Registry System 1,3-Cyclohexanedione (504-02-9)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS05,GHS07
Signal word  Danger
Hazard statements  H302-H318-H412
Precautionary statements  P273-P280-P301+P312+P330-P305+P351+P338+P310
PPE Eyeshields, Gloves, type N95 (US)
Safety Statements  24/25
WGK Germany  3
RTECS  GV0350000
F  8-21
TSCA  TSCA listed
HS Code  29142900
Storage Class 13 - Non Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
Aquatic Chronic 3
Eye Dam. 1
NFPA 704
1
2 0

1,3-Cyclohexanedione price More Price(45)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich C101605 1,3-Cyclohexanedione 97% 504-02-9 5g $66.8 2026-03-19 Buy
Sigma-Aldrich C101605 1,3-Cyclohexanedione 97% 504-02-9 100g $104 2026-03-19 Buy
TCI Chemical A5581 1,3-Cyclohexanedione [for HPLC Labeling] >98.0%(GC)(T) 504-02-9 5g $50 2026-03-19 Buy
TCI Chemical C0682 1,3-Cyclohexanedione >98.0%(GC)(T) 504-02-9 25g $27 2026-03-19 Buy
Sigma-Aldrich C101605 1,3-Cyclohexanedione 97% 504-02-9 500g $264 2026-03-19 Buy
Product number Packaging Price Buy
C101605 5g $66.8 Buy
C101605 100g $104 Buy
A5581 5g $50 Buy
C0682 25g $27 Buy
C101605 500g $264 Buy

1,3-Cyclohexanedione Chemical Properties,Uses,Production

Chemical Properties

pale yellow to beige powder

Uses

1,3-Cyclohexanedione is used in organic synthesis and pharmaceutical intermediates. It is the intermediate of herbicides sulcotrione and nitrosulfonone. It is also nitisinone intermediate.

Uses

1,3-Cyclohexanedione can be used as a building block in the synthesis of:

  • 9-substituted 1,8-dioxo-xanthenes by reacting with unactivated aldehydes via aldol condensation/ Michael addition reaction.
  • [(1,2,3-triazol-4-yl)methoxy-phenyl]-2H-indazolo[2,1-b]phthalazine-trione derivatives by treating with phthalhydrazide, aromatic propargyloxy aldehydes, and azides via a four-component condensation reaction.
It can be also used to prepare 2-substituted adducts, which are important intermediates for the synthesis of -enaminones , polyhydroquinoline derivatives , 1,8-dioxo-dodecahydroxanthenes , spirocyclopentanols , oxathioles , and triquinanes.

Definition

ChEBI: 1,3-Cyclohexanedione is a cyclohexanedione carrying oxo substituents at positions 1 and 3. It is a beta-diketone and a cyclohexanedione.

Synthesis Reference(s)

The Journal of Organic Chemistry, 30, p. 3206, 1965 DOI: 10.1021/jo01020a506

Synthesis

1,3-cyclohexanedione is made by combining resorcinol with sodium formate in water using 5% palladium on carbon in water at a pH of 5-11. After the completion of the reaction, the catalyst is separated by filtration. Next, a sufficient amount of concentrated HCl is added to lower the pH of the mixture to about 3, and the reaction is cooled and stirred for an additional 0.5-4.0 hours. Optionally, sodium chloride may be added to facilitate recovery of 1,3-cyclohexanedione.
1,3-Cyclohexanedione synthesis

Purification Methods

Crystallise the dione from *benzene. Dissolve ~50g of the diol in 140mL of *C6H6 under N2, cool, collect the solid and dry it in a vacuum desiccator overnight. It is unstable and should be stored under N2 or Ar at ~0o. [Thompson Org Synth Coll Vol III 278 1955, Beilstein 7 IV 1985.]

1,3-Cyclohexanedione synthesis

57910-97-1
504-02-9
Synthesis of 1,3-Cyclohexanedione from 2-Cyclohexen-1-one, 3-hydroxy-, sodium salt (1:1)

1,3-Cyclohexanedione Preparation Products And Raw materials

Raw materials

Resorcinol

Preparation Products

3-METHOXY-2-CYCLOHEXEN-1-ONE 5-(2-ETHYLTHIO PROPYL)-1,3-CYCLOHEXANEDIONE Ondansetron Sethoxydim 4-acetylbutyric acid
2-Oxo-(2H)-furo(2,3-h)-1-benzopyran 1,2,3,9-Tetrahydro-4(H)-carbazol-4-one 3-ETHOXY-2-CYCLOHEXEN-1-ONE 3-AMINO-2-CYCLOHEXEN-1-ONE 4-Aza-5a-androstan-1-ene-3-one-17b-carboxylic acid
6,7-Dihydro-4(5H)-benzofuranone 2-(2-OXO-2-PHENYL-ETHYL)-CYCLOHEXANE-1,3-DIONE 2-((3-OXOCYCLOHEX-1-ENYL)AMINO)BENZENECARBONITRILE 2H-3,7a-Methanobenzofuran-4(5H)-one, tetrahydro-

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1,3-Cyclohexanedione Suppliers

Global( 686)Suppliers
Supplier Tel Email Country ProdList Advantage
Zouping mingyuan import & export trading co., ltd
+86-0543-2240078 +8618364991597 myzhao793@163.com China 981 58
INNOBIO PHARM CO.,LTD
+8615600141006 cindyyb@126.com China 279 58
Hebei Chuanghai Biotechnology Co., Ltd 		+8615350571055 Sibel@chuanghaibio.com China 8738 58
Hebei Yanxi Chemical Co., Ltd. 		+8618531123677 faithe@yan-xi.com China 5853 58
Hebei Chuanghai Biotechnology Co,.LTD 		+86-86-13131129325 +8613131129325 sales1@chuanghaibio.com China 5235 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20124 58
Hebei Zhuanglai Chemical Trading Co.,Ltd 		+8613343047651 admin@zlchemi.com China 3692 58
Chongqing Soarwin Technology Co., Ltd 		+86-15790943001 crystal@sorawin.cn China 421 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29640 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-2158073036 info@dakenam.com China 13815 58
Supplier Advantage
Zouping mingyuan import & export trading co., ltd
58
INNOBIO PHARM CO.,LTD
58
Hebei Chuanghai Biotechnology Co., Ltd 		58
Hebei Yanxi Chemical Co., Ltd. 		58
Hebei Chuanghai Biotechnology Co,.LTD 		58
Henan Fengda Chemical Co., Ltd 		58
Hebei Zhuanglai Chemical Trading Co.,Ltd 		58
Chongqing Soarwin Technology Co., Ltd 		58
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58

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View Lastest Price from 1,3-Cyclohexanedione manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1,3-Cyclohexanedione pictures 2026-04-18 1,3-Cyclohexanedione
504-02-9
 0.99 RongNa Biotechnology Co.,Ltd
1,3-Cyclohexanedione pictures 2026-03-20 1,3-Cyclohexanedione
504-02-9
 US $1.00 / KG 1KG 99% 10 mt Hebei Chuanghai Biotechnology Co., Ltd
1,3-Cyclohexanedione pictures 2025-12-01 1,3-Cyclohexanedione
504-02-9
 US $0.00 / kg 1kg 99% 10000KGS Shaanxi Dideu New Materials Co. Ltd

1,3-Cyclohexanedione Spectrum

1,3-Cyclohexanedione(504-02-9)MS1,3-Cyclohexanedione(504-02-9)1HNMR1,3-Cyclohexanedione(504-02-9)13CNMR1,3-Cyclohexanedione(504-02-9)IR11,3-Cyclohexanedione(504-02-9)IR21,3-Cyclohexanedione(504-02-9)IR31,3-Cyclohexanedione(504-02-9)IR1,3-Cyclohexanedione(504-02-9)Raman

504-02-9(1,3-Cyclohexanedione)Related Search:

5,5-Dimethylhydroresorcinol(5,5-Dimethyl-1,3-Cyclohexanedione) Cyclohexane 2,5-Hexanedione 5-PHENYLCYCLOHEXANE-1,3-DIONE 1,3-Cyclohexanedione, 2-methyl-,2-Methyl-1,3-cyclohexanedione, 98+%
5-(4-CHLOROPHENYL)-1,3-CYCLOHEXANEDIONE 1,2-CYCLOHEXANEDIONE,1,2-Cyclohexanedione, 98+%,1,2-Cyclohexanedione,97% 4,4-Dimethyl-1,3-cyclohexanedione, GC 98% 5-ISOPROPYL-1,3-CYCLOHEXANEDIONE 2-ACETYL-1,3-CYCLOHEXANEDIONE
5-METHYLCYCLOHEXANE-1,3-DIONE 1,4-Dioxaspiro[4.5]decan-8-one 2-Ethyl-1,3-cyclopentanedione 1,2-CYCLOHEXANEDIONE DIOXIME 2-Methyl-1,3-cyclopentanedione
1,3-CYCLOHEXADIENE CYCLOHEXANEDIONE,1,4-Cyclohexanedione,98% 1,3-Cyclohexanedione99%

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Dihydro-1,3-benzenediol NSC 57477 1,3-Cyclohexanedione, 97% 500GR 1,3-Cyclohexanedione 97% 1,3-Cyclohexanedione SynonyMs Cyclohexane-1,3-dione 1,3-Cyclohexanedione, 97+%, may cont. up to 1% NaCl 1,3-Cyclohexanedione [for HPLC Labeling] 1,3-Diketocyclohexane Dihydroresorcin 1,3-Cyclohexanedione, May Cont. up to 1% Nacl Dihydroresorcinol, 1,3-Dioxocyclohexane 1,3-Cyclohexanedione, 97% 100GR Cyclohexan-1,3-dion ohexanedione Molindone Impurity B Nitisinone Impurity 1（1,3-Cyclohexanedione） 1,3-Benzenediol, dihydro- 1,3-Cyclohexandione Hydroresorcinol Resorcinol, dihydro- DIHYDRORESORCINOL 1,3-CYCHEXANEDIONE 1,3-cycloadipic ketone 1,3-CYCLOHEXANEDIONE, FOR FLUORESCENCE 1,3-Cyclohexanedione, 97+% 1,3-Cyclohexanedione,98% 1,3-CYCLOHEXANONE 1,3-Dioxocyclohexane 1,3-CYCLOHEXANEDIONE 1,3-Cyclohexanedione > [2-14C] cyclohexane-1,3-dione 1,3-Cyclohexanedione, 97%, for synthesis 1,3-Cyclohexanedione [for HPLC Labeling]> 1,3-CYCLOHEXANEDIONE FOR SYNTHESIS 1,3-CYCLOHEXANEDIONE CHD Dimethyl octadecanoate TECO-013 1,3-Cyclohexanedione (7CI, 8CI, 9CI, ACI) Cyclohexan-1,3-dione (2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(hexadecyloxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite 1,3-cyclohexanedione, 99%min CYCLOHEXANE-1,3-DIONE CHD 504-02-9 765-87-8 C6H6OH2 Building Blocks Biochemicals and Reagents BioChemical HPLC Labeling Reagents Fluorescence Detection (HPLC Labeling Reagents) Carbonyl Group Labeling Reagents for Fluorescence HPLC Fluorescent Probes, Labels, Particles and Stains Detection Organic Building Blocks Ketones C3 to C6 Carbonyl Compounds